Science China Life Sciences, Journal Year: 2022, Volume and Issue: 66(1), P. 12 - 30
Published: Sept. 8, 2022
Language: Английский
Science China Life Sciences, Journal Year: 2022, Volume and Issue: 66(1), P. 12 - 30
Published: Sept. 8, 2022
Language: Английский
Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(10), P. 557 - 575
Published: July 25, 2022
Language: Английский
Citations
490Nature, Journal Year: 2023, Volume and Issue: 614(7949), P. 635 - 648
Published: Feb. 22, 2023
Language: Английский
Citations
356European Heart Journal, Journal Year: 2022, Volume and Issue: 43(27), P. 2549 - 2561
Published: April 15, 2022
Abstract Most patients survive acute myocardial infarction (MI). Yet this encouraging development has certain drawbacks: heart failure (HF) prevalence is increasing and affected tend to have more comorbidities worsening economic strain on healthcare systems impeding effective medical management. The heart’s pathological changes in structure and/or function, termed remodelling, significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, female sex, others distinctly shape disease progression the ‘road HF’. Despite availability of HF drugs that interact with general pathways involved targeted remain absent, risk stratification poor. Hence, review, we highlight pathophysiological basis, current diagnostic methods available treatments for cardiac remodelling following MI. We further aim provide a roadmap developing improved novel interventional therapies.
Language: Английский
Citations
324Nature Medicine, Journal Year: 2022, Volume and Issue: 28(11), P. 2273 - 2287
Published: Nov. 1, 2022
Language: Английский
Citations
319Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(4), P. 282 - 300
Published: Jan. 19, 2023
Language: Английский
Citations
318Nature Biotechnology, Journal Year: 2022, Volume and Issue: 40(11), P. 1586 - 1600
Published: Nov. 1, 2022
Language: Английский
Citations
315Cell, Journal Year: 2022, Volume and Issue: 185(15), P. 2806 - 2827
Published: July 1, 2022
In vivo gene editing therapies offer the potential to treat root causes of many genetic diseases. Realizing promise therapeutic in requires ability safely and efficiently deliver agents relevant organs tissues vivo. Here, we review current delivery technologies that have been used enable editing, including viral vectors, lipid nanoparticles, virus-like particles. Since no single modality is likely be appropriate for every possible application, compare benefits drawbacks each method highlight opportunities future improvements.
Language: Английский
Citations
301Nature, Journal Year: 2023, Volume and Issue: 619(7971), P. 707 - 715
Published: July 26, 2023
Language: Английский
Citations
255Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(12), P. 2354 - 2454
Published: Sept. 2, 2022
Language: Английский
Citations
244Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(8), P. 526 - 543
Published: June 13, 2023
Language: Английский
Citations
233