bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 26, 2024
Neural circuits are characterized by genetically and functionally diverse cell types. A mechanistic understanding of circuit function is predicated on linking the genetic physiological properties individual neurons. However, it remains highly challenging to map transcriptional heterogeneous neuronal subtypes in mammalian cortical
Language: Английский
Current Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Published: May 2, 2025
The CA3 region of the hippocampus is major site sharp wave initiation, and a brain crucially involved in learning memory. Highly recurrent connectivity within its excitatory network thought to underlie processes memory formation. Recent work has indicated that distinct subpopulations pyramidal neurons this may contribute differently activity, including waves, CA3. Exactly how these contributions arise not yet known. Here, we disentangle local between two cell types: thorny athorny cells. We find an asymmetry populations, with cells receiving strong input from both Conversely, population receives very little population. Computational modeling suggests scheme determine sequential activation types during large events such as waves.
Language: Английский
Citations
0
Advances in analytics for learning and teaching, Journal Year: 2025, Volume and Issue: unknown, P. 9 - 37
Published: Jan. 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Episodic-like memory is a later-developing cognitive function supported by the hippocampus. In mice, formation of extracellular perineuronal nets in subfield CA1 dorsal hippocampus controls emergence episodic-like during fourth postnatal week (Ramsaran et al., 2023). Whether timing onset hard-wired, or flexibly set early-life experiences critical sensitive period for hippocampal maturation, unknown. Here, we show that trajectories development vary mice given different sets spanning second and third weeks. Specifically, precision developed later experienced adversity, while it earlier enrichment. Moreover, demonstrate modulating pace net CA1. These results indicate undergoes which determine development.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 30, 2024
Abstract The amygdaloid complex consists of multiple nuclei and is a key node in controlling temporal lobe epilepsy (TLE) both human animal model studies. However, the specific nucleus neural circuitry governing seizures remain unknown. Here, it discovered that activation glutamatergic neurons posterior basolateral amygdala (pBLA) induces severe even mortality. pBLA project collateral connections to brain regions, including insular cortex (IC), bed stria terminalis (BNST), central (CeA). Stimulation pBLA‐targeted IC triggers seizures, whereas ablation suppresses induced by activating neurons. GABAergic BNST CeA establish feedback inhibition on Deleting or leads sporadic highlighting their role balancing activity. Furthermore, receive inputs from ventral hippocampal CA1 (vCA1). Ablation mitigates acute chronic intrahippocampal kainic acid‐induced mouse TLE. Together, these findings identify as pivotal for regulating epileptic
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 26, 2024
Neural circuits are characterized by genetically and functionally diverse cell types. A mechanistic understanding of circuit function is predicated on linking the genetic physiological properties individual neurons. However, it remains highly challenging to map transcriptional heterogeneous neuronal subtypes in mammalian cortical
Language: Английский
Citations
0