The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

Science, Год журнала: 2022, Номер 377(6609), С. 951 - 959

Опубликована: Июль 26, 2022

Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market Wuhan, China, was identified as a likely source of cases early reports, but later this conclusion became controversial. We show here that earliest known COVID-19 from December 2019, including those without reported direct links, were geographically centered on market. report live SARS-CoV-2–susceptible mammals sold at market late and within market, SARS-CoV-2–positive environmental samples spatially associated with vendors selling mammals. Although there insufficient evidence define upstream events, exact circumstances remain obscure, our analyses indicate emergence SARS-CoV-2 occurred through wildlife trade China epicenter

Язык: Английский

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Pandemic origins and a One Health approach to preparedness and prevention: Solutions based on SARS-CoV-2 and other RNA viruses

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(42)

Опубликована: Окт. 10, 2022

COVID-19 is the latest zoonotic RNA virus epidemic of concern. Learning how it began and spread will help to determine reduce risk future events. We review major outbreaks since 1967 identify common features opportunities prevent emergence, including ancestral viral origins in birds, bats, other mammals; animal reservoirs intermediate hosts; pathways for spillover community spread, leading local, regional, or international outbreaks. The increasing scientific evidence concerning Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) most consistent with a origin pathway from wildlife people via farming trade. apply what we know about these relevant, feasible, implementable interventions. three primary targets pandemic prevention preparedness: first, smart surveillance coupled epidemiological assessment across wildlife–livestock–human (One Health) interfaces; second, research enhance preparedness expedite development vaccines therapeutics; third, strategies underlying drivers influence misinformation. For all three, continued efforts improve integrate biosafety biosecurity implementation One Health approach are essential. discuss new models address challenges creating an inclusive effective governance structure, necessary stable funding cross-disciplinary collaborative research. Finally, offer recommendations feasible actions close knowledge gaps continuum response future.

Язык: Английский

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After 2 years of the COVID-19 pandemic, translating One Health into action is urgent

The Lancet, Год журнала: 2022, Номер 401(10378), С. 789 - 794

Опубликована: Окт. 24, 2022

Язык: Английский

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Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 3, 2023

Abstract Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported in immune-compromised individuals and people undergoing immune-modulatory treatments. Although intrahost evolution has documented, direct evidence of subsequent transmission continued stepwise adaptation is lacking. Here we describe sequential persistent SARS-CoV-2 three that led to the emergence, forward transmission, a new Omicron sublineage, BA.1.23, over an eight-month period. The initially transmitted BA.1.23 variant encoded seven additional amino acid substitutions within spike protein (E96D, R346T, L455W, K458M, A484V, H681R, A688V), displayed substantial resistance neutralization by sera from boosted and/or BA.1-infected study participants. Subsequent replication resulted (S254F, N448S, F456L, M458K, F981L, S982L) as well five other virus proteins. Our findings demonstrate not only BA.1 lineage can diverge further its already exceptionally mutated genome but also patients with transmit these viral variants. Thus, there is, urgent need implement strategies prevent prolonged limit spread newly emerging, neutralization-resistant variants vulnerable patients.

Язык: Английский

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Global SARS-CoV-2 genomic surveillance: What we have learned (so far)

Infection Genetics and Evolution, Год журнала: 2023, Номер 108, С. 105405 - 105405

Опубликована: Янв. 18, 2023

The COVID-19 pandemic has brought significant challenges for genomic surveillance strategies in public health systems worldwide. During the past thirty-four months, many countries faced several epidemic waves of SARS-CoV-2 infections, driven mainly by emergence and spread novel variants. In that line, been a crucial toolkit to study real-time evolution, assessment optimization diagnostic assays, improve efficacy existing vaccines. pandemic, identification emerging lineages carrying lineage-specific mutations (particularly those Receptor Binding domain) showed how these might significantly impact viral transmissibility, protection from reinfection vaccination. So far, an unprecedented number genomes released databases (i.e., GISAID, NCBI), achieving 14 million genome sequences available as early-November 2022. present review, we summarise global landscape during first months circulation evolution. It demonstrates urgency importance sustained investment timely identify any potential pathogen or associated variants, which turn is key preparedness.

Язык: Английский

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Surveillance of SARS-CoV-2 at the Huanan Seafood Market

Nature, Год журнала: 2023, Номер 631(8020), С. 402 - 408

Опубликована: Апрель 5, 2023

Язык: Английский

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Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 28, 2023

Abstract The zoonotic origin of the COVID-19 pandemic virus highlights need to fill vast gaps in our knowledge SARS-CoV-2 ecology and evolution non-human hosts. Here, we detected that was introduced from humans into white-tailed deer more than 30 times Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds kilometers. Newly developed Bayesian phylogenetic methods quantified how is not only three-times faster compared rate observed but also driven by different mutational biases selection pressures. long-term effect this accelerated evolutionary remains be seen as no critical phenotypic changes were animal models using viruses. Still, has transmitted populations a relatively short duration, risk future may have serious consequences livestock.

Язык: Английский

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The Emergence and Evolution of SARS-CoV-2

Annual Review of Virology, Год журнала: 2024, Номер 11(1), С. 21 - 42

Опубликована: Апрель 18, 2024

The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet seemingly little resolution. I review the scientific evidence on its subsequent spread through human population. available data clearly point to a natural zoonotic emergence within, or closely linked to, Huanan Seafood Wholesale Market in Wuhan. There is no direct linking laboratory work conducted at Wuhan Institute Virology. global was characterized by gradual adaptation humans, with dual increases transmissibility virulence until Omicron variant. Of note been frequent transmission from humans other animals, marking it as strongly host generalist virus. Unless lessons are learned, inevitable that more events leading epidemics pandemics will plague populations.

Язык: Английский

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Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic

Cell, Год журнала: 2024, Номер 187(19), С. 5468 - 5482.e11

Опубликована: Сен. 1, 2024

Язык: Английский

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Pathogens and planetary change

Опубликована: Янв. 15, 2025

Emerging infectious diseases, biodiversity loss, and anthropogenic environmental change are interconnected crises with massive social ecological costs. In this Review, we discuss how pathogens parasites responding to global change, the implications for pandemic prevention conservation. Ecological evolutionary principles help explain why both pandemics wildlife die-offs becoming more common; land-use loss often followed by an increase in zoonotic vector-borne diseases; some species, such as bats, host so many emerging pathogens. To prevent next pandemic, scientists should focus on monitoring limiting spread of a handful high-risk viruses, especially at key interfaces farms live-animal markets. But address much broader set disease risks associated Anthropocene, decision-makers will need develop comprehensive strategies that include pathogen surveillance across species ecosystems; conservation-based interventions reduce human–animal contact protect health; health system strengthening; improvements epidemic preparedness response. Scientists can contribute these efforts filling gaps data, expanding evidence base disease–driver relationships interventions. This Review explores relationship between diseases connected changes Anthropocene.

Язык: Английский

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