Nanocomposite multifunctional hyaluronic acid hydrogel with photothermal antibacterial and antioxidant properties for infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 226, С. 870 - 884

Опубликована: Дек. 14, 2022

Язык: Английский

---

Antibacterial Pyrazoles: Tackling Resistant Bacteria

Future Medicinal Chemistry, Год журнала: 2022, Номер 14(5), С. 343 - 362

Опубликована: Янв. 20, 2022

Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic is a global concern, which spreads rapidly across borders continents due rapid travel of people, animals goods. Derivatives metabolically stable pyrazole nucleus are known for their wide range pharmacological properties, including antibacterial activities. This review highlights recent reports derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole target metabolic pathways both Gram-positive Gram-negative bacteria.

Язык: Английский

---

Michael acceptor molecules in natural products and their mechanism of action

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 2, 2022

Purpose: Michael receptor molecules derived from plants are biologically active due to electrophilic groups in their structure. They can target nucleophilic residues on disease-related proteins, with significant therapeutic effects and low toxicity for many diseases. provide a good option relevant disease treatment. The aim of this study is summarize the existing MAMs applications, lay foundation application life science future. Methods: This review summarizes published studies isolated literature databases such as CNKI, Wanfang Data, PubMed, Web Science, ScienceDirect, Wiley. Latin names were verified through https://www.iplant.cn/ . All compound structures PubChem literature, illustrated ChemDraw 20.0. Result: A total 50 various discussed. It was found that these compounds have similar pharmacological potential, most them play role Keap1-Nrf2-ARE pathway NF-κB pathway, biological activities antioxidant anti-inflammatory. be used treat inflammatory diseases tumors. Conclusion: molecule has electrophilicity its unsaturated aldehyde ketone structure, which combine protein form complexes activate or inhibit physiological role. regulate pathway. inflammation, cancer, oxidative stress, etc.

Язык: Английский

---

Multi‐Functional Bio‐HJzyme: Revolutionizing Diabetic Skin Regeneration with its Glucose‐Unlocked Sterilization and Programmed Anti‐Inflammatory Effects

Advanced Science, Год журнала: 2023, Номер 10(21)

Опубликована: Май 10, 2023

Abstract Antibacterial dynamic therapy (ADT) triggered by reactive oxygen species (ROS) is promising for diabetic infectious disease treatment. However, the limited local O 2 /H production and post‐treatment inflammation remain long‐standing issues. To address these challenges, a novel H ‐evolving bio‐heterojunction enzyme (Bio‐HJzyme) consisting of graphite‐phase carbon nitride/copper sulfide (CN/Cu 2− x S) heterojunction glucose oxidase (GO ) created. The Bio‐HJzyme offers glutathione peroxidase (GP ), (POD), catalase (CAT) mimetic activities; provides anti‐pathogen properties via programmed light activation; effectively promotes wound healing. Specifically, its GP ‐mimetic activity presence GO significantly enhance yield , which can be catalyzed through POD‐mimetic to produce highly germicidal •OH. also assisted CAT‐mimetic activity. products then into •OH •O − under NIR irradiation, giving enhanced ADT. Further, CN split water form solar light, dramatically suppresses caused excessive ROS. In vivo evaluation confirms that regeneration skin killing bacteria, enhancing angiogenesis, promoting bed epithelialization, reinforcing anti‐inflammatory responses; hence, providing revolutionary approach wounds

Язык: Английский

---

Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems

Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1188 - 1188

Опубликована: Апрель 7, 2023

Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are powerful weapon in the fight against bacteria. However, with widespread use of antibiotics, problem drug resistance now poses great threat to human health. In recent years, studies investigated approaches combat bacterial resistance. Several antimicrobial materials delivery systems emerged as promising strategies. Nano-drug for antibiotics can reduce extend lifespan novel they allow targeting compared conventional antibiotics. This review highlights mechanistic insights using different strategies drug-resistant bacteria summarizes advancements carriers. Furthermore, fundamental properties combating discussed, current challenges future perspectives this field proposed.

Язык: Английский

---

Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance

Trends in Microbiology, Год журнала: 2023, Номер 32(1), С. 93 - 104

Опубликована: Июль 19, 2023

Язык: Английский

---

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

Cells, Год журнала: 2023, Номер 12(23), С. 2684 - 2684

Опубликована: Ноя. 22, 2023

Hydrogen sulfide (H

Язык: Английский

---

Nicotinamide Mononucleotide Ameliorates Sleep Deprivation‐Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections

Advanced Science, Год журнала: 2023, Номер 10(9)

Опубликована: Янв. 25, 2023

Abstract Gut microbiota‐mediated colonization resistance (CR) is crucial in protecting the host from intestinal infections. Sleep deprivation (SD) an important contributor disturbances of homeostasis. However, whether and how SD affects CR remains largely unknown. Here, it shown that impairs mice, whereas nicotinamide mononucleotide (NMN) supplementation restores it. Microbial diversity metabolomic analyses suggest gut microbiota metabolite profiles SD‐treated mice are highly shaped, NMN reprograms these differences. Specifically, altered further incurs disorder secondary bile acids pool accompanied by a decrease deoxycholic acid (DCA). Conversely, retakes potential benefits DCA, which associated with specific involved primary metabolic flux. In animal models infection, DCA effective preventing treating bacterial infections when used alone or combination antibiotics. Mechanistically, disrupts membrane permeability aggravates oxidative damage, thereby reducing pathogen burden. Meanwhile, exogenous promotes antibiotic accumulation destroys oxidant–antioxidant system, thus potentiating efficacy. Overall, this work highlights roles metabolism maintenance CR.

Язык: Английский

---

Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance

Pharmacology & Therapeutics, Год журнала: 2023, Номер 252, С. 108550 - 108550

Опубликована: Окт. 30, 2023

Язык: Английский

---

Elaborated Bio‐Heterojunction With Robust Sterilization Effect for Infected Tissue Regeneration via Activating Competent Cell‐Like Antibacterial Tactic

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 13, 2024

Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO

Язык: Английский

---