Nature Genetics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Stroke, Год журнала: 2024, Номер 55(12)
Опубликована: Окт. 10, 2024
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public priority major challenge. Cardiovascular diseases are leading cause death disability United States around world. Emerging evidence shows that heart brain, once considered unrelated organ systems, interdependent linked through shared risk factors. More recently, studies designed unravel intricate pathogenic mechanisms underpinning this association show people with various cardiac conditions may have covert microstructural changes cognitive impairment. These findings given rise idea by addressing cardiovascular earlier life, it be possible reduce deter onset or progression impairment later life. Previous scientific statements addressed between stroke. This statement discusses link 3 prevalent adults (heart failure, atrial fibrillation, coronary disease)
Язык: Английский
Процитировано
9
National Science Review, Год журнала: 2024, Номер 11(9)
Опубликована: Июнь 29, 2024
ABSTRACT Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity nuclear magnetic resonance (NMR) and imaging (MRI). Dynamic polarization (DNP), among various hyperpolarization methods, has gained prominence for its efficacy in real-time monitoring metabolism physiology. By administering hyperpolarized substrate through dissolution DNP (dDNP), biodistribution metabolic changes agent can be visualized spatiotemporally. This approach proves to distinctive invaluable tool non-invasively studying cellular vivo, particularly animal models. Biomarkers play pivotal role influencing growth metastasis tumor cells by closely interacting with them, accordingly detecting pathological alterations these biomarkers is crucial disease diagnosis therapy. In recent years, range molecular bioresponsive agents utilizing nuclei, such 13C, 15N, 31P, 89Y, etc., have been developed. this context, we explore how signals spins enhanced respond biomarkers, including pH, metal ions, enzymes, or redox processes. review aims offer insights into design principles responsive agents, target selection, mechanisms action imaging. Such discussions aim propel future development application DNP-based biomedical agents.
Язык: Английский
Процитировано
8
Nature Mental Health, Год журнала: 2024, Номер 2(10), С. 1250 - 1261
Опубликована: Авг. 9, 2024
Язык: Английский
Процитировано
7
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1719 - 1719
Опубликована: Авг. 1, 2024
Arrhythmias and depression are recognized as diseases of the heart brain, respectively, both major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves crucial component heart–brain axis (HBA) pathway interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress precipitate arrhythmias via ANS. However, HBA interoception frameworks considered overly broad, precise mechanisms underlying relationship between remain unclear. This narrative review aims to synthesize existing literature, focusing on pathological ANS in arrhythmia integrating other potential detail interactions. In communication we emphasize considering various internal factors such genes, personality traits, stress, endocrine system, inflammation, 5-hydroxytryptamine, behavioral factors. Current research employs multidisciplinary knowledge elucidate relationships, deeper understanding these interactions help optimize clinical treatment strategies. From broader perspective, this study emphasizes importance body complex, interconnected rather than treating organs isolation. Investigating enhance our disease pathogenesis advances medical science, ultimately improving human quality life.
Язык: Английский
Процитировано
6
Molecular Psychiatry, Год журнала: 2024, Номер 29(6), С. 1857 - 1868
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
5
Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(4), С. 69 - 69
Опубликована: Апрель 1, 2024
This Opinion piece discusses several key research questions in health neuroscience, a new interdisciplinary field that investigates how the brain and body interact to affect our behavior such as mindsets, decision-making, actions, outcomes across lifespan. To achieve physical, mental, cognitive health, promote change, we propose prevention treatment of diseases should target root causes—the dysfunction imbalance brain-body biomarkers, through evidence-based body-mind interventions mindfulness meditation Tai Chi, rather than dealing with each symptom or disorder isolation various approaches.
Язык: Английский
Процитировано
5
Building and Environment, Год журнала: 2024, Номер 267, С. 112171 - 112171
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
5
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июнь 12, 2023
Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed BAG-organ specificity inter-organ connections. Genetic variants associated with BAGs are predominantly specific respective system while exerting pleiotropic effects on traits multiple A gene-drug-disease network confirmed involvement metabolic BAG-associated genes drugs targeting various disorders. correlation analyses supported Cheverud’s Conjecture 1 – between mirrors their phenotypic correlation. causal revealed potential linking chronic diseases (e.g., Alzheimer’s disease), body weight, sleep duration BAG Our findings shed light promising interventions enhance health within a complex network, including lifestyle modifications drug repositioning strategies treating diseases. All results publicly available at https://labs-laboratory.com/medicine .
Язык: Английский
Процитировано
13
Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15
Опубликована: Окт. 12, 2023
Background Health cognitive promotion and protection is a critical topic. With the world’s aging population rising life expectancy, there will be many people living with highly age-related dementia illnesses. Cardiovascular disease (CVD) share same risk factors, such as unhealthy lifestyles metabolic factors. These recognized risks associated CVD frequently co-occur. models may have close association decline. So, this systematic review aimed to determine whether were connected or decline compare predictive ability of various models. Methods PubMed, Web Science, PsychINFO, Embase, Cochrane Library, CNKI, Sinomed, WanFang searched from 1 January 2014 until 16 February 2023. Only included. We used Newcastle-Ottawa scale (NOS) for quality assessment included cohort studies Agency Healthcare Research Quality (AHRQ) cross-sectional studies. The Preferred Reporting Items Systematic Reviews Meta-analysis (PRISMA) statement’s guidelines followed in study. Results In all, 9,718 references screened, which 22 articles A total 15 summarized. Except Ambulatory Care Team (CANHEART) health index, other 14 comparison, different domain-specific function correlation variation depended on characteristics, models, tests, study designs. Moreover, it needed clarified when comparing predicting performance Conclusion It significant public improve prediction prevention mitigate potential adverse effects heart brain. More are warranted prove between function. further encouraged efficacy disorders.
Язык: Английский
Процитировано
13
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Фев. 17, 2023
Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from multimodal magnetic resonance (MRI), many which involved in pathways, including primary cortex. In 65 genomic regions, shared influences with diseases complex traits, 18 showing more overlaps MRI traits. Mendelian randomization suggests that have bidirectional causal neurological neuropsychiatric such as Alzheimer’s disease. Overall, genetics reveals basis connections, suggesting images can elucidate risk factors disorders disease-related changes intracranial
Язык: Английский
Процитировано
12