Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Science, Год журнала: 2021, Номер 371(6529)

Опубликована: Янв. 6, 2021

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines assessing the likely future course of COVID-19 pandemic. We analyzed multiple compartments circulating SARS-CoV-2 in 254 samples from 188 cases, including 43 at ≥6 months after infection. Immunoglobulin G (IgG) spike protein was relatively stable over 6+ months. Spike-specific B cells were more abundant 6 than 1 month symptom onset. SARS-CoV-2-specific CD4

Язык: Английский

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Cytokine Storm

New England Journal of Medicine, Год журнала: 2020, Номер 383(23), С. 2255 - 2273

Опубликована: Дек. 2, 2020

Common Terminology Criteria for Adverse

Язык: Английский

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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Science, Год журнала: 2020, Номер 370(6515)

Опубликована: Сен. 24, 2020

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 987 patients with life-threatening disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), 13 types IFN-α (36), or both (52) onset critical disease; a few also auto-Abs other three type I IFNs. The neutralize ability corresponding IFNs to block SARS-CoV-2 vitro. These were not found 663 individuals asymptomatic mild and present only 4 1227 healthy individuals. Patients aged 25 87 years 95 men. A B cell autoimmune phenocopy inborn errors IFN immunity accounts for COVID-19 2.6% women 12.5%

Язык: Английский

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Adaptive immunity to SARS-CoV-2 and COVID-19

Cell, Год журнала: 2021, Номер 184(4), С. 861 - 880

Опубликована: Янв. 13, 2021

Язык: Английский

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Genetic mechanisms of critical illness in COVID-19

Nature, Год журнала: 2020, Номер 591(7848), С. 92 - 98

Опубликована: Дек. 11, 2020

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with may identify mechanistic targets for therapeutic development3. Here we report results of GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study 2,244 critically ill patients COVID-19 from 208 UK intensive care units. We have identified replicated following new significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 OAS3); 19p13.2 (rs74956615, 2.3 near tyrosine kinase 2 (TYK2); 19p13.3 (rs2109069, 3.98 10-12) within dipeptidyl peptidase 9 (DPP9); 21q22.1 (rs2236757, 4.99 interferon receptor IFNAR2. potential repurposing licensed medications: using Mendelian randomization, found evidence low expression IFNAR2, or high TYK2, are life-threatening disease; transcriptome-wide tissue revealed monocyte-macrophage chemotactic CCR2 severe COVID-19. Our robust signals relating to key host defence mechanisms mediators inflammatory organ damage Both be amenable targeted treatment existing drugs. However, large-scale randomized clinical trials will essential before any change practice.

Язык: Английский

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Risk factors for severe and critically ill COVID‐19 patients: A review

Allergy, Год журнала: 2020, Номер 76(2), С. 428 - 455

Опубликована: Ноя. 13, 2020

The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), has an unprecedented global social and economic impact, high numbers deaths. Many risk factors have been identified in progression COVID-19 into a critical stage, including old age, male gender, underlying comorbidities such as hypertension, diabetes, obesity, chronic lung diseases, heart, liver kidney tumors, clinically apparent immunodeficiencies, local early type I interferon secretion capacity, pregnancy. Possible complications include injury, coagulation disorders, thoromboembolism. development lymphopenia eosinopenia are laboratory indicators COVID-19. Laboratory parameters to monitor lactate dehydrogenase, procalcitonin, high-sensitivity C-reactive protein, proinflammatory cytokines interleukin (IL)-6, IL-1β, Krebs von den Lungen-6 (KL-6), ferritin. cytokine storm extensive chest computed tomography imaging patterns disease. In addition, socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day initiation treatment, quality health care reported influence individual outcomes. this review, we highlight scientific evidence on severity

Язык: Английский

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The T cell immune response against SARS-CoV-2

Nature Immunology, Год журнала: 2022, Номер 23(2), С. 186 - 193

Опубликована: Фев. 1, 2022

Язык: Английский

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COVID-19 and diabetes mellitus: from pathophysiology to clinical management

Nature Reviews Endocrinology, Год журнала: 2020, Номер 17(1), С. 11 - 30

Опубликована: Ноя. 13, 2020

Язык: Английский

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Mapping the human genetic architecture of COVID-19

Nature, Год журнала: 2021, Номер 600(7889), С. 472 - 477

Опубликована: Июль 8, 2021

The genetic make-up of an individual contributes to the susceptibility and response viral infection. Although environmental, clinical social factors have a role in chance exposure SARS-CoV-2 severity COVID-191,2, host genetics may also be important. Identifying host-specific reveal biological mechanisms therapeutic relevance clarify causal relationships modifiable environmental risk for infection outcomes. We formed global network researchers investigate human COVID-19 severity. Here we describe results three genome-wide association meta-analyses that consist up 49,562 patients with from 46 studies across 19 countries. report 13 significant loci are associated or severe manifestations COVID-19. Several these correspond previously documented associations lung autoimmune inflammatory diseases3-7. They represent potentially actionable Mendelian randomization analyses support smoking body-mass index although not type II diabetes. identification novel was made possible by community coming together prioritize sharing data, results, resources analytical frameworks. This working model international collaboration underscores what is future discoveries emerging pandemics, indeed any complex disease.

Язык: Английский

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Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee

Journal of Clinical Immunology, Год журнала: 2022, Номер 42(7), С. 1473 - 1507

Опубликована: Июнь 24, 2022

Abstract We report the updated classification of inborn errors immunity, compiled by International Union Immunological Societies Expert Committee. This documents key clinical and laboratory features 55 novel monogenic gene defects, 1 phenocopy due to autoantibodies, that have either been discovered since previous update (published January 2020) or were characterized earlier but confirmed expanded in subsequent studies. While variants additional genes associated with immune diseases reported literature, this includes only those committee assessed reached necessary threshold represent immunity. There are now a total 485 These advances discovering genetic causes human continue significantly further our understanding molecular, cellular, immunological mechanisms disease pathogenesis, thereby simultaneously enhancing knowledge improving patient diagnosis management. is designed serve as resource for immunologists geneticists pursuing molecular individuals heritable disorders scientific dissection cellular underlying related diseases.

Язык: Английский

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