Nature reviews. Immunology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Язык: Английский
Nature, Год журнала: 2025, Номер 638(8050), С. 333 - 342
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3819 - 3819
Опубликована: Март 29, 2024
Microglial cells, the immune cells of central nervous system, are key elements regulating brain development and health. These fully responsive to stressors, microenvironmental alterations actively involved in construction neural circuits children ability undergo full experience-dependent plasticity adults. Since neuroinflammation is a known element pathogenesis COVID-19, one might expect dysregulation microglial function severely impact both functional structural plasticity, leading cognitive sequelae that appear Long COVID. Therefore, understanding this complex scenario mandatory for establishing possible molecular mechanisms related these symptoms. In present review, we will discuss COVID its association with reduced levels BDNF, altered crosstalk between circulating microglia, increased inflammasomes, cytokines chemokines, as well signaling pathways synaptic remodeling such fractalkines, complement expression SIRPα CD47 molecules matrix remodeling. Together, may help us understand consequences impacting learning disabilities, neurodevelopmental disorders, decline
Язык: Английский
Процитировано
10
Nature, Год журнала: 2025, Номер unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
2
Neuron, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Nature reviews. Immunology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0
Trends in Parasitology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Abstract Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain‐spleen interactions. Oxytocin (OT), neuropeptide critical for regulation, upregulated during CSS, though its underlying mechanisms remain unclear. This study investigates the role of OT in splenic modulation using murine model CSS. Behavioral evaluations, serum oxytocin quantification, immunophenotypic analysis were performed. Splenic denervation confirmed OT’s neuromodulatory role, whereas OTR antagonism revealed endocrine function. CSS‐induced elevation was associated with immunosuppression, characterized by increased Foxp3⁺ regulatory T cells reduced CD4⁺ CD19⁺ B cells. also modulated macrophage polarization, inhibiting M1‐like (pro‐inflammatory) enhancing M2‐like (anti‐inflammatory) phenotypes. Denervation or pharmacological blockade signaling partly reversed immunosuppression but adversely affected survival CSS‐exposed mice. Additionally, mice's response to defeat, as shown decreased avoidance behavior. These findings suggest OT‐mediated likely represents compensatory mechanism chronic stress. Targeting OT–immune axis could offer innovative therapeutic approaches stress‐associated disorders restoring homeostasis while maintaining behavioral integrity.
Язык: Английский
Процитировано
0
Immunology, Год журнала: 2025, Номер unknown
Опубликована: Май 4, 2025
ABSTRACT Bronchopulmonary dysplasia (BPD) is a severe lung disease affecting preterm infants. The incidence rate in infants aged < 25 weeks > 70% and it causes irreversible damage. BPD high‐risk factor for respiratory system infections adults allergic diseases, such as asthma, which cause heavy burden on society families. Pathological features of include pulmonary inflammation disorders alveolar vascular development, lead to insufficient ventilation. group 2 innate lymphoid cells (ILC2) are recruited the lungs during critical window period development regulate partly by secreting interleukin (IL)‐5 IL‐13; however, specific mechanism remains unclear. In this review, we summarise stage pathophysiological characteristics BPD, role ILC2 its provide evidence supporting key immune cell has potential therapy.
Язык: Английский
Процитировано
0
Science Immunology, Год журнала: 2025, Номер 10(107)
Опубликована: Май 16, 2025
Interactions between the nervous and immune systems are critical to healthy physiology altered in many human diseases. Many of major players type 2 responses, including lymphocytes cytokines, mast cells, immunoglobulin E, have been implicated neuronal function behavior. Conversely, neurons both central peripheral can affect responses behaviors relevant allergy, such as food avoidance. Defining this complex circuitry its molecular intermediates may reveal immunomodulators that be harnessed for therapeutic benefit neurologic diseases Alzheimer’s disease, brain injury, neurodevelopmental disorders. modulation system an important adjunct treating immunologic disorders atopic dermatitis, asthma, allergy. This Review covers recent work defining how regulate regulated by responses.
Язык: Английский
Процитировано
0
Current Opinion in Immunology, Год журнала: 2025, Номер 95, С. 102568 - 102568
Опубликована: Июнь 6, 2025
Язык: Английский
Процитировано
0