bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 26, 2024
We
here
revisited
the
concept
that
glymphatic
clearance
is
enhanced
by
sleep
and
anesthesia.
Utilizing
dynamic
magnetic
resonance
imaging
(MRI),
single
photon
emission
computed
tomography
(SPECT),
fluorescent
fiber
photometry,
we
report
brain
both
anesthesia,
sharply
suppressed
wakefulness.
Another
key
finding
was
less
tracer
enters
brains
of
awake
animals
across
different
states
can
only
be
compared
after
adjusting
for
injected
dose.
Contemporary
studies
have
completely
changed
the
view
of
brain
immunity
from
envisioning
as
isolated
and
inaccessible
to
peripheral
immune
cells
an
organ
in
close
physical
functional
communication
with
system
for
its
maintenance,
function,
repair.
Circulating
reside
special
niches
brain's
borders,
choroid
plexus,
meninges,
perivascular
spaces,
which
they
patrol
sense
a
remote
manner.
These
niches,
together
meningeal
lymphatic
skull
microchannels,
provide
multiple
routes
interaction
between
system,
addition
blood
vasculature.
In
this
Review,
we
describe
current
ideas
about
their
implications
aging,
diseases,
immune-based
therapeutic
approaches.
Neuron,
Год журнала:
2023,
Номер
111(23), С. 3745 - 3764.e7
Опубликована: Сен. 29, 2023
Leptomeninges,
consisting
of
the
pia
mater
and
arachnoid,
form
a
connective
tissue
investment
barrier
enclosure
brain.
The
exact
nature
leptomeningeal
cells
has
long
been
debated.
In
this
study,
we
identify
five
molecularly
distinct
fibroblast-like
transcriptomes
in
cerebral
leptomeninges;
link
them
to
anatomically
cell
types
pia,
inner
outer
arachnoid
barrier,
dural
border
layer;
contrast
sixth
transcriptome
present
choroid
plexus
median
eminence.
Newly
identified
transcriptional
markers
enabled
molecular
characterization
responsible
for
adherence
layers
one
another
barrier.
These
also
proved
useful
identifying
features
development,
injury,
repair
that
were
preserved
or
changed
after
traumatic
brain
injury.
Together,
findings
highlight
value
fibroblast
subsets
their
cellular
locations
toward
advancing
understanding
physiology
pathology.
EBioMedicine,
Год журнала:
2024,
Номер
100, С. 104963 - 104963
Опубликована: Янв. 5, 2024
Glioblastoma
(GBM)
is
one
of
the
most
lethal
central
nervous
systems
(CNS)
tumours
in
adults.
As
supplements
to
standard
care
(SOC),
various
immunotherapies
improve
therapeutic
effect
other
cancers.
Among
them,
tumour
vaccines
can
serve
as
complementary
monotherapy
or
boost
clinical
efficacy
with
immunotherapies,
such
immune
checkpoint
blockade
(ICB)
and
chimeric
antigen
receptor
T
cells
(CAR-T)
therapy.
Previous
studies
GBM
have
suggested
that
few
neoantigens
could
be
targeted
due
low
mutation
burden,
single-peptide
vaccination
had
limited
control
monotherapy.
Combining
diverse
antigens,
including
neoantigens,
tumour-associated
antigens
(TAAs),
pathogen-derived
optimizing
vaccine
design
strategy
may
help
improvement.
In
this
review,
we
discussed
current
platforms,
evaluated
potential
antigenic
targets,
challenges,
perspective
opportunities
for
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 5, 2024
Abstract
The
human
subarachnoid
space
harbors
the
cerebrospinal
fluid,
which
flows
within
a
landscape
of
blood
vessels
and
trabeculae.
Functional
implications
anatomy
remain
far
less
understood.
This
study
75
patients
utilizes
fluid
tracer
(gadobutrol)
consecutive
magnetic
resonance
imaging
to
investigate
features
early
(i.e.
2-3
h
after
injection)
propagation
space.
There
is
time-dependent
perivascular
pattern
enrichment
antegrade
along
major
cerebral
artery
trunks;
anterior-,
middle-,
posterior
arteries.
correlation
between
time
first
around
arteries
in
nearby
cortex
significant.
These
observations
suggest
existence
compartmentalized
space,
where
ensheathment
facilitates
passage
towards
brain
tissue.
Periarterial
transport
impaired
subjects
with
reduced
intracranial
pressure-volume
reserve
capacity
idiopathic
normal
pressure
hydrocephalus
who
also
show
increased
size.
Science,
Год журнала:
2024,
Номер
385(6704), С. 80 - 86
Опубликована: Июль 4, 2024
Classical
migraine
patients
experience
aura,
which
is
transient
neurological
deficits
associated
with
cortical
spreading
depression
(CSD),
preceding
headache
attacks.
It
not
currently
understood
how
a
pathological
event
in
cortex
can
affect
peripheral
sensory
neurons.
In
this
study,
we
show
that
cerebrospinal
fluid
(CSF)
flows
into
the
trigeminal
ganglion,
establishing
nonsynaptic
signaling
between
brain
and
cells.
After
CSD,
~11%
of
CSF
proteome
altered,
up-regulation
proteins
directly
activate
receptors
ganglion.
collected
from
animals
exposed
to
CSD
activates
neurons
naïve
mice
part
by
CSF-borne
calcitonin
gene-related
peptide
(CGRP).
We
identify
communication
pathway
central
nervous
system
might
explain
relationship
migrainous
aura
headache.
