Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 7, 2025
Abstract
The
mucosal
immune
system,
as
the
most
extensive
peripheral
network,
serves
frontline
defense
against
a
myriad
of
microbial
and
dietary
antigens.
It
is
crucial
in
preventing
pathogen
invasion
establishing
tolerance.
A
comprehensive
understanding
immunity
essential
for
developing
treatments
that
can
effectively
target
diseases
at
their
entry
points,
thereby
minimizing
overall
impact
on
body.
Despite
its
importance,
our
knowledge
remains
incomplete,
necessitating
further
research.
outbreak
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
underscored
critical
role
disease
prevention
treatment.
This
systematic
review
focuses
dynamic
interactions
between
mucosa-associated
lymphoid
structures
related
diseases.
We
delve
into
basic
functions
these
tissues
during
processes
explore
intricate
regulatory
networks
mechanisms
involved.
Additionally,
we
summarize
novel
therapies
clinical
research
advances
immunity-related
also
addresses
challenges
vaccines,
which
aim
to
induce
specific
responses
while
maintaining
tolerance
non-pathogenic
microbes.
Innovative
therapies,
such
nanoparticle
vaccines
inhalable
antibodies,
show
promise
enhancing
offer
potential
improved
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(3)
Опубликована: Янв. 9, 2024
The
emergence
of
Omicron
lineages
and
descendent
subvariants
continues
to
present
a
severe
threat
the
effectiveness
vaccines
therapeutic
antibodies.
We
have
previously
suggested
that
an
insufficient
mucosal
immunoglobulin
A
(IgA)
response
induced
by
mRNA
is
associated
with
surge
in
breakthrough
infections.
Here,
we
further
show
intramuscular
and/or
inactivated
cannot
sufficiently
boost
secretory
IgA
uninfected
individuals,
particularly
against
variant.
thus
engineered
characterized
recombinant
monomeric,
dimeric,
IgA1
antibodies
derived
from
four
neutralizing
IgG
monoclonal
(mAbs
01A05,
rmAb23,
DXP-604,
XG014)
targeting
receptor-binding
domain
spike
protein.
Compared
their
parental
antibodies,
dimeric
showed
higher
activity
different
variants
concern
(VOCs),
part
due
increased
avidity.
Importantly,
or
form
DXP-604
antibody
significantly
outperformed
its
antibody,
neutralized
BA.1,
BA.2,
BA.4/5
25-
75-fold
increase
potency.
In
human
angiotensin
converting
enzyme
2
(ACE2)
transgenic
mice,
single
intranasal
dose
conferred
prophylactic
protection
BA.5.
Thus,
delivered
nasal
administration
may
potentially
be
exploited
for
treatment
prevention
infection,
thereby
providing
alternative
tool
combating
immune
evasion
current
circulating
and,
potentially,
future
VOCs.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
The
emergence
of
monkeypox
has
become
a
global
health
threat
after
the
COVID-19
pandemic.
Due
to
lack
available
specifically
treatment
against
MPV,
developing
an
vaccine
is
thus
most
prospective
and
urgent
strategy.
Herein,
programmable
macrophage
vesicle
based
bionic
self-adjuvanting
(AM@AEvs-PB)
first
developed
for
defending
virus
(MPV).
Based
on
MPV-related
antigen-stimulated
macrophage-derived
vesicles,
nanovaccine
constructed
by
loading
mature
virion
(MV)-related
intracellular
protein
(A29L/M1R)
simultaneously
modifying
with
enveloped
(EV)
antigen
(B6R),
enabling
them
effectively
promote
presentation
enhance
adaptive
immune
through
self-adjuvant
Owing
synergistic
properties
coloaded
MV
EV
in
defensing
activation
ratio
antigen-presenting
cells
nearly
four
times
than
that
single
same
dose,
resulting
stronger
immunity
host.
Notably,
intramuscular
injection
uptake
AM@AEvs-PB
demonstrated
vigorous
immune-protective
effects
mouse
challenge
attempt,
offering
promising
strategy
pre-clinical
development.
Cell,
Год журнала:
2024,
Номер
187(9), С. 2079 - 2094
Опубликована: Апрель 1, 2024
Several
conceptual
pillars
form
the
foundation
of
modern
immunology,
including
clonal
selection
theory,
antigen
receptor
diversity,
immune
memory,
and
innate
control
adaptive
immunity.
However,
some
immunological
phenomena
cannot
be
explained
by
current
framework.
Thus,
we
still
do
not
know
how
to
design
vaccines
that
would
provide
long-lasting
protective
immunity
against
certain
pathogens,
why
autoimmune
responses
target
antigens
others,
or
response
infection
sometimes
does
more
harm
than
good.
Understanding
these
mysteries
may
require
question
existing
assumptions
develop
test
alternative
explanations.
Immunology
is
increasingly
at
a
point
when,
once
again,
exploring
new
perspectives
becomes
necessity.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 7, 2025
Abstract
The
mucosal
immune
system,
as
the
most
extensive
peripheral
network,
serves
frontline
defense
against
a
myriad
of
microbial
and
dietary
antigens.
It
is
crucial
in
preventing
pathogen
invasion
establishing
tolerance.
A
comprehensive
understanding
immunity
essential
for
developing
treatments
that
can
effectively
target
diseases
at
their
entry
points,
thereby
minimizing
overall
impact
on
body.
Despite
its
importance,
our
knowledge
remains
incomplete,
necessitating
further
research.
outbreak
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
underscored
critical
role
disease
prevention
treatment.
This
systematic
review
focuses
dynamic
interactions
between
mucosa-associated
lymphoid
structures
related
diseases.
We
delve
into
basic
functions
these
tissues
during
processes
explore
intricate
regulatory
networks
mechanisms
involved.
Additionally,
we
summarize
novel
therapies
clinical
research
advances
immunity-related
also
addresses
challenges
vaccines,
which
aim
to
induce
specific
responses
while
maintaining
tolerance
non-pathogenic
microbes.
Innovative
therapies,
such
nanoparticle
vaccines
inhalable
antibodies,
show
promise
enhancing
offer
potential
improved
