Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Nature Neuroscience, Год журнала: 2022, Номер 25(8), С. 1059 - 1070

Опубликована: Июль 7, 2022

Язык: Английский

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The glymphatic system: Current understanding and modeling

iScience, Год журнала: 2022, Номер 25(9), С. 104987 - 104987

Опубликована: Авг. 20, 2022

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid interstitial around brain, facilitating solute transport. Models enable hypothesis development predictions transport, with clinical applications including drug delivery, stroke, cardiac arrest, neurodegenerative disorders like Alzheimer's disease. sort existing into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, links neuronal activity. Needs opportunities for future work are highlighted wherever possible; new models, expanded novel experiments inform could all have tremendous value advancing field.

Язык: Английский

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Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

JAMA Neurology, Год журнала: 2021, Номер 78(10), С. 1187 - 1187

Опубликована: Авг. 30, 2021

Importance

Disrupted sleep is common in aging and associated with cognition. Age-related changes to are multiple causes, including early Alzheimer disease pathology (amyloid β [Aβ]), depression, cardiovascular disease.

Objective

To investigate the associations between self-reported duration brain Aβ burden as well demographic, cognitive, lifestyle variables adults normal

Design, Setting, Participants

This cross-sectional study obtained data from participants Anti-Amyloid Treatment Asymptomatic Alzheimer's Disease (A4) study, which being conducted 67 sites United States, Canada, Australia, Japan. The sample for this analysis consisted of individuals aged 65 85 years who underwent an positron emission tomography (PET) scan, had complete apolipoprotein E (APOE) genotype data, were identified clinically (per a Clinical Dementia Rating score 0) cognitively unimpaired Mini-Mental State Examination 25 30 Logical Memory Delayed Recall test 6 18). Data analyzed April 3, 2020, June 20, 2021.

Main Outcomes Measures

outcome was nightly (grouped by short duration: ≤6 hours, 7-8 long ≥9 hours) compared demographic characteristics, (as measured fluorine 18–labeled-florbetapir PET scan), objective subjective cognitive function measures, variables.

Results

4417 included 2618 women (59%) mean (SD) age 71.3 (4.7) years. Self-reported shorter linearly higher (β [SE] = –0.01 [0.00];P .005), reduced cognition that mostly memory domains. No difference found groups 0.00 [0.01];P .99). However, duration, both durations body mass index (short vs 0.48 [0.17],P .01; 0.97 [0.31],P .002), depressive symptoms 0.31 [0.05],P < .001; 0.39 [0.09],P .001), daytime napping 2.66 [0.77],P 3.62 [1.38],P .01). Long worse performance across

Conclusions Relevance

In outcomes older adults, such greater burden, symptoms, index, decline, emphasizing importance maintaining adequate sleep.

Язык: Английский

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Emergence and Developmental Roles of the Cerebrospinal Fluid System

Developmental Cell, Год журнала: 2020, Номер 52(3), С. 261 - 275

Опубликована: Фев. 1, 2020

We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function. More than a protective cushion and sink for waste, the CSF is an integral CNS component with dynamic diverse roles emerging in parallel developing CNS. This review examines current understanding about early its maturation during development discusses open questions field. focus on developmental changes ventricular system sources (including neural progenitors choroid plexus). also discuss concepts related to of dynamics including flow, perivascular transport, drainage, barriers.

Язык: Английский

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A mesothelium divides the subarachnoid space into functional compartments

Science, Год журнала: 2023, Номер 379(6627), С. 84 - 88

Опубликована: Янв. 5, 2023

The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes subarachnoid space in mouse human brain, designated lymphatic-like membrane (SLYM). SLYM morpho- immunophenotypically similar to mesothelial lining peripheral organs body cavities, it encases blood vessels harbors immune cells. Functionally, close apposition with endothelial venous sinus permits direct exchange small solutes between cerebrospinal fluid blood, thus representing equivalent arachnoid granulations. functional characterization provides fundamental insights into brain barriers transport.

