Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 111018 - 111018
Опубликована: Сен. 21, 2023
Язык: Английский
Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 111018 - 111018
Опубликована: Сен. 21, 2023
Язык: Английский
Chemical Society Reviews, Год журнала: 2023, Номер 52(9), С. 2992 - 3034
Опубликована: Янв. 1, 2023
The flourishing development of flexible healthcare sensing systems is inseparable from the fundamental materials with application-oriented mechanical and electrical properties. Thanks to continuous inspiration our Mother Nature, hydrogels originating natural biomass are attracting growing attention for their structural functional designs owing unique chemical, physical biological These highly efficient architectural enable them be most promising candidates electronic devices. This comprehensive review focuses on recent advances in naturally sourced constructing multi-functional sensors applications thereof. We first briefly introduce representative polymers, including polysaccharides, proteins, polypeptides, summarize physicochemical design principles fabrication strategies hydrogel based these polymers outlined after material properties required presented. then highlight various techniques devices, illustrate examples wearable or implantable bioelectronics pressure, strain, temperature, biomarker field systems. Finally, concluding remarks challenges prospects hydrogel-based provided. hope that this will provide valuable information next-generation build a bridge between as matter an applied target accelerate new near future.
Язык: Английский
Процитировано
201Exploration, Год журнала: 2022, Номер 2(6)
Опубликована: Май 23, 2022
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.
Язык: Английский
Процитировано
200Advanced Materials, Год журнала: 2022, Номер 35(4)
Опубликована: Май 31, 2022
Nanochitin and nanochitosan (with random-copolymer-based multiscale architectures of glucosamine N-acetylglucosamine units) have recently attracted immense attention for the development green, sustainable, advanced functional materials. are materials from small oligomers, rod-shaped nanocrystals, longer nanofibers, to hierarchical assemblies nanofibers. Various physical properties chitin chitosan depend on their molecular- nanostructures; translational research has utilized them a wide range applications (biomedical, industrial, environmental, so on). Instead reviewing entire extensive literature chitosan, here, recent developments in multiscale-dependent material highlighted; immune, medical, reinforcing, adhesive, green electrochemical materials, biological scaffolds, sustainable food packaging discussed considering size, shape, assembly nanostructures. In summary, new perspectives based nanochitin by understanding engineering described.
Язык: Английский
Процитировано
135Composites Part B Engineering, Год журнала: 2022, Номер 247, С. 110313 - 110313
Опубликована: Окт. 4, 2022
Язык: Английский
Процитировано
95Journal of Advanced Research, Год журнала: 2022, Номер 43, С. 87 - 96
Опубликована: Фев. 24, 2022
High-dose drug administration for the conventional treatment of inflammatory bowel disease induces cumulative toxicity and serious side effects. Currently, few reports have introduced smart carriers intestinal inflammation targeting toward disease. For unique lysozyme secretory microenvironment inflamed intestine, vancomycin-loaded chitosan-polyaniline microgels (CH-PANI MGs) were constructed lysozyme-triggered VM release. Aniline was first grafted to chitosan form polymers that crosslinked by glutaraldehyde achieve CH-PANI MGs using inverse (water-in-oil) miniemulsion method. Interestingly, exhibit polyampholyte behaviour display charge-reversible (positive negative charges) after with a NaCl solution. The formed negatively charged N-CH-PANI MG aqueous solution is employed load cationic vancomycin satisfactory loading efficiency 91.3%, which significantly higher than chitosan-based MGs. Moreover, present biodegradation controllable release upon cleavage glycosidic linkages chitosan. In simulated microenvironment, rapidly released, reaches approximately 76.9%. Remarkably, N-CH-PANI@VM not only high resistance harsh gastric acidity but also prevent premature leakage in healthy gastrointestinal tract. Encouragingly, show obvious antibacterial activity against Staphylococcus aureus at relatively low concentration 20 μg/mL. Compared other pH-responsive used treat disease, key advantage lysozyme-responsive they further specifically identify intestines, achieving efficient With this excellent performance, developed might be as potential oral delivery system treatment.
