Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

Journal of Hepatology, Год журнала: 2022, Номер 77(4), С. 1136 - 1160

Опубликована: Июнь 22, 2022

Язык: Английский

---

Pathogenesis of pneumonia and acute lung injury

Clinical Science, Год журнала: 2022, Номер 136(10), С. 747 - 769

Опубликована: Май 1, 2022

Abstract Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary critical care healthcare professionals, these have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One limitation translational investigation of including most severe manifestation (acute respiratory distress syndrome, ARDS) has been heterogeneity resulting from clinical physiologic diagnosis that represents a wide variety etiologies. Recent efforts improved our understanding approach by defining sub-phenotypes ARDS although significant gaps in knowledge remain. Improving mechanistic injury common cause, infectious pneumonia, can advance precision targeted interventions. Here, we review pathogenesis pneumonia how infections disrupt homoeostasis, provide an overview microbial pathogenesis, microbiome, interventions demonstrated improve outcomes—or not—in human trials.

Язык: Английский

---

Inflammation: the incubator of the tumor microenvironment

Trends in cancer, Год журнала: 2022, Номер 8(11), С. 901 - 914

Опубликована: Июль 28, 2022

Язык: Английский

---

Humoral Innate Immunity and Acute-Phase Proteins

New England Journal of Medicine, Год журнала: 2023, Номер 388(5), С. 439 - 452

Опубликована: Фев. 1, 2023

Язык: Английский

---

Molecular mechanisms of ferroptosis and relevance to inflammation

Inflammation Research, Год журнала: 2022, Номер 72(2), С. 281 - 299

Опубликована: Дек. 19, 2022

Язык: Английский

---

IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer

Nature, Год журнала: 2023, Номер 623(7986), С. 415 - 422

Опубликована: Ноя. 1, 2023

Язык: Английский

---

Obese visceral fat tissue inflammation: from protective to detrimental?

BMC Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Дек. 27, 2022

Abstract Obesity usually is accompanied by inflammation of fat tissue, with a prominent role visceral fat. Chronic in obese tissue lower grade than acute immune activation for clearing the from an infectious agent. It loss adipocyte metabolic homeostasis that causes resident cells supporting functions and regaining homeostasis. Initially, excess influx lipids glucose context overnutrition met growth proliferation. Eventual lipid overload hypertrophic adipocytes leads to endoplasmic reticulum stress secretion variety signals causing increased sympathetic tone, lipolysis adipocytes, uptake macrophages, matrix remodeling, angiogenesis, cell activation. Pro-inflammatory signaling system release amounts pro-inflammatory other mediators resulting enhanced tissue-protective responses. With chronic overnutrition, these protective actions are insufficient, death as well senescence several types seen. This structural damage expression or immunostimulatory components monocytes many types, contribution stromal cells. Matrix remodeling angiogenesis further intensified possibly detrimental fibrosis. The accumulation senescent also may be via eventual spread state affected neighboring microRNA-containing vesicles. Obese can viewed initially response order cope ambient nutrients restore but contribute at later stage.

Язык: Английский

---

Connecting aging biology and inflammation in the omics era

Journal of Clinical Investigation, Год журнала: 2022, Номер 132(14)

Опубликована: Июль 14, 2022

Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood solid tissues, termed inflammaging. Inflammaging has been implicated pathogenesis many age-associated chronic diseases as well loss physical cognitive function. The search for mechanisms underlie inflammaging focused initially on hallmarks aging, but it rapidly expanding multiple directions. Here, we discuss threads connecting cellular senescence mitochondrial dysfunction impaired mitophagy DNA damage, which may act hub We explore emerging multi-omics efforts aspire define complexity - identify molecular signatures novel targets interventions aimed at counteracting excessive inflammation its deleterious consequences while preserving physiological immune response. Finally, review evidence involved brain aging neurodegenerative diseases. Our goal broaden research agenda with an eye new therapeutic opportunities.

Язык: Английский

---

Inflammation and DNA damage: cause, effect or both

Nature Reviews Rheumatology, Год журнала: 2023, Номер 19(4), С. 200 - 211

Опубликована: Фев. 7, 2023

Язык: Английский

---

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Neuron, Год журнала: 2022, Номер 110(21), С. 3549 - 3565

Опубликована: Окт. 12, 2022

Язык: Английский

---