Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 14, 2023
Abstract
Cardiac
aging
is
evident
by
a
reduction
in
function
which
subsequently
contributes
to
heart
failure.
The
metabolic
microenvironment
has
been
identified
as
hallmark
of
malignancy,
but
recent
studies
have
shed
light
on
its
role
cardiovascular
diseases
(CVDs).
Various
pathways
cardiomyocytes
and
noncardiomyocytes
determine
cellular
senescence
the
heart.
Metabolic
alteration
common
process
throughout
cardiac
degeneration.
Importantly,
involvement
injuries,
including
failure
myocardial
ischemia
infarction,
reported.
However,
complexity
among
human
hearts
hinders
development
strategies
that
targets
susceptibility.
Advances
over
past
decade
linked
with
their
reprogramming
pathway
aging,
autophagy,
oxidative
stress,
epigenetic
modifications,
chronic
inflammation,
myocyte
systolic
phenotype
regulation.
In
addition,
status
involved
crucial
aspects
biology,
from
fibrosis
hypertrophy
inflammation.
further
elucidation
metabolism
degeneration
still
needed.
Thus,
deciphering
mechanisms
underlying
how
impacts
thought
contribute
novel
interventions
protect
or
even
restore
hearts.
Here,
we
summarize
emerging
concepts
about
landscapes
specific
focuses
why
profile
alters
during
could
utilize
current
knowledge
improve
management
aging.
European Heart Journal,
Journal Year:
2022,
Volume and Issue:
43(27), P. 2549 - 2561
Published: April 15, 2022
Abstract
Most
patients
survive
acute
myocardial
infarction
(MI).
Yet
this
encouraging
development
has
certain
drawbacks:
heart
failure
(HF)
prevalence
is
increasing
and
affected
tend
to
have
more
comorbidities
worsening
economic
strain
on
healthcare
systems
impeding
effective
medical
management.
The
heart’s
pathological
changes
in
structure
and/or
function,
termed
remodelling,
significantly
impact
patient
outcomes.
Risk
factors
like
diabetes,
chronic
obstructive
pulmonary
disease,
female
sex,
others
distinctly
shape
disease
progression
the
‘road
HF’.
Despite
availability
of
HF
drugs
that
interact
with
general
pathways
involved
targeted
remain
absent,
risk
stratification
poor.
Hence,
review,
we
highlight
pathophysiological
basis,
current
diagnostic
methods
available
treatments
for
cardiac
remodelling
following
MI.
We
further
aim
provide
a
roadmap
developing
improved
novel
interventional
therapies.
Cell,
Journal Year:
2022,
Volume and Issue:
185(15), P. 2806 - 2827
Published: July 1, 2022
In
vivo
gene
editing
therapies
offer
the
potential
to
treat
root
causes
of
many
genetic
diseases.
Realizing
promise
therapeutic
in
requires
ability
safely
and
efficiently
deliver
agents
relevant
organs
tissues
vivo.
Here,
we
review
current
delivery
technologies
that
have
been
used
enable
editing,
including
viral
vectors,
lipid
nanoparticles,
virus-like
particles.
Since
no
single
modality
is
likely
be
appropriate
for
every
possible
application,
compare
benefits
drawbacks
each
method
highlight
opportunities
future
improvements.
