Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Environmental Science & Technology Letters, Год журнала: 2021, Номер 8(10), С. 839 - 852

Опубликована: Сен. 7, 2021

The concept of the exposome was introduced over 15 years ago to reflect important role that environment exerts on health and disease. While originally viewed as a call-to-arms develop more comprehensive exposure assessment methods applicable at individual level throughout life course, scope has now expanded include associated biological response. In order explore these concepts, workshop hosted by Gunma University Initiative for Advanced Research (GIAR, Japan) discuss exposomics from an international multidisciplinary perspective. This Global Perspective is summary discussions with emphasis (1) top-down, bottom-up, functional approaches exposomics, (2) need integration standardization LC- GC-based high-resolution mass spectrometry untargeted analyses, (3) design study, (4) requirement open science workflows including spectral libraries public databases, (5) necessity large investments in infrastructure sequence exposome, (6) precision medicine nutrition create personalized environmental profiles. Recommendations are made key issues encourage continued advancement cooperation exposomics.

Язык: Английский

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Identification and Prioritization of Environmental Organic Pollutants: From an Analytical and Toxicological Perspective

Chemical Reviews, Год журнала: 2023, Номер 123(17), С. 10584 - 10640

Опубликована: Авг. 2, 2023

Exposure to environmental organic pollutants has triggered significant ecological impacts and adverse health outcomes, which have been received substantial increasing attention. The contribution of unidentified chemical components is considered as the most knowledge gap in understanding combined effects pollutant mixtures. To address this issue, remarkable analytical breakthroughs recently made. In review, basic principles on recognition are overviewed. Complementary methodologies (i.e., quantitative structure–activity relationship prediction, mass spectrometric nontarget screening, effect-directed analysis) experimental platforms briefly described. stages technique development and/or essential parts workflow for each then reviewed. Finally, plausible paths applications future screening methods, interdisciplinary techniques achieving toxicant identification, burgeoning strategies risk assessment cocktails discussed.

Язык: Английский

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One planet: one health. A call to support the initiative on a global science–policy body on chemicals and waste

Environmental Sciences Europe, Год журнала: 2022, Номер 34(1)

Опубликована: Март 8, 2022

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support initiative based on awareness that humanity already likely left safe operating space within planetary boundaries for novel entities including pollution. Immediate action is essential needs to be informed by sound scientific knowledge data compiled critically evaluated interface body. Major challenges such a are (i) foster global production exposure, impacts governance going beyond data-rich regions (e.g., Europe North America), (ii) cover entirety hazardous chemicals, mixtures wastes, (iii) follow one-health perspective considering risks posed chemicals waste ecosystem health, (iv) strive solution-oriented assessments systems thinking. Based multiple evidence urgent scale, we call scientists practitioners mobilize their networks intensify interaction with national governments negotiations intergovernmental explaining anticipated benefit health.

Язык: Английский

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A Children’s Health Perspective on Nano- and Microplastics

Environmental Health Perspectives, Год журнала: 2022, Номер 130(1)

Опубликована: Янв. 1, 2022

Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- microplastics (NMPs) remain largely uninvestigated or unknown. Although plastic chemicals a well-established research topic, impacts particles unexplored, especially with regard early life exposures.This commentary aims summarize knowns unknowns around child- pregnancy-relevant exposures NMPs via inhalation, placental transfer, ingestion breastmilk, dermal absorption.A comprehensive literature search map state science on found 37 primary articles relevance during revealed major knowledge gaps in field. We discuss opportunities challenges quantifying child-specific (e.g., breastmilk infant formula) effects, light global inequalities baby bottle use, consumption packaged foods, air pollution, hazardous disposal, regulatory safeguards. also needs linking child NMP address context public action.Few studies have addressed sources exposure, estimates currently rely generic assumptions rather than empirical measurements. Furthermore, toxicological has not specifically focused health, yet children's immature defense mechanisms make them particularly vulnerable. Apart from few investigating transfer NMPs, physicochemical properties polymer, size, shape, charge) driving absorption, biodistribution, elimination be benchmarked. Accordingly, evidence base regarding potential remains sparse. Based date, we provide recommendations fill gaps, stimulate policymakers industry safety point families reduce plastic. https://doi.org/10.1289/EHP9086.

Язык: Английский

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A Floating Integrated Solar Micro‐Evaporator for Self‐Cleaning Desalination and Organic Degradation

Advanced Functional Materials, Год журнала: 2023, Номер 33(28)

Опубликована: Апрель 9, 2023

Abstract Safe and clean freshwater harvesting from (organic‐containing) saline or wastewater holds great potential for mitigating water scarcity pollution, but remains challenging. Herein, a floating photothermal/catalytic‐integrated interfacial micro‐evaporator ( g ‐C 3 N 4 @PANI/PS) is reported as proof‐of‐concept multifunctional scavenger evaporator system (MSES) to achieve both solar‐driven complete desalination organic degradation. The spherical porous lightweight polystyrene core, incorporated with black surface functional layer @PANI), enables the hybrid naturally float thereby collectively self‐assemble under tension evaporation, which achieves preeminent self‐cleaning salt/solute separation efficient photodegradation rotation. Remarkably, high solar‐vapor conversion efficiency of ≈90% energy localization provides abundant active photocatalytic sites on interface, further enhanced by photothermal cooperation. High photo‐driven degradation efficiencies 99% nonvolatile compounds (non‐VOC) bisphenol A 95% VOC phenol in are achieved. An outdoor comprehensive solar treatment test toward organic‐containing high‐salinity sewage verifies feasibility MSES sustainable (1.3 kg m −2 h −1 ), downstream salt recovery, This strategy may inspire an integrated solution scarcity, energy, environmental pollution carbon neutrality.

