Meta-hallmarks of aging and cancer

Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 12 - 35

Опубликована: Янв. 1, 2023

Язык: Английский

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Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755

Опубликована: Июнь 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Язык: Английский

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SenNet recommendations for detecting senescent cells in different tissues

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(12), С. 1001 - 1023

Опубликована: Июнь 3, 2024

Язык: Английский

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Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 13, 2023

Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between (i) CD8 + CD4 T-cell (ii) gene expression signatures tracking longevity-associated immunocompetence mortality-associated inflammation. Profiles ~48,500 individuals collectively indicate some persons resist degradation both during aging when challenged varied stressors. With resistance, preservation tracked a lower risk HIV acquisition, AIDS development, symptomatic influenza infection, recurrent skin cancer; survival COVID-19 sepsis; (iii) longevity. potentially reversible by decreasing Overall, show trait observed across age spectrum, more common females, aligned specific immunocompetence-inflammation linked favorable immunity-dependent health outcomes. mechanisms have utility biomarkers for measuring improving

Язык: Английский

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The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap

Molecular Neurodegeneration, Год журнала: 2023, Номер 18(1)

Опубликована: Июнь 5, 2023

Abstract Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon has been identified a risk factor for Alzheimer’s disease. While role of chronic peripheral well characterized in context dementia and other conditions, less known about neurologic contribution acute inflammatory insults take place system. Herein, we define immune challenge form pathogen exposure (e.g., viral infection) or tissue damage surgery) causes large, yet time-limited, response. We provide overview clinical translational research examined connection between disease, focusing on three categories have received considerable attention recent years: infection, critical illness, surgery. Additionally, review neurobiological mechanisms which facilitate neural response to discuss potential blood–brain barrier components neuro-immune axis After highlighting knowledge gaps this area research, propose roadmap address methodological challenges, suboptimal study design, paucity transdisciplinary efforts thus far limited our understanding how pathogen- damage-mediated may contribute Finally, therapeutic approaches designed promote resolution be used following preserve brain health limit progression neurodegenerative pathology.

Язык: Английский

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Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 27, 2025

Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated shared biomarkers and pathological mechanisms. We systematically retrieved transcriptomic datasets from Gene Expression Omnibus database. These encompass a comparative analysis periodontium without PD placenta PE. Differentially Expressed Genes Analysis Weighted Go-expression Network (WGCNA) were used to identify key crosstalk genes in patients The functional characterisation these was performed using enrichment analysis. Protein–protein interaction networks machine learning methods leveraged hub genes. XG-Boost algorithm applied construct diagnostic models gain insight into disease aetiology. identified validated by single-cell RNA sequencing ensure robustness biological relevance. A total 55 identified, which primarily enriched immune-related pathways limma WGCNA. Among them, twenty-four protein–protein methods. model constructed outperformed other two (area under receiver operating characteristic curve [ROC] = 0.7786 0.7454 for PE PD, respectively). Pathways involving mapped Kyoto Encyclopedia Genomes In addition, showed expression BIN2, LYN, PIK3AP1, NEDD9 neutrophils significantly downregulated, LYN fibroblasts endothelial cells consistently upregulated. Shared immunologic characterised between NEDD9, suggesting pathogenesis could pave way development effective diagnostic, treatment, management strategies.

Язык: Английский

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Effect of Vitamin D₃ and Omega-3 Fatty Acid Supplementation on Risk of Frailty

JAMA Network Open, Год журнала: 2022, Номер 5(9), С. e2231206 - e2231206

Опубликована: Сен. 13, 2022

Importance

Preventive strategies for frailty are needed. Whether supplements with anti-inflammatory properties, such as vitamin D₃or marine omega-3 fatty acids, useful prevention is unknown.

Objective

To test the effects of D₃and on change in older individuals.

Design, Setting, and Participants

This study was conducted 2021, a prespecified ancillary to Vitamin D Omega-3 (VITAL) trial, 2 × factorial randomized clinical trial. A total 25 871 individuals (men aged ≥50 years women ≥55 years), without cancer or cardiovascular disease data frailty, were recruited across all 50 US states from November 2011 March 2014 followed up through December 31, 2017. Data analysis 1, 2019, 30, 2022.

