Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study

Hypertension, Journal Year: 2024, Volume and Issue: 81(5), P. 1132 - 1144

Published: March 15, 2024

This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.

Language: Английский

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Brain, lifestyle and environmental pathways linking physical and mental health

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(10), P. 1250 - 1261

Published: Aug. 9, 2024

Language: Английский

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Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(6), P. 1857 - 1868

Published: Feb. 9, 2024

Language: Английский

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Health Neuroscience—How the Brain/Mind and Body Affect our Health Behavior and Outcomes

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 69 - 69

Published: April 1, 2024

This Opinion piece discusses several key research questions in health neuroscience, a new interdisciplinary field that investigates how the brain and body interact to affect our behavior such as mindsets, decision-making, actions, outcomes across lifespan. To achieve physical, mental, cognitive health, promote change, we propose prevention treatment of diseases should target root causes—the dysfunction imbalance brain-body biomarkers, through evidence-based body-mind interventions mindfulness meditation Tai Chi, rather than dealing with each symptom or disorder isolation various approaches.

Language: Английский

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Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1719 - 1719

Published: Aug. 1, 2024

Arrhythmias and depression are recognized as diseases of the heart brain, respectively, both major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves crucial component heart–brain axis (HBA) pathway interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress precipitate arrhythmias via ANS. However, HBA interoception frameworks considered overly broad, precise mechanisms underlying relationship between remain unclear. This narrative review aims to synthesize existing literature, focusing on pathological ANS in arrhythmia integrating other potential detail interactions. In communication we emphasize considering various internal factors such genes, personality traits, stress, endocrine system, inflammation, 5-hydroxytryptamine, behavioral factors. Current research employs multidisciplinary knowledge elucidate relationships, deeper understanding these interactions help optimize clinical treatment strategies. From broader perspective, this study emphasizes importance body complex, interconnected rather than treating organs isolation. Investigating enhance our disease pathogenesis advances medical science, ultimately improving human quality life.

Language: Английский

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Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 17, 2023

Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from multimodal magnetic resonance (MRI), many which involved in pathways, including primary cortex. In 65 genomic regions, shared influences with diseases complex traits, 18 showing more overlaps MRI traits. Mendelian randomization suggests that have bidirectional causal neurological neuropsychiatric such as Alzheimer’s disease. Overall, genetics reveals basis connections, suggesting images can elucidate risk factors disorders disease-related changes intracranial

Language: Английский

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The Genetic Architecture of Biological Age in Nine Human Organ Systems

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 12, 2023

Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed BAG-organ specificity inter-organ connections. Genetic variants associated with BAGs are predominantly specific respective system while exerting pleiotropic effects on traits multiple A gene-drug-disease network confirmed involvement metabolic BAG-associated genes drugs targeting various disorders. correlation analyses supported Cheverud’s Conjecture 1 – between mirrors their phenotypic correlation. causal revealed potential linking chronic diseases (e.g., Alzheimer’s disease), body weight, sleep duration BAG Our findings shed light promising interventions enhance health within a complex network, including lifestyle modifications drug repositioning strategies treating diseases. All results publicly available at https://labs-laboratory.com/medicine .

Language: Английский

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Cardiovascular disease risk models and dementia or cognitive decline: a systematic review

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Oct. 12, 2023

Background Health cognitive promotion and protection is a critical topic. With the world’s aging population rising life expectancy, there will be many people living with highly age-related dementia illnesses. Cardiovascular disease (CVD) share same risk factors, such as unhealthy lifestyles metabolic factors. These recognized risks associated CVD frequently co-occur. models may have close association decline. So, this systematic review aimed to determine whether were connected or decline compare predictive ability of various models. Methods PubMed, Web Science, PsychINFO, Embase, Cochrane Library, CNKI, Sinomed, WanFang searched from 1 January 2014 until 16 February 2023. Only included. We used Newcastle-Ottawa scale (NOS) for quality assessment included cohort studies Agency Healthcare Research Quality (AHRQ) cross-sectional studies. The Preferred Reporting Items Systematic Reviews Meta-analysis (PRISMA) statement’s guidelines followed in study. Results In all, 9,718 references screened, which 22 articles A total 15 summarized. Except Ambulatory Care Team (CANHEART) health index, other 14 comparison, different domain-specific function correlation variation depended on characteristics, models, tests, study designs. Moreover, it needed clarified when comparing predicting performance Conclusion It significant public improve prediction prevention mitigate potential adverse effects heart brain. More are warranted prove between function. further encouraged efficacy disorders.

Language: Английский

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Towards interpretable imaging genomics analysis: Methodological developments and applications

Information Fusion, Journal Year: 2023, Volume and Issue: 102, P. 102032 - 102032

Published: Sept. 19, 2023

Language: Английский

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Associations of long-term exposure to low-level PM2.5 and brain disorders in 260,922 middle-aged and older adults

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142703 - 142703

Published: June 25, 2024

Language: Английский

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