Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Language: Английский
Nature, Journal Year: 2025, Volume and Issue: 638(8050), P. 333 - 342
Published: Feb. 12, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3819 - 3819
Published: March 29, 2024
Microglial cells, the immune cells of central nervous system, are key elements regulating brain development and health. These fully responsive to stressors, microenvironmental alterations actively involved in construction neural circuits children ability undergo full experience-dependent plasticity adults. Since neuroinflammation is a known element pathogenesis COVID-19, one might expect dysregulation microglial function severely impact both functional structural plasticity, leading cognitive sequelae that appear Long COVID. Therefore, understanding this complex scenario mandatory for establishing possible molecular mechanisms related these symptoms. In present review, we will discuss COVID its association with reduced levels BDNF, altered crosstalk between circulating microglia, increased inflammasomes, cytokines chemokines, as well signaling pathways synaptic remodeling such fractalkines, complement expression SIRPα CD47 molecules matrix remodeling. Together, may help us understand consequences impacting learning disabilities, neurodevelopmental disorders, decline
Language: Английский
Citations
7
Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Language: Английский
Citations
0
Trends in Parasitology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Nature, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 26, 2025
Abstract Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain‐spleen interactions. Oxytocin (OT), neuropeptide critical for regulation, upregulated during CSS, though its underlying mechanisms remain unclear. This study investigates the role of OT in splenic modulation using murine model CSS. Behavioral evaluations, serum oxytocin quantification, immunophenotypic analysis were performed. Splenic denervation confirmed OT’s neuromodulatory role, whereas OTR antagonism revealed endocrine function. CSS‐induced elevation was associated with immunosuppression, characterized by increased Foxp3⁺ regulatory T cells reduced CD4⁺ CD19⁺ B cells. also modulated macrophage polarization, inhibiting M1‐like (pro‐inflammatory) enhancing M2‐like (anti‐inflammatory) phenotypes. Denervation or pharmacological blockade signaling partly reversed immunosuppression but adversely affected survival CSS‐exposed mice. Additionally, mice's response to defeat, as shown decreased avoidance behavior. These findings suggest OT‐mediated likely represents compensatory mechanism chronic stress. Targeting OT–immune axis could offer innovative therapeutic approaches stress‐associated disorders restoring homeostasis while maintaining behavioral integrity.
Language: Английский
Citations
0
Science, Journal Year: 2024, Volume and Issue: 386(6721), P. 497 - 498
Published: Oct. 31, 2024
Meningeal innate lymphoid cells guide inhibitory neurons in early life.
Language: Английский
Citations
0
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Language: Английский
Citations
0
Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Language: Английский
Citations
0