The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Язык: Английский

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Immunosenescence promotes cancer development: from mechanisms to treatment strategies

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 10, 2025

The body's innate immune system plays a pivotal role in identifying and eliminating cancer cells. However, as the ages, its functionality can deteriorate, becoming dysfunctional, inefficient, or even inactive—a condition referred to immunosenescence. This decline significantly increases risk of malignancies. While pro-cancer effects T-cell aging have been widely explored, there remains notable gap literature regarding impact on cells, such macrophages neutrophils. review seeks address this gap, with emphasis these cell types. Furthermore, although certain immunotherapies, including checkpoint inhibitors (ICIs), demonstrated efficacy across broad spectrum cancers, elderly patients are less likely derive clinical benefit from treatments. In some cases, they may experience immune-related adverse events (irAEs). senolytic strategies shown promise exerting anti-cancer effects, their reactions potential off-target present significant challenges. aims elucidate immunosenescence, implications for safety ICIs, anti-aging treatment strategies. addition, optimizing therapies minimize enhance therapeutic outcomes critical focus future research endeavors. Senescence is an inevitable phenomenon human body, scientists explored specific mechanisms by which immunosenescence advances development cancer. summarizes characteristics be used level surveillance cancers due "Targeting immunosenescence" new idea strategy therapy.

Язык: Английский

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Tumor-Infiltrating Clonal Hematopoiesis

New England Journal of Medicine, Год журнала: 2025, Номер 392(16), С. 1594 - 1608

Опубликована: Апрель 23, 2025

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients cancer. CHIP mutations high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal (TI-CH). The frequency TI-CH and its effect on tumor evolution are unclear. We characterized 421 early-stage non-small-cell lung cancer (NSCLC) from the TRACERx study 49,351 MSK-IMPACT pan-cancer cohort. studied association survival disease recurrence evaluated functional TET2-mutant biologic features tumors. Among NSCLC, 42% those had TI-CH. independently predicted risk death or recurrence, adjusted hazard ratio 1.80 (95% confidence interval [CI], 1.23 to 2.63) as compared absence 1.62 CI, 1.02 2.56) solid 26% conferred any cause that was 1.17 times 1.06 1.29) TET2 were strongest genetic predictor TI-CH; such enhanced monocyte migration cells, fueled myeloid-rich microenvironment mice, resulted promotion organoid growth. NSCLC remodeled immune accelerated growth, findings support role for aging-related hematologic proliferation evolution. (Funded by Royal Society others.).

Язык: Английский

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Embracing diversity: macrophage complexity in cancer

Trends in cancer, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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CXCL12 ameliorates neutrophilia and disease severity in SARS-CoV-2 infection

Journal of Clinical Investigation, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Neutrophils, particularly low-density neutrophils (LDNs), are believed to contribute acute COVID-19 severity. Here, we showed that neutrophilia can be detected acutely and even months after SARS-CoV-2 infection in patients mice, while neutrophil depletion reduced disease severity mice. A key factor severe infected mice was traced the chemokine CXCL12 secreted by bone marrow cells unexpectedly, endothelial cells. levels were negatively correlated with LDN numbers longitudinal analyses of patient blood samples. blockade SARS-CoV-2-infected increased blood/lung thereby accelerating progression without changing lung virus titers. The exaggerated mortality caused reversed depletion. In addition, blocking interactions between Angiotensin-Converting Enzyme 2 (ACE2) levels, suggesting a signal transduction from virus-mediated ACE2 ligation secretion. Collectively, these results demonstrate previously unappreciated role diminishing neutrophilia, including low density its deleterious effects infections. also support involvement SARS-CoV-2-endothelial cell viral pathogenesis.

Язык: Английский

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Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes

Cell Reports Medicine, Год журнала: 2025, Номер unknown, С. 101989 - 101989

Опубликована: Март 1, 2025

Clonal hematopoiesis (CH)-the expansion of somatically mutated hematopoietic cells-is common in solid cancers. CH is associated with systemic inflammation, but its impact on tumor biology underexplored. Here, we report the effects microenvironment (TME) using 1,550 treatment-naive patient samples from Clinical Proteomics Tumor Analysis Consortium (CPTAC) cohort. present 18.3% patients, one-third mutations also detectable tumor-derived DNA same individual (CH-Tum), reflecting CH-mutant leukocyte infiltration. Across cancers, presence CH-Tum worse survival outcomes. Molecular analyses reveal an association between and immune-rich, inflammatory TME that notably distinct age-related gene expression changes. These are most prominent glioblastoma, where correlates pronounced macrophage infiltration, aggressive, mesenchymal phenotype. Our findings demonstrate shapes TME, potential applications as a biomarker precision oncology.

Язык: Английский

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Harnessing myeloid cells in cancer

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Март 6, 2025

Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.

Язык: Английский

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Ceria Centre to Enhance Multi‐Active and Photothermal Response Janus Patch for Chronic Wound Senescence Inhibition and Repair

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Bacterial infections and complex microenvironments induce cellular oxidative stress senescence severely affect chronic wound healing. However, the antibacterial effect of most dressings is single, which only against wound-breeding bacteria but cannot resist further invasion in environment into wound. Few can simultaneously fulfill antibacterial, antifouling, regulation, protection. Therefore, a Janus patch (SBMA/OHA/GelMA/TA-CeO2@HA (HGT-C@HA)) prepared, top superhydrophilic SBMA zwitterionic layer resists bacterial adhesion, CeO2 coated with hyaluronic acid (HA) loaded bottom gel as functional center. After immersion tannic (TA), Ce-TA chelate formation situ confers photothermal antimicrobial properties to hydrogel. It validated that HA-coated enable dressing obtain higher antioxidant by regulating proportion Ce3+ on nanoparticle surface, protects cells from high glucose H2O2 effectively inhibits intracellular DNA damage mitigate senescence. In vivo experiments illustrate material significantly accelerated healing improved quality healing, demonstrating significant potential this diabetic

Язык: Английский

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Turning cold into hot: emerging strategies to fire up the tumor microenvironment

Trends in cancer, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Neoadjuvant immune checkpoint therapy: Enabling insights into fundamental human immunology and clinical benefit

Cancer Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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