Fusobacterium nucleatum and cancer DOI Creative Commons
Tamar Alon‐Maimon, Ofer Mandelboim, Gilad Bachrach

и другие.

Periodontology 2000, Год журнала: 2022, Номер 89(1), С. 166 - 180

Опубликована: Март 4, 2022

Abstract Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is involved in progression of an increasing number tumors types. Thus far, mechanisms underlying tumor exacerbation by F. include enhancement proliferation, establishment a tumor‐promoting immune environment, induction chemoresistance, and activation checkpoints. This review focuses on mediate tumor‐specific colonization fusobacteria. Elucidating mediating fusobacterial tropism promotion might provide new insights for development novel approaches detection treatment.

Язык: Английский

The role of ROS in tumour development and progression DOI
Eric C. Cheung, Karen H. Vousden

Nature reviews. Cancer, Год журнала: 2022, Номер 22(5), С. 280 - 297

Опубликована: Янв. 31, 2022

Язык: Английский

Процитировано

1026

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer DOI Creative Commons
Jorge Luis Galeano Niño, Hanrui Wu, Kaitlyn D. LaCourse

и другие.

Nature, Год журнала: 2022, Номер 611(7937), С. 810 - 817

Опубликована: Ноя. 16, 2022

Abstract The tumour-associated microbiota is an intrinsic component of the tumour microenvironment across human cancer types 1,2 . Intratumoral host–microbiota studies have so far largely relied on bulk tissue analysis 1–3 , which obscures spatial distribution and localized effect within tumours. Here, by applying in situ spatial-profiling technologies 4 single-cell RNA sequencing 5 to oral squamous cell carcinoma colorectal cancer, we reveal spatial, cellular molecular host–microbe interactions. We adapted 10x Visium transcriptomics determine identity location intratumoral microbial communities patient tissues. Using GeoMx digital profiling 6 show that bacterial populate microniches are less vascularized, highly immuno‑suppressive associated with malignant cells lower levels Ki-67 as compared bacteria-negative regions. developed a RNA-sequencing method name INVADEseq (invasion–adhesion-directed expression sequencing) and, this tumours, identify cell-associated bacteria host they interact, well uncovering alterations transcriptional pathways involved inflammation, metastasis, dormancy DNA repair. Through functional studies, infected invade their surrounding environment single recruit myeloid Collectively, our data not random; instead, it organized immune epithelial functions promote progression.

Язык: Английский

Процитировано

487

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment DOI Creative Commons
Khiem C. Lam, Romina E. Araya, April Huang

и другие.

Cell, Год журнала: 2021, Номер 184(21), С. 5338 - 5356.e21

Опубликована: Окт. 1, 2021

Язык: Английский

Процитировано

393

Microbiome and cancer DOI Creative Commons
Nyssa Cullin, Camila Azevedo Antunes, Ravid Straussman

и другие.

Cancer Cell, Год журнала: 2021, Номер 39(10), С. 1317 - 1341

Опубликована: Сен. 9, 2021

Язык: Английский

Процитировано

380

Targeting the gut and tumor microbiota in cancer DOI
Elizabeth M. Park, Manoj Chelvanambi, Neal Bhutiani

и другие.

Nature Medicine, Год журнала: 2022, Номер 28(4), С. 690 - 703

Опубликована: Апрель 1, 2022

Язык: Английский

Процитировано

336

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions DOI Creative Commons
Lian Narunsky-Haziza, Gregory D. Sepich‐Poore, Ilana Livyatan

и другие.

Cell, Год журнала: 2022, Номер 185(20), С. 3789 - 3806.e17

Опубликована: Сен. 1, 2022

Cancer-microbe associations have been explored for centuries, but cancer-associated fungi rarely examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 types in four independent cohorts. We report fungal DNA cells at low abundances many major human cancers, with differences community compositions that differ among types, even when accounting technical background. Fungal histological staining of tissue microarrays supported intratumoral presence frequent spatial association macrophages. Comparing communities matched bacteriomes immunomes revealed co-occurring bi-domain ecologies, often permissive, rather than competitive, microenvironments distinct immune responses. Clinically focused assessments suggested prognostic diagnostic capacities mycobiomes, stage I synergistic predictive performance bacteriomes.

Язык: Английский

Процитировано

333

Meta-hallmarks of aging and cancer DOI Creative Commons
Carlos López‐Otín, Federico Pietrocola, David Roiz‐Valle

и другие.

Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 12 - 35

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

287

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors DOI Creative Commons

Anders B. Dohlman,

Jared Klug,

Marissa Mesko

и другие.

Cell, Год журнала: 2022, Номер 185(20), С. 3807 - 3822.e12

Опубликована: Сен. 1, 2022

Язык: Английский

Процитировано

248

Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial DOI
Bertrand Routy, John Lenehan, Wilson H. Miller

и другие.

Nature Medicine, Год журнала: 2023, Номер 29(8), С. 2121 - 2132

Опубликована: Июль 6, 2023

Язык: Английский

Процитировано

234

Engineering bacteria as interactive cancer therapies DOI
Candice R. Gurbatri, Nicholas Arpaia, Tal Danino

и другие.

Science, Год журнала: 2022, Номер 378(6622), С. 858 - 864

Опубликована: Ноя. 24, 2022

With increasing evidence that microbes colonize tumors, synthetic biology tools are being leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered systems can modulate the tumor microenvironment using a combination of their inherent immunogenicity and local payload production. Here, we review genetic circuits enhance spatial temporal control therapeutic improve safety efficacy. We describe engineering interactions among bacteria, cells, immune progression from single agents toward rational with other modalities. Together, these efforts building an emerging concept between programmable medicines biology.

Язык: Английский

Процитировано

226