Interventions

D₃, 2000 IU/d, 1 g/d.

Main Outcomes Measures

Frailty measured using validated 36-item index that includes measures function, cognition, mood, comorbidities annual questionnaires. Change score baseline year 5, according randomization, an intention-to-treat protocol, assessed repeated measures. Cox proportional hazards regression models incident frailty. In subgroup analysis, alternative definition, physical phenotype, used sensitivity analysis.

Results

Of VITAL trial participants randomized, 057 had sufficient calculate index. Baseline mean (SD) age 67.2 (7.0) years, 12 698 (50.7.%) women. Mean 0.109 (0.090) (range, 0.00-0.685), 3174 (12.7%) frail. During median 5-year follow-up, scores increased 0.121 (0.099) 0.00-0.792). Neither D₃nor acid supplementation affected over time (mean difference at 5: −0.0002;P = .85; acid, −0.0001;P .90) rate (interaction time: D₃;P .98; acid;P .13) Incident remained similar D₃,P .90; .32). Results unchanged phenotype.

Conclusions Relevance

this treatment supplementation, compared placebo, did not affect incidence time. These results do support routine use either generally healthy community-dwelling adults selected D₃deficiency.

Trial Registration

ClinicalTrials.gov Identifier:NCT01169259

Язык: Английский

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Aging and Inflammation

Cold Spring Harbor Perspectives in Medicine, Год журнала: 2023, Номер 14(6), С. a041197 - a041197

Опубликована: Дек. 5, 2023

Amit Singh1,6, Shepherd H. Schurman2,6, Arsun Bektas3, Mary Kaileh1, Roshni Roy1,5, David M. Wilson III4, Ranjan Sen1 and Luigi Ferrucci3 1Laboratory of Molecular Biology Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA 2Clinical Research Unit, 3Translational Gerontology Branch, 4Biomedical Institute, Hasselt University, Diepenbeek 3500, Belgium Correspondence: ferruccilu{at}grc.nia.nih.gov ↵6 These authors contributed equally to this work. ↵5 Present address: Department Microbiology Emory University School Medicine, Atlanta, Georgia 30322, USA.

Язык: Английский

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An Integrated Multi-Omics and Artificial Intelligence Framework for Advance Plant Phenotyping in Horticulture

Biology, Год журнала: 2023, Номер 12(10), С. 1298 - 1298

Опубликована: Сен. 30, 2023

This review discusses the transformative potential of integrating multi-omics data and artificial intelligence (AI) in advancing horticultural research, specifically plant phenotyping. The traditional methods phenotyping, while valuable, are limited their ability to capture complexity biology. advent (meta-)genomics, (meta-)transcriptomics, proteomics, metabolomics has provided an opportunity for a more comprehensive analysis. AI machine learning (ML) techniques can effectively handle volume data, providing meaningful interpretations predictions. Reflecting multidisciplinary nature this area review, readers will find collection state-of-the-art solutions that key integration phenotyping experiments horticulture, including experimental design considerations with several technical non-technical challenges, which discussed along solutions. future prospects include precision predictive breeding, improved disease stress response management, sustainable crop exploration biodiversity. holds immense promise revolutionizing research applications, heralding new era

Язык: Английский

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Dual cognitive and mobility impairments and future dementia ‐ Setting a research agenda

Alzheimer s & Dementia, Год журнала: 2023, Номер 19(4), С. 1579 - 1586

Опубликована: Янв. 13, 2023

Abstract Dual cognitive and mobility impairments are associated with an increased risk of dementia. Recent studies examining temporal trajectories function in aging found that dual decline is higher dementia than memory or gait only. Although initial data show individuals impairment have excessive cardiovascular metabolic factors, the causes what underlies a high remain largely unknown. In December 2021, National Institute on Aging Intramural Extramural Programs jointly organized workshop Biology Underlying Moving Thinking to explore hypothesis older persons may develop through specific pathophysiological pathway. The working group discussed assessment methods for possible mechanisms connecting pinpointed most critical questions be addressed from translational perspective.

Язык: Английский

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