Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Abstract The amygdaloid complex consists of multiple nuclei and is a key node in controlling temporal lobe epilepsy (TLE) both human animal model studies. However, the specific nucleus neural circuitry governing seizures remain unknown. Here, it discovered that activation glutamatergic neurons posterior basolateral amygdala (pBLA) induces severe even mortality. pBLA project collateral connections to brain regions, including insular cortex (IC), bed stria terminalis (BNST), central (CeA). Stimulation pBLA‐targeted IC triggers seizures, whereas ablation suppresses induced by activating neurons. GABAergic BNST CeA establish feedback inhibition on Deleting or leads sporadic highlighting their role balancing activity. Furthermore, receive inputs from ventral hippocampal CA1 (vCA1). Ablation mitigates acute chronic intrahippocampal kainic acid‐induced mouse TLE. Together, these findings identify as pivotal for regulating epileptic

Язык: Английский

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A sensitive period for the development of episodic-like memory in mice

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Framing Knowledge as Conceptual Structure

Advances in analytics for learning and teaching, Год журнала: 2025, Номер unknown, С. 9 - 37

Опубликована: Янв. 1, 2025

Язык: Английский

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Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves

Опубликована: Май 2, 2025

The CA3 region of the hippocampus is major site sharp wave initiation, and a brain crucially involved in learning memory. Highly recurrent connectivity within its excitatory network thought to underlie processes memory formation. Recent work has indicated that distinct subpopulations pyramidal neurons this may contribute differently activity, including waves, CA3. Exactly how these contributions arise not yet known. Here, we disentangle local between two cell types: thorny athorny cells. We find an asymmetry populations, with cells receiving strong input from both Conversely, population receives very little population. Computational modeling suggests scheme determine sequential activation types during large events such as waves.

Язык: Английский

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Dynamic memory enqrams: Unveiling the celular mechanisms of memory encoding, consolidation, generalizaton, and updating in the brain

Brain medicine :, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Май 20, 2025

One of the fundamental questions neuroscience is how brain can store, generalize, and update memories. Memories are believed to be stored through biophysical molecular changes in neuronal ensembles called engrams, which distributed across different regions. The dynamic that occur engram cells during encoding, consolidation, generalization, updating memory still not fully understood. However, recent advancements techniques for labeling manipulating neural activity have allowed investigation engrams processes. Understanding dynamics may inform interventions posttraumatic stress disorder disorders. In this review, we summarize progress updating, shedding new light on mechanisms underlying formation maturation.

Язык: Английский

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A sensitive period for the development of episodic-like memory in mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Episodic-like memory is a later-developing cognitive function supported by the hippocampus. In mice, formation of extracellular perineuronal nets in subfield CA1 dorsal hippocampus controls emergence episodic-like during fourth postnatal week (Ramsaran et al., 2023). Whether timing onset hard-wired, or flexibly set early-life experiences critical sensitive period for hippocampal maturation, unknown. Here, we show that trajectories development vary mice given different sets spanning second and third weeks. Specifically, precision developed later experienced adversity, while it earlier enrichment. Moreover, demonstrate modulating pace net CA1. These results indicate undergoes which determine development.

Язык: Английский

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2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 26, 2024

Neural circuits are characterized by genetically and functionally diverse cell types. A mechanistic understanding of circuit function is predicated on linking the genetic physiological properties individual neurons. However, it remains highly challenging to map transcriptional heterogeneous neuronal subtypes in mammalian cortical

Язык: Английский

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