Язык: Английский

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Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years

Current Biology, Год журнала: 2020, Номер 30(21), С. 4291 - 4298.e3

Опубликована: Сен. 3, 2020

Язык: Английский

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Resting-state “physiological networks”

NeuroImage, Год журнала: 2020, Номер 213, С. 116707 - 116707

Опубликована: Март 9, 2020

Slow changes in systemic brain physiology can elicit large fluctuations fMRI time series, which manifest as structured spatial patterns of temporal correlations between distant regions. Here, we investigated whether such "physiological networks"—sets segregated regions that exhibit similar responses following slow physiology—resemble associated with large-scale networks typically attributed to remotely synchronized neuronal activity. By analyzing a group subjects from the 3T Human Connectome Project (HCP) database, demonstrate brain-wide and noticeably heterogenous dynamics tightly coupled either respiratory variation or heart rate changes. We show, using synthesized data generated physiological recordings across subjects, these physiologically-coupled alone produce strongly resemble previously reported resting-state networks, suggesting that, some cases, networks" seem mimic networks. Further, show physiologically-relevant connectivity estimates appear dominate overall observations multiple HCP this apparent connectivity" cannot be removed by use single nuisance regressor for entire (such global signal regression) due clear regional heterogeneity responses. Our results challenge previous notions confounds are localized veins globally coherent cortex, therefore emphasizing necessity consider potential contributions fMRI-based functional studies. The rich spatiotemporal carried "physiological" also suggest great clinical biomarkers complementary

Язык: Английский

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Noradrenergic circuit control of non-REM sleep substates

Current Biology, Год журнала: 2021, Номер 31(22), С. 5009 - 5023.e7

Опубликована: Окт. 14, 2021

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred around mean levels greater than ones quiet wakefulness, while (NA) declined steeply REMS. They coincided clustering spindle rhythms forebrain heart-rate variations, both which are correlates arousability. We addressed origins these by using closed-loop optogenetic locus coeruleus (LC) activation or inhibition timed moments low high NREMS. suppress, lock, entrain sleep-spindle fore- hindbrain-projecting LC neurons show coordinated infraslow variations natural Noradrenergic modulation thalamic, but not cortical, circuits was required for involved NA release into primary reticular thalamic nuclei activated α1- β-adrenergic receptors cause slowly decaying membrane depolarizations. signaling constitutes vigilance-promoting mechanism renders mammalian disruption close-to-minute through sustaining thalamocortical autonomic arousability.Video abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading ...(mp4, 35.34 MB) Download video

Язык: Английский

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Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management

Current Opinion in Neurology, Год журнала: 2021, Номер 34(2), С. 246 - 257

Опубликована: Фев. 23, 2021

Purpose of review We present recent developments in the field small vessel disease (SVD)-related vascular cognitive impairment, including pathological mechanisms, updated diagnostic criteria, profile, neuroimaging markers and risk factors. further address available management therapeutic strategies. Recent findings Vascular neurodegenerative pathologies often co-occur share similar The consensus criteria aim to standardize impairment (VCI) diagnosis, relying strongly on profile MRI findings. Aggressive blood pressure control multidomain lifestyle interventions are associated with decreased but disease-modifying treatments still lacking. research has led a better understanding mechanisms leading SVD-related decline, such as blood-brain barrier dysfunction, reduced cerebrovascular reactivity impaired perivascular clearance. Summary SVD is cause VCI substantial morbidity. Tackling cardiovascular factors currently most effective approach prevent decline elderly. Advanced imaging techniques provide tools for early diagnosis may play an important role surrogate endpoints clinical trials. Designing testing remains key priority healthcare.

Язык: Английский

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Advances in resting state fMRI acquisitions for functional connectomics

NeuroImage, Год журнала: 2021, Номер 243, С. 118503 - 118503

Опубликована: Авг. 31, 2021

Resting state functional magnetic resonance imaging (rs-fMRI) is based on spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal, which occur simultaneously different brain regions, without subject performing an explicit task. The low-frequency oscillations of rs-fMRI signal demonstrate intrinsic spatiotemporal organization (brain networks) that may relate to underlying neural activity. In this review article, we briefly describe current acquisition techniques for data, from most common approaches resting strategies, more recent investigations with dedicated hardware and ultra-high fields. Specific sequences allow very fast acquisitions, or multiple echoes, are discussed next. We then consider how methods weighted towards specific parts BOLD like Cerebral Blood Flow (CBF) Volume (CBV), can provide spatially network information. These being developed alongside commonly used BOLD-weighted acquisitions. Finally, applications challenging regions such as laminae neocortex, networks within large areas subcortical white matter discussed. finish recommendations strategies a range typical fMRI.

Язык: Английский

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