Natural killer cells in antitumour adoptive cell immunotherapy

Nature reviews. Cancer, Год журнала: 2022, Номер 22(10), С. 557 - 575

Опубликована: Июль 25, 2022

Язык: Английский

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CAR immune cells: design principles, resistance and the next generation

Nature, Год журнала: 2023, Номер 614(7949), С. 635 - 648

Опубликована: Фев. 22, 2023

Язык: Английский

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Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

European Heart Journal, Год журнала: 2022, Номер 43(27), С. 2549 - 2561

Опубликована: Апрель 15, 2022

Abstract Most patients survive acute myocardial infarction (MI). Yet this encouraging development has certain drawbacks: heart failure (HF) prevalence is increasing and affected tend to have more comorbidities worsening economic strain on healthcare systems impeding effective medical management. The heart’s pathological changes in structure and/or function, termed remodelling, significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, female sex, others distinctly shape disease progression the ‘road HF’. Despite availability of HF drugs that interact with general pathways involved targeted remain absent, risk stratification poor. Hence, review, we highlight pathophysiological basis, current diagnostic methods available treatments for cardiac remodelling following MI. We further aim provide a roadmap developing improved novel interventional therapies.

Язык: Английский

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The landscape of mRNA nanomedicine

Nature Medicine, Год журнала: 2022, Номер 28(11), С. 2273 - 2287

Опубликована: Ноя. 1, 2022

Язык: Английский

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Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

Nature Reviews Materials, Год журнала: 2023, Номер 8(4), С. 282 - 300

Опубликована: Янв. 19, 2023

Язык: Английский

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Unlocking the promise of mRNA therapeutics

Nature Biotechnology, Год журнала: 2022, Номер 40(11), С. 1586 - 1600

Опубликована: Ноя. 1, 2022

Язык: Английский

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Therapeutic in vivo delivery of gene editing agents

Cell, Год журнала: 2022, Номер 185(15), С. 2806 - 2827

Опубликована: Июль 1, 2022

In vivo gene editing therapies offer the potential to treat root causes of many genetic diseases. Realizing promise therapeutic in requires ability safely and efficiently deliver agents relevant organs tissues vivo. Here, we review current delivery technologies that have been used enable editing, including viral vectors, lipid nanoparticles, virus-like particles. Since no single modality is likely be appropriate for every possible application, compare benefits drawbacks each method highlight opportunities future improvements.

Язык: Английский

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CAR T therapy beyond cancer: the evolution of a living drug

Nature, Год журнала: 2023, Номер 619(7971), С. 707 - 715

Опубликована: Июль 26, 2023

Язык: Английский

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The landscape of aging

Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454

Опубликована: Сен. 2, 2022

Язык: Английский

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mRNA-based cancer therapeutics

Nature reviews. Cancer, Год журнала: 2023, Номер 23(8), С. 526 - 543

Опубликована: Июнь 13, 2023

Язык: Английский

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