The neuroimmune connectome in health and disease

Nature, Год журнала: 2025, Номер 638(8050), С. 333 - 342

Опубликована: Фев. 12, 2025

Язык: Английский

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The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3819 - 3819

Опубликована: Март 29, 2024

Microglial cells, the immune cells of central nervous system, are key elements regulating brain development and health. These fully responsive to stressors, microenvironmental alterations actively involved in construction neural circuits children ability undergo full experience-dependent plasticity adults. Since neuroinflammation is a known element pathogenesis COVID-19, one might expect dysregulation microglial function severely impact both functional structural plasticity, leading cognitive sequelae that appear Long COVID. Therefore, understanding this complex scenario mandatory for establishing possible molecular mechanisms related these symptoms. In present review, we will discuss COVID its association with reduced levels BDNF, altered crosstalk between circulating microglia, increased inflammasomes, cytokines chemokines, as well signaling pathways synaptic remodeling such fractalkines, complement expression SIRPα CD47 molecules matrix remodeling. Together, may help us understand consequences impacting learning disabilities, neurodevelopmental disorders, decline

Язык: Английский

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Immune control of brain physiology

Nature reviews. Immunology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Enteric neurons and immune cells shape anti-helminth immunity

Trends in Parasitology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Psychedelic control of neuroimmune interactions governing fear

Nature, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

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Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain‐spleen interactions. Oxytocin (OT), neuropeptide critical for regulation, upregulated during CSS, though its underlying mechanisms remain unclear. This study investigates the role of OT in splenic modulation using murine model CSS. Behavioral evaluations, serum oxytocin quantification, immunophenotypic analysis were performed. Splenic denervation confirmed OT’s neuromodulatory role, whereas OTR antagonism revealed endocrine function. CSS‐induced elevation was associated with immunosuppression, characterized by increased Foxp3⁺ regulatory T cells reduced CD4⁺ CD19⁺ B cells. also modulated macrophage polarization, inhibiting M1‐like (pro‐inflammatory) enhancing M2‐like (anti‐inflammatory) phenotypes. Denervation or pharmacological blockade signaling partly reversed immunosuppression but adversely affected survival CSS‐exposed mice. Additionally, mice's response to defeat, as shown decreased avoidance behavior. These findings suggest OT‐mediated likely represents compensatory mechanism chronic stress. Targeting OT–immune axis could offer innovative therapeutic approaches stress‐associated disorders restoring homeostasis while maintaining behavioral integrity.

Язык: Английский

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First responders have it covered

Science, Год журнала: 2024, Номер 386(6721), С. 497 - 498

Опубликована: Окт. 31, 2024

Meningeal innate lymphoid cells guide inhibitory neurons in early life.

Язык: Английский

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Innate immune control of synapse development

Nature reviews. Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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Innate lymphoid cell control of neuronal synapse development

Nature reviews. Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

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