Bacterial defences: mechanisms, evolution and antimicrobial resistance

Nature Reviews Microbiology, Год журнала: 2023, Номер 21(8), С. 519 - 534

Опубликована: Апрель 24, 2023

Язык: Английский

---

Metabolic exchanges are ubiquitous in natural microbial communities

Nature Microbiology, Год журнала: 2023, Номер 8(12), С. 2244 - 2252

Опубликована: Ноя. 23, 2023

Язык: Английский

---

Degradation of Cellulose and Hemicellulose by Ruminal Microorganisms

Microorganisms, Год журнала: 2022, Номер 10(12), С. 2345 - 2345

Опубликована: Ноя. 27, 2022

As major structural components of plant cell walls, cellulose and hemicellulose are degraded fermented by anaerobic microbes in the rumen to produce volatile fatty acids, main nutrient source for host. Cellulose degradation is carried out primarily specialist bacteria, with additional contributions from protists fungi, via a variety mechanisms. Hemicelluloses hydrolyzed cellulolytic bacteria generalist, non-cellulolytic microbes, largely extracellular enzymes. hydrolysis follows first-order kinetics its rate limited available substrate surface area. Nevertheless, at least an order magnitude more rapid than digesters, due near-obligatory adherence microbial cells surface, lack downstream inhibitory effects; host animal, fiber also enhanced unique process rumination. Cellulolytic hemicellulolytic exhibit intense competition amensalism, but they display mutualistic interactions other trophic levels. Collectively, fiber-degrading community displays functional redundancy, partial niche overlap, convergence catabolic pathways that all contribute stability ruminal fermentation. The superior hydrolytic fermentative capabilities degraders make them promising candidates several fermentation technologies.

Язык: Английский

---

Microbial interactions for nutrient acquisition in soil: Miners, scavengers, and carriers

Soil Biology and Biochemistry, Год журнала: 2023, Номер 188, С. 109215 - 109215

Опубликована: Окт. 24, 2023

Язык: Английский

---

Emergent coexistence in multispecies microbial communities

Science, Год журнала: 2023, Номер 381(6655), С. 343 - 348

Опубликована: Июль 20, 2023

Understanding the mechanisms that maintain microbial biodiversity is a critical aspiration in ecology. Past work on coexistence has largely focused species pairs, but it unclear whether pairwise isolation required for multispecies community. To address this question, we conducted hundreds of competition experiments among stably coexisting members 12 different enrichment communities vitro. determine outcomes these experiments, developed an automated image analysis pipeline to quantify abundances. We found competitive exclusion was most common outcome, and strongly hierarchical transitive. Because many coexist within stable community fail co-culture under identical conditions, concluded emergent phenomenon. This highlights importance context understanding origins complex ecosystems.

Язык: Английский

---

Rhizosphere bacterial interactions and impact on plant health

Current Opinion in Microbiology, Год журнала: 2023, Номер 73, С. 102297 - 102297

Опубликована: Март 30, 2023

The rhizosphere is a chemically complex environment that harbors strikingly diverse microbial community. past few decades have seen rapid growth in the body of literature on plant–microbe–microbe interactions and plant health. Thus, aim this paper to review current knowledge (specifically bacteria) how these influence microbiomes impact This article discusses (i) recruits beneficial bacteria ii) competition between mechanisms/weapons employed bacteria–bacteria shapes microbiome turn affects heath. discussion mainly focuses interference competition, characterized by production specialized metabolites (antibacterial compounds) exploitative where bacterial strain restricts competitor's access nutrients such as through secretion siderophores could allude cooperation. Understanding mechanisms plant–bacteria provide insights into manipulate for improved agricultural outcomes.

Язык: Английский

---

Inter-bacterial mutualism promoted by public goods in a system characterized by deterministic temperature variation

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 5, 2023

Abstract Mutualism is commonly observed in nature but not often reported for bacterial communities. Although abiotic stress thought to promote microbial mutualism, there a paucity of research this area. Here, we monitor communities quasi-natural composting system, where temperature variation (20 °C–70 °C) the main stress. Genomic analyses and culturing experiments provide evidence that selects slow-growing stress-tolerant strains (i.e., Thermobifida fusca Saccharomonospora viridis ), mutualistic interactions emerge between them remaining through sharing cobalamin. Comparison 3000 pairings reveals mutualism common (~39.1%) competition rare (~13.9%) pairs involving T. S. . Overall, our work provides insights into how high can favour reduce at both community species levels.

Язык: Английский

---

Microbiome composition modulates secondary metabolism in a multispecies bacterial community

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(42)

Опубликована: Окт. 10, 2022

Bacterial secondary metabolites are a major source of antibiotics and other bioactive compounds. In microbial communities, these molecules can mediate interspecies interactions responses to environmental change. Despite the importance in human health ecology, little is known about their roles regulation context multispecies communities. simplified model rhizosphere composed Bacillus cereus , Flavobacterium johnsoniae Pseudomonas koreensis we show that dynamics metabolism depend on community species composition interactions. Comparative metatranscriptomics metametabolomics reveal abundance transcripts biosynthetic gene clusters (BGCs) metabolomic molecular features differ between monocultures or dual cultures tripartite community. both two- three-member cocultures, P. modified expression BGCs for zwittermicin, petrobactin, B. F. johnsoniae, whereas BGC transcriptional response itself was minimal. Pairwise cocultures with displayed unique appear be derivatives lokisin, suggesting metabolic handoffs species. Deleting koreenceine, another metabolite, altered transcript metabolite profiles across community, including substantial up-regulation petrobactin bacillibactin koreenceine represses siderophore production. Results from this bacterial chemical output identity capacity coculture partners, microbiome may shape nature.

Язык: Английский

---

Deterministic Effect of pH on Shaping Soil Resistome Revealed by Metagenomic Analysis

Environmental Science & Technology, Год журнала: 2023, Номер 57(2), С. 985 - 996

Опубликована: Янв. 5, 2023

Soil is recognized as the major reservoir of antibiotic resistance genes (ARGs), harboring most diverse naturally evolved ARGs on planet. Multidrug are a class ARGs, and their high prevalence in natural soil ecosystems has recently raised concerns. Since these express proton motive force (PMF) driven efflux pumps, studying whether pH determinant for selection multidrug pump thus shaping resistome great interest. In this study, we collected 108 soils with values ranging from 4.37 to 9.69 multiple profiled composition metagenomes metagenome-assembled genomes. We observed enriched acidic resistome, abundances have significant dependence. This reflects benefits activity genes, especially PMF-driven inner membrane transferase. addition, preliminary indicate putative microbial participants by applying ecological analyzing tools such stepwise regression random forest model fitting. The decisive influence more impactful than any other examined factors, consequence, revisited edaphic factors resistome; i.e., deterministic mechanisms could lead bottom-up ARG composition. Such developing herein suggested be considered assessing human-driven transmissions.

Язык: Английский

---

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

---