Язык: Английский

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Comprehensive review of emerging contaminants: Detection technologies, environmental impact, and management strategies

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 278, С. 116420 - 116420

Опубликована: Май 2, 2024

Emerging contaminants (ECs) are a diverse group of unregulated pollutants increasingly present in the environment. These contaminants, including pharmaceuticals, personal care products, endocrine disruptors, and industrial chemicals, can enter environment through various pathways persist, accumulating food chain posing risks to ecosystems human health. This comprehensive review examines chemical characteristics, sources, varieties ECs. It critically evaluates current understanding their environmental health impacts, highlighting recent advancements challenges detection analysis. The also assesses existing regulations policies, identifying shortcomings proposing potential enhancements. ECs pose significant wildlife by disrupting animal hormones, causing genetic alterations that diminish diversity resilience, altering soil nutrient dynamics physical Furthermore, increasing health, hormonal disruptions, antibiotic resistance, disruption, neurological effects, carcinogenic other long-term impacts. To address these critical issues, offers recommendations for future research, emphasizing areas requiring further investigation comprehend full implications contaminants. suggests increased funding support development advanced technologies, establishment standardized methods, adoption precautionary regulations, enhanced public awareness education, cross-sectoral collaboration, integration scientific research into policy-making. By implementing solutions, we improve our ability detect, monitor, manage ECs, reducing risks.

Язык: Английский

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Achieving health-oriented air pollution control requires integrating unequal toxicities of industrial particles

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Окт. 14, 2023

Protecting human health from fine particulate matter (PM) pollution is the ambitious goal of clean air actions, but current control strategies largely ignore role source-specific PM toxicity. Here, we proposed health-oriented by integrating unequal toxic potencies most polluting industrial PMs. Iron and steel industry (ISI)-emitted PM2.5 exhibit about one order magnitude higher potency than those cement power industries. Compared with mass-based strategy (prioritizing implementation ultralow emission standards in sector), (priority ISI sector) could generate 5.4 times reduction population-weighted potency-adjusted exposure among industries China. Furthermore, marginal abatement cost per unit mass ISI-emitted only a quarter that other two sectors under scenarios. We highlight urgently required to achieve cost-effective reductions risks.

Язык: Английский

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Plastic Food Packaging from Five Countries Contains Endocrine- and Metabolism-Disrupting Chemicals

Environmental Science & Technology, Год журнала: 2024, Номер 58(11), С. 4859 - 4871

Опубликована: Март 5, 2024

Plastics are complex chemical mixtures of polymers and various intentionally nonintentionally added substances. Despite the well-established links between certain plastic chemicals (bisphenols phthalates) adverse health effects, composition toxicity real-world not well understood. To assess both, we analyzed from 36 food contact articles five countries using nontarget high-resolution mass spectrometry reporter-gene assays for four nuclear receptors that represent key components endocrine metabolic system. We found activating pregnane X receptor (PXR), peroxisome proliferator γ (PPARγ), estrogen α (ERα), inhibiting androgen (AR) prevalent in packaging. detected up to 9936 features a single product each had rather unique fingerprint. tackle this complexity, used stepwise partial least-squares regressions prioritized tentatively identified associated with activity. Our findings demonstrate most packaging contains endocrine- metabolism-disrupting chemicals. Since samples fewer induce less toxicity, simplification is producing safer

Язык: Английский

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Nanoconfined catalytic water purification within CoFeCu LDH-assembled membrane nanochannels

Applied Catalysis B Environment and Energy, Год журнала: 2024, Номер 357, С. 124290 - 124290

Опубликована: Июнь 11, 2024

Язык: Английский

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Decoding the exposome: Data science methodologies and implications in Exposome-Wide association studies (ExWASs)

Exposome, Год журнала: 2024, Номер unknown

Опубликована: Янв. 17, 2024

Abstract This paper explores the exposome concept and its role in elucidating interplay between environmental exposures human health. We introduce two key concepts critical for exposomics research. Firstly, we discuss joint impact of genetics environment on phenotypes, emphasizing variance attributable to shared non-shared factors, underscoring complexity quantifying exposome's influence health outcomes. Secondly, importance advanced data-driven methods large cohort studies exposomic measurements. Here, exposome-wide association study (ExWAS), an approach designed systematic discovery relationships phenotypes various exposures, identifying significant associations while controlling multiple comparisons. advocate standardized use term “exposome-wide study, ExWAS,” facilitate clear communication literature retrieval this field. The aims guide future researchers understanding evaluating studies. Our discussion extends emerging topics, such as FAIR Data Principles, biobanked healthcare datasets, functional exposome, outlining directions abstract provides a succinct overview our comprehensive complex dynamics implications

Язык: Английский

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