Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association

Stroke, Год журнала: 2024, Номер 55(12)

Опубликована: Окт. 10, 2024

The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public priority major challenge. Cardiovascular diseases are leading cause death disability United States around world. Emerging evidence shows that heart brain, once considered unrelated organ systems, interdependent linked through shared risk factors. More recently, studies designed unravel intricate pathogenic mechanisms underpinning this association show people with various cardiac conditions may have covert microstructural changes cognitive impairment. These findings given rise idea by addressing cardiovascular earlier life, it be possible reduce deter onset or progression impairment later life. Previous scientific statements addressed between stroke. This statement discusses link 3 prevalent adults (heart failure, atrial fibrillation, coronary disease)

Язык: Английский

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Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance

National Science Review, Год журнала: 2024, Номер 11(9)

Опубликована: Июнь 29, 2024

ABSTRACT Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity nuclear magnetic resonance (NMR) and imaging (MRI). Dynamic polarization (DNP), among various hyperpolarization methods, has gained prominence for its efficacy in real-time monitoring metabolism physiology. By administering hyperpolarized substrate through dissolution DNP (dDNP), biodistribution metabolic changes agent can be visualized spatiotemporally. This approach proves to distinctive invaluable tool non-invasively studying cellular vivo, particularly animal models. Biomarkers play pivotal role influencing growth metastasis tumor cells by closely interacting with them, accordingly detecting pathological alterations these biomarkers is crucial disease diagnosis therapy. In recent years, range molecular bioresponsive agents utilizing nuclei, such 13C, 15N, 31P, 89Y, etc., have been developed. this context, we explore how signals spins enhanced respond biomarkers, including pH, metal ions, enzymes, or redox processes. review aims offer insights into design principles responsive agents, target selection, mechanisms action imaging. Such discussions aim propel future development application DNP-based biomedical agents.

Язык: Английский

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Brain, lifestyle and environmental pathways linking physical and mental health

Nature Mental Health, Год журнала: 2024, Номер 2(10), С. 1250 - 1261

Опубликована: Авг. 9, 2024

Язык: Английский

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Neural Mechanisms in Cardiovascular Health and Disease

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1233 - 1261

Опубликована: Май 22, 2025

Although the neurocardiac axis is central to cardiovascular homeostasis, its dysregulation drives heart failure and cardiometabolic diseases. This review examines bidirectional interplay between autonomic nervous system heart, highlighting role of this in disease progression therapeutic potential. The modulates cardiac function vascular tone through sympathetic parasympathetic branches. However, failure, chronic overdrive withdrawal exacerbate myocardial remodeling metabolic dysfunction, both which are exacerbated by conditions such as obesity diabetes. These increasingly recognized impair regulation, thereby promoting inflammation adverse outcomes. An important emerging area concerns neuroimmune control, brain orchestrates systemic circuits involving bone marrow, spleen, other organs, amplifying damage. integrates peripheral signals influence immune responses that contribute progression. Lifestyle factors, stress, sleep, exercise, diet, affect balance and, thus, disease. Therapeutically, targeting pathways pharmacologically or via neuromodulation (eg, vagal splenic nerve stimulation) offers promise although clinical translation latter remains challenging. In review, we synthesize preclinical data highlight a critical nexus Harnessing interactions may inform precision approaches reduce burden these conditions.

Язык: Английский

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Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1719 - 1719

Опубликована: Авг. 1, 2024

Arrhythmias and depression are recognized as diseases of the heart brain, respectively, both major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves crucial component heart–brain axis (HBA) pathway interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress precipitate arrhythmias via ANS. However, HBA interoception frameworks considered overly broad, precise mechanisms underlying relationship between remain unclear. This narrative review aims to synthesize existing literature, focusing on pathological ANS in arrhythmia integrating other potential detail interactions. In communication we emphasize considering various internal factors such genes, personality traits, stress, endocrine system, inflammation, 5-hydroxytryptamine, behavioral factors. Current research employs multidisciplinary knowledge elucidate relationships, deeper understanding these interactions help optimize clinical treatment strategies. From broader perspective, this study emphasizes importance body complex, interconnected rather than treating organs isolation. Investigating enhance our disease pathogenesis advances medical science, ultimately improving human quality life.

Язык: Английский

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The Genetic Architecture of Biological Age in Nine Human Organ Systems

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 12, 2023

Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed BAG-organ specificity inter-organ connections. Genetic variants associated with BAGs are predominantly specific respective system while exerting pleiotropic effects on traits multiple A gene-drug-disease network confirmed involvement metabolic BAG-associated genes drugs targeting various disorders. correlation analyses supported Cheverud’s Conjecture 1 – between mirrors their phenotypic correlation. causal revealed potential linking chronic diseases (e.g., Alzheimer’s disease), body weight, sleep duration BAG Our findings shed light promising interventions enhance health within a complex network, including lifestyle modifications drug repositioning strategies treating diseases. All results publicly available at https://labs-laboratory.com/medicine .

Язык: Английский

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Cardiovascular disease risk models and dementia or cognitive decline: a systematic review

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Окт. 12, 2023

Background Health cognitive promotion and protection is a critical topic. With the world’s aging population rising life expectancy, there will be many people living with highly age-related dementia illnesses. Cardiovascular disease (CVD) share same risk factors, such as unhealthy lifestyles metabolic factors. These recognized risks associated CVD frequently co-occur. models may have close association decline. So, this systematic review aimed to determine whether were connected or decline compare predictive ability of various models. Methods PubMed, Web Science, PsychINFO, Embase, Cochrane Library, CNKI, Sinomed, WanFang searched from 1 January 2014 until 16 February 2023. Only included. We used Newcastle-Ottawa scale (NOS) for quality assessment included cohort studies Agency Healthcare Research Quality (AHRQ) cross-sectional studies. The Preferred Reporting Items Systematic Reviews Meta-analysis (PRISMA) statement’s guidelines followed in study. Results In all, 9,718 references screened, which 22 articles A total 15 summarized. Except Ambulatory Care Team (CANHEART) health index, other 14 comparison, different domain-specific function correlation variation depended on characteristics, models, tests, study designs. Moreover, it needed clarified when comparing predicting performance Conclusion It significant public improve prediction prevention mitigate potential adverse effects heart brain. More are warranted prove between function. further encouraged efficacy disorders.

Язык: Английский

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Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 17, 2023

Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from multimodal magnetic resonance (MRI), many which involved in pathways, including primary cortex. In 65 genomic regions, shared influences with diseases complex traits, 18 showing more overlaps MRI traits. Mendelian randomization suggests that have bidirectional causal neurological neuropsychiatric such as Alzheimer’s disease. Overall, genetics reveals basis connections, suggesting images can elucidate risk factors disorders disease-related changes intracranial

Язык: Английский

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Towards interpretable imaging genomics analysis: Methodological developments and applications

Information Fusion, Год журнала: 2023, Номер 102, С. 102032 - 102032

Опубликована: Сен. 19, 2023

Язык: Английский

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Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation

Molecular Psychiatry, Год журнала: 2024, Номер 29(6), С. 1857 - 1868

Опубликована: Фев. 9, 2024

Язык: Английский

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