A Human‐Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 11, 2024

Abstract Magnetic navigation systems are used to precisely manipulate magnetically responsive materials enabling the realization of new minimally invasive procedures using magnetic medical devices. Their widespread applicability has been constrained by high infrastructure demands and costs. The study reports on a portable electromagnetic system, Navion, which is capable generating large field over workspace. system easy install in hospital operating rooms transportable through health care facilities, aiding adoption First, design implementation approach for introduced its performance characterized. Next, vitro different microrobot structures demonstrated gradients rotating fields. Spherical permanent magnets, electroplated cylindrical microrobots, microparticle swarms, composite bacteria‐inspired helical investigated. catheters also two challenging endovascular tasks: 1) an angiography procedure 2) deep within circle Willis. Catheter porcine model vivo perform under guidance.

Язык: Английский

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Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting

The Innovation, Год журнала: 2025, Номер 6(2), С. 100777 - 100777

Опубликована: Янв. 18, 2025

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% 2% [w/w]) was encapsulated in by an imide bond. could imitate the mode of school wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) adapt changing complex physiological environment through 3D MMP system. overcame blood flow resistance biological barriers optimized driving properties according vivo imaging (magnetic resonance fluorescence) histopathology. The performance fabricated verified cells tumor-bearing mouse models. showed high efficiency drug delivery targeting at tumor site (>10-fold), lower toxicity than free doxorubicin (5 mg/kg body weight), activated immune response site, significantly lengthened survival for mice. synergistic interaction between underscores immense potential this system, indicating revolution field chemotherapy.

Язык: Английский

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Multi-Section Magnetic Soft Robot with Multirobot Navigation System for Vasculature Intervention

Cyborg and Bionic Systems, Год журнала: 2024, Номер 5

Опубликована: Янв. 1, 2024

Magnetic soft robots have recently become a promising technology that has been applied to minimally invasive cardiovascular surgery. This paper presents the analytical modeling of novel multi-section magnetic robot (MS-MSR) with multi-curvature bending, which is maneuvered by an associated collaborative multirobot navigation system (CMNS) actuation and ultrasound guidance targeted for intravascular intervention. The kinematic dynamic analysis MS-MSR’s telescopic motion performed using optimized Cosserat rod model considering effect external heterogeneous field, generated mobile manipulator adapt complex steering scenarios. Meanwhile, extracorporeal exploited track robot’s distal tip realize closed-loop control. We also conduct quadratic programming-based optimization scheme synchronize multi-objective task-space CMNS null-space projection. It allows formulation comprehensive controller priority collaboration. Experimental results demonstrate proposed can be successfully navigated within multi-bifurcation environment shape error 3.62 ± 1.28 ∘ 1.08 0.45 mm under through in vitro ultrasound-guided vasculature interventional tests.

Язык: Английский

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Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Язык: Английский

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Teleoperated Magnetic Endoscopy: A Case Study and Perspective

Advanced Intelligent Systems, Год журнала: 2024, Номер unknown

Опубликована: Авг. 18, 2024

Teleoperated robotic surgery is a rapidly growing field that promises to overcome geographical barriers and share expertise over long distances for variety of minimally invasive procedures. A particularly promising technology teleoperation magnetic navigation. In contrast conventional surgical robots, navigation system generates external fields safely dexterously steer soft devices within the human body, enabling versatile, economical, accessible telesurgery platform This perspective highlights recent research efforts in platforms their translation clinical settings context endoscopic discussion supported by case study performed at Multi‐Scale Medical Robotics Center Hong Kong, where an vivo gastroscopy porcine model tandem with two operators, alternating between clinician controlling procedure from operating room Kong remote expert operator console Zurich. The achievements challenges this highlight capabilities future potential telesurgery.

Язык: Английский

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Telesurgery and the importance of context

Science Robotics, Год журнала: 2025, Номер 10(99)

Опубликована: Фев. 26, 2025

Telesurgery has the potential to overcome geographical barriers in surgical care, encouraging its deployment areas with sparse expertise. Despite successful in-human experiments and substantial technological progress, adoption of telesurgery remains slow. In this Review, we analyze reasons for slow adoption. First, identify various contexts highlight vastly different requirements their realization. We then discuss why procedures high urgency skill sparsity are particularly suitable telesurgery. Last, summarize key research essential further progress. The goal Review is provide reader a comprehensive analysis current state guidance faster exciting technology.

Язык: Английский

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Robotics in Neurointervention

Опубликована: Янв. 1, 2025

Язык: Английский

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Permanent magnets in magnetic medicine: applications and advances

Опубликована: Май 1, 2025

Язык: Английский

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Nanozyme‐Shelled Microcapsules for Targeting Biofilm Infections in Confined Spaces

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Bacterial infections in irregular and branched confinements pose significant therapeutic challenges. Despite their high antimicrobial efficacy, enzyme‐mimicking nanoparticles (nanozymes) face difficulties achieving localized catalysis at distant infection sites within confined spaces. Incorporating nanozymes into microrobots enables the delivery of catalytic agents to hard‐to‐reach areas, but poor nanoparticle dispersibility distribution during fabrication hinder performance. To address these challenges, a nanozyme‐shelled microrobotic platform is introduced using magnetic microcapsules with collective adaptive mobility for automated navigation complex confinements. Using double emulsions produced from microfluidics as templates, iron oxide silica are assembled 100‐µm microcapsules, which self‐organize multi‐unit, millimeter‐size assemblies under rotating fields. These exhibit peroxidase‐like activity, efficiently catalyzing hydrogen peroxide generate reactive oxygen species (ROS). Notably, microcapsule display remarkable arched confinements, reaching targeted apical regions tooth canal accuracy. Furthermore, perform rapid situ effectively kill biofilms on contact via ROS generation, enabling antibiofilm action. This study demonstrates facile method integrating onto versatile current needs microenvironments.

Язык: Английский

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A novel endotracheal intubation method based on magnetic-guided technology

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 20, 2024

BACKGROUND Endotracheal intubation (ETI) is a crucial skill for airway management in anesthesia and emergency. The classic ETI based on laryngoscopy have limitations learning curve, respiratory exposure risk difficult airway. Magnetic-guided technique was the non-contact force has been successfully used laparoscopy endoscopy to simplify operation improve effectiveness. Therefore, we introduce magnetic-guided device of first time, developing method. METHODS consisted magnetic guidewire an external magnet (EM). For novel device, control parameter (working distance) determined by anatomic parameters. former investigated test bench, later measured through CT graph. Then 30 undergraduates without prior training divided into medical non-medical group according participant’s major. Both subgroups underwent with methods. also be tested module. first-attempt success rate, total time 5-point Likert scale difficulty were recorded assessments. RESULTS We obtained tip deflection angle-distance curves device. In addition, surface distance 32.45 ± 5.24mm, angle 35.4 7.6°. Thus, working 40–60 mm. completed close direct patient’s oral cavity. Compared method, it got higher rate (magnetic-guided vs classic: 80.0% vs. 66.7%, p<0.05) less 42.5 2.7s 49.4 5.7s, p<0.01) normal most subjects indicated easier than This more evident Non-medical Group 2.8 0.8 3.3 0.7, p<0.01). Even airway, method still 73.3% 53.3%, 45.3 3.7s 53.4 3.5s, CONCLUSION simple, safe effective work, friendlier persons It avoids during operation. use can enhance safety efficiency management, making tool rapidly perform ETI.

Язык: Английский

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