Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 18, 2024
Abstract
The
combination
of
palladium
and
silver
complexes
has
emerged
as
a
bimetallic
catalytic
system
in
C−H
activation,
frequently
outperforming
palladium‐only
systems.
Beyond
the
conventional
roles
(I)
salts
serving
oxidants,
halide
scavengers,
Lewis
acids,
Pd−Ag
synergism
been
shown
to
facilitate
cleavage.
In
this
study,
we
explore
incorporation
pyrazolopyridone
(PzPyOH)
ligand
into
system,
which
together
promote
both
cleavage
migratory
insertion
processes.
This
synergistic
approach
enables
dehydrogenative
alkenylations
at
C4
position
2,1,3‐benzothiadiazole,
2,1,3‐benzoxadiazole,
2,1,3‐benzotriazole
with
alkenes.
These
results
demonstrate
potential
combining
novel
ligands
heterobimetallic
systems
other
elementary
steps
beyond
cleavage,
suggesting
their
broader
applicability
functionalization.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(4)
Опубликована: Окт. 23, 2023
The
oxidant-controlled
divergent
synthesis
of
C-2'
formyl
2H-indazoles
and
indazoloindazolediones
has
been
developed
through
Mn(I)-
catalyzed
ortho
C-H
functionalization
with
para-formaldehyde
to
afford
hydroxymethylated
subsequently
oxidation
varying
the
amount
DDQ
in
one-pot.
By
employing
selectfluor
as
oxidant
instead
DDQ,
this
reaction
exclusively
provided
indazolebenzoxazine
derivatives.
This
strategy
delivered
unsymmetrical
indazoloindazoledione
indazolobenzoxazine
varied
functional
group
tolerance
moderate
good
yields.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(17), С. 4388 - 4393
Опубликована: Янв. 1, 2023
We
successfully
explored
a
one-pot
strategy
to
synthesize
valuable
chiral
2-functionalized
tetrahydroquinoline
motifs
through
the
precise
modification
of
amides
derived
from
commercially
available
natural
amino
acids.
Angewandte Chemie,
Год журнала:
2023,
Номер
135(49)
Опубликована: Окт. 18, 2023
Abstract
γ‐methylene
C(sp
3
)−H
functionalization
of
linear
free
carboxylic
acids
remains
a
significant
challenge.
Here
in
we
report
Pd(II)‐catalyzed
tandem
γ‐arylation
and
γ‐lactonization
aliphatic
enabled
by
L,X‐type
CarboxPyridone
ligand.
A
wide
range
γ‐arylated
γ‐lactones
are
synthesized
single
step
from
moderate
to
good
yield.
Arylated
lactones
can
readily
be
converted
into
disubstituted
tetrahydrofurans,
prominent
scaffold
amongst
bioactive
molecules.
