Role of nanoscale antigen organization on B-cell activation probed using DNA origami

Nature Nanotechnology, Год журнала: 2020, Номер 15(8), С. 716 - 723

Опубликована: Июнь 29, 2020

Язык: Английский

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Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Nature Medicine, Год журнала: 2021, Номер 27(12), С. 2085 - 2098

Опубликована: Дек. 1, 2021

Язык: Английский

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CD8+ T cells in HIV control, cure and prevention

Nature reviews. Immunology, Год журнала: 2020, Номер 20(8), С. 471 - 482

Опубликована: Фев. 12, 2020

Язык: Английский

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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

Nature reviews. Immunology, Год журнала: 2022, Номер 23(3), С. 142 - 158

Опубликована: Авг. 12, 2022

Язык: Английский

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Carbohydrate-Based Macromolecular Biomaterials

Chemical Reviews, Год журнала: 2021, Номер 121(18), С. 10950 - 11029

Опубликована: Авг. 2, 2021

Carbohydrates are the most abundant and one of important biomacromolecules in Nature. Except for energy-related compounds, carbohydrates can be roughly divided into two categories: as matter information. As matter, abundantly present extracellular matrix animals cell walls various plants, bacteria, fungi, etc., serving scaffolds. Some commonly found polysaccharides featured biocompatible materials with controllable rigidity functionality, forming polymeric biomaterials which widely used drug delivery, tissue engineering, etc. information, usually referred to glycans from glycoproteins, glycolipids, proteoglycans, bind proteins or other carbohydrates, thereby meditating cell–cell cell–matrix interactions. These could simplified synthetic glycopolymers, afforded through polymerization, multistep synthesis, a semisynthetic strategy. The information role demonstrated not only targeting reagents but also immune antigens adjuvants. latter included this review they always macromolecular formulation. In review, we intend provide relatively comprehensive summary carbohydrate-based since 2010 while emphasizing fundamental understanding guide rational design biomaterials. Carbohydrate-based macromolecules on basis their resources chemical structures will discussed, including naturally occurring polysaccharides, derived glycopolymers/glycodendrimers, supramolecular glycolipids/glycoproteins. Multiscale structure–function relationships several major application areas, delivery systems, immunology, detailed. We hope valuable development build bridge between promote new biomaterial near future.

Язык: Английский

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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Immunity, Год журнала: 2020, Номер 53(3), С. 548 - 563.e8

Опубликована: Авг. 27, 2020

Язык: Английский

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Vaccination induces HIV broadly neutralizing antibody precursors in humans

Science, Год журнала: 2022, Номер 378(6623)

Опубликована: Дек. 1, 2022

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the vaccine-priming candidate eOD-GT8 60mer adjuvanted with AS01

Язык: Английский

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Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants

Nature, Год журнала: 2021, Номер 600(7889), С. 530 - 535

Опубликована: Окт. 20, 2021

Abstract The emergence of SARS-CoV-2 variants is jeopardizing the effectiveness current vaccines and limiting application monoclonal antibody-based therapy for COVID-19 (refs. 1,2 ). Here we analysed memory B cells five naive convalescent people vaccinated with BNT162b2 mRNA vaccine to investigate nature cell antibody response at single-cell level. Almost 6,000 were sorted, over 3,000 produced antibodies against spike protein more than 400 neutralized original virus first identified in Wuhan, China. B.1.351 (Beta) B.1.1.248 (Gamma) escaped almost 70% these antibodies, while a much smaller portion was impacted by B.1.1.7 (Alpha) B.1.617.2 (Delta) variants. overall loss neutralization always significantly higher from people. In part, this due IGHV2-5;IGHJ4-1 germline, which found only who generated potent broadly neutralizing antibodies. Our data suggest that are seropositive following infection or primary vaccination will produce increased potency breadth be able better control emerging

Язык: Английский

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A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Nature Medicine, Год журнала: 2021, Номер 27(12), С. 2234 - 2245

Опубликована: Дек. 1, 2021

Язык: Английский

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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

Immunity, Год журнала: 2023, Номер 56(3), С. 669 - 686.e7

Опубликована: Фев. 16, 2023

Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coronaviruses and more effectively respond SARS-CoV-2 variants. The emergence of Omicron subvariants illustrates limitations solely targeting receptor-binding domain (RBD) spike (S) protein. Here, we isolated a large panel (bnAbs) from recovered-vaccinated donors, which targets conserved S2 region in betacoronavirus fusion machinery. Select bnAbs showed broad vivo protection all three deadly betacoronaviruses, SARS-CoV-1, SARS-CoV-2, MERS-CoV, have spilled over into humans past two decades. Structural studies these delineated molecular basis for their reactivity revealed common antibody features targetable by vaccination strategies. These provide new insights opportunities antibody-based interventions pan-betacoronavirus vaccines.

Язык: Английский

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