Язык: Английский
Процитировано
89Theranostics, Год журнала: 2022, Номер 12(3), С. 1419 - 1439
Опубликована: Янв. 1, 2022
The past few years has witnessed a booming market of protein and peptide drugs, owing to their superior efficiency biocompatibility.Parenteral route is the most commonly employed method for drugs administration.However, short plasma half-life requires repetitive injections results in poor patient compliance.Oral delivery promising alternative but hindered by harsh gastrointestinal environment defensive intestinal epithelial barriers.Therefore, designing suitable oral systems been persistent challenge.This review summarizes main challenges highlights advanced formulation strategies improve bioavailability.More importantly, major cell types available targeting receptors are introduced along with potential target these types.We also described multifunctional biomaterials which can be used prepare carrier as well modulate mucosal immune response.Understanding emerging will surely inspire production that serves therapeutic needs clinical settings.
Язык: Английский
Процитировано
87Pharmaceutics, Год журнала: 2022, Номер 14(1), С. 145 - 145
Опубликована: Янв. 7, 2022
3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well in the large choice of materials. It is a powerful tool field personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant inexpensive natural polymers, that already widely used food industry excipients cosmetic formulations. Due their intrinsic properties, such biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides largely investigated matrices drug delivery. Although an increasing number interesting reviews on manufacturing delivery being published, there gap concerning printing polysaccharides. In this article, we will review recent advances focused applications. Among family polysaccharides, present focus cellulose derivatives, chitosan sodium alginate, printed by fused deposition modeling extrusion-based printing.
Язык: Английский
Процитировано
76Advanced Science, Год журнала: 2023, Номер 10(20)
Опубликована: Май 3, 2023
Abstract Malignant ascites in advanced hepatocellular carcinoma (HCC) is a complex clinical problem that lacks effective treatments. Due to the insensitivity of HCC cells traditional chemotherapies, low drug accumulation, and limited residence time peritoneal cavity, therapeutic effects malignant are not satisfactory. In this study, an injectable hydrogel delivery system based on chitosan hydrochloride oxidized dextran (CH‐OD) designed load sulfasalazine (SSZ), FDA‐approved with ferroptosis‐inducing ability, for tumor‐killing activation anti‐tumor immunity. Compared free SSZ, SSZ‐loaded CH‐OD (CH‐OD‐SSZ) exhibits greater cytotoxicity induces higher levels immunogenic ferroptosis. preclinical model hepatoma ascites, intraperitoneal administration CH‐OD‐SSZ can significantly suppress tumor progression improve immune landscape. Both vitro vivo, repolarization macrophages M1‐like phenotype promotes maturation dendritic cells. Combination treatment anti‐programmed cell death protein 1 (PD‐1) immunotherapy achieves more than 50% regression generates long‐term memory. Collectively, promising potential dissemination HCC, especially when combined anti‐PD‐1 immunotherapy.
Язык: Английский
Процитировано
57Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 4086 - 4153
Опубликована: Янв. 1, 2024
This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.
Язык: Английский
Процитировано
51Chemical Reviews, Год журнала: 2023, Номер 123(10), С. 6793 - 6838
Опубликована: Апрель 26, 2023
Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It is thus essential to develop methods for synthesizing, functionalizing, and manipulating carbohydrates further understanding of their functions creation sugar-based functional materials. is, however, not trivial such methods, since densely decorated with polar similarly reactive hydroxy groups stereodefined manner. New approaches chemo- site-selective transformations are, therefore, great significance revolutionizing sugar chemistry enable easier access sugars interest. This review begins brief overview innate reactivity carbohydrates. followed by discussions about catalytic enhance, override, or be orthogonal transformation avoids making list reactions, but rather focuses on summarizing concept behind each reported transformation. The literature references were sorted into sections based underlying ideas approaches, which we hope will help readers have better sense current state innovative field.
Язык: Английский
Процитировано
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