International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(12), С. 1546 - 1546
Опубликована: Ноя. 22, 2024
The
gut
microbiota
plays
a
fundamental
role
in
the
host's
energy
metabolism
and
development
of
metabolic
diseases
such
as
arterial
hypertension,
insulin
resistance,
atherosclerosis.
Our
study
aimed
to
investigate
potential
hypertension
among
individuals
Kazakh
population
without
resistance.
16S
rRNA
gene
sequencing
faecal
samples
from
197
subjects
was
performed.
Preliminary
binary
comparisons
composition
depending
on
presence
resistance
revealed
statistically
significant
differences
abundance
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
Host-associated
microbiota
follow
predictable
assembly
patterns
but
exhibit
significant
variation
at
the
bacterial
isolate
level,
depending
on
host
and
environmental
context.
This
variability
poses
challenges
for
studying,
predicting,
engineering
microbiomes.
Here
we
examined
how
Arabidopsis,
Barley,
Lotus
plants
recruit
specific
bacteria
from
highly
complex
synthetic
communities
(SynComs)
composed
of
hundreds
isolates
originating
these
when
grown
in
natural
soil.
We
discovered
that,
despite
their
taxonomic
diversity,
enriched
by
three
plant
species
encode
largely
overlapping
functions.
A
set
266
functions
common
among
all
host-associated
was
identified
foundation
microbiota's
functional
potential.
Analysis
differences
observed
between
root-associated
revealed
that
recruited
Arabidopsis
Barley
were
primarily
driven
SynCom
composition,
while
selected
fewer
with
more
diverse
functionalities,
akin
to
a
"Swiss
army
knife"
strategy.
analysed
level
found
this
can
be
explained
combined
family
level.
Additionally,
across
major
taxa,
covering
broader
range
family's
diversity
achieved
higher
relative
abundance
root
communities.
Our
work
sheds
light
key
principles
guiding
recruitment
into
microbiota,
offering
valuable
insights
microbiome
inoculant
discovery
previously
inaccessible
Current Psychiatry Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Purpose
of
Review
With
the
growing
body
research
examining
link
between
sleep
disorders,
including
insomnia
and
obstructive
apnea
(OSA),
gut
microbiome,
this
review
seeks
to
offer
a
thorough
overview
most
significant
findings
in
emerging
field.
Recent
Findings
Current
evidence
suggests
complex
association
imbalances
insomnia,
OSA,
with
potential
reciprocal
interactions
that
may
influence
each
other.
Notably,
specific
microbiome
species,
whether
over-
or
under-abundant,
have
been
associated
variation
both
mood
patients
diagnosed
with,
e.g.,
major
depressive
disorder
bipolar
disorder.
Summary
Further
studies
are
needed
explore
targeting
as
therapeutic
approach
for
its
possible
effects
on
mood.
The
variability
current
scientific
literature
highlights
importance
establishing
standardized
methodologies.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
It
is
well
established
that
host
genetics
determine
much
of
hosts
response
to
parasites,
but
recent
research
has
highlighted
the
microbiome
plays
a
role
in
defense
against
parasites.
Interactions
between
resistance
parasites
and
are
widely
acknowledged;
for
example,
can
modulate
immune
response,
vice
versa.
However,
it
remains
unclear
how
system
may
together
influence
host's
overall
In
many
species
males
females
differ
both
their
genetically-based
parasite
composition
structure
associated
microbiomes.
We
therefore
expect
interactions
females,
potentially
explaining
often-observed
variation
To
investigate
interact
shape
we
imposed
truncation
selection
on
Trinidadian
guppies
(Poecilia
reticulata)
specialist
ectoparasite
Gyrodactylus
turnbulli.
The
30%
with
lowest
number
'parasite
load',
during
experimental
infection
founded
resistant
line,
highest
load
susceptible
while
randomly
chosen
uninfected
fish
control
line.
After
3-6
generations
breeding
absence
sampled
skin-associated
from
these
lines
then
infected
them
G.
used
Dirichlet
multinomial
modeling
(DMM)
machine
learning
identify
bacterial
community
types
across
evaluated
importance
line
type
over
time
'infection
severity'.
Among
developed
significantly
lower
severity,
higher
than
any
other
treatment.
males,
however,
severity
lines,
there
was
no
difference
lines.
also
found
female
had
tolerance
compared
or
females.
This
apparent
tradeoff
supported
by
analysis
individual-level
data.
host-associated
microbiomes
explain
as
genetics,
two
factors
appear
independent
additive
effects
severity.
Furthermore,
post-hoc
test
showed
model
including
artificial
better
at
models
either
variable
alone.
Our
results
suggest
an
active
interaction
not
passive
reflection
genetics.
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(12), С. 1546 - 1546
Опубликована: Ноя. 22, 2024
The
gut
microbiota
plays
a
fundamental
role
in
the
host's
energy
metabolism
and
development
of
metabolic
diseases
such
as
arterial
hypertension,
insulin
resistance,
atherosclerosis.
Our
study
aimed
to
investigate
potential
hypertension
among
individuals
Kazakh
population
without
resistance.
16S
rRNA
gene
sequencing
faecal
samples
from
197
subjects
was
performed.
Preliminary
binary
comparisons
composition
depending
on
presence
resistance
revealed
statistically
significant
differences
abundance
