Exploration of Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Aim:
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disorder
marked
by
overgrowth
of
joint
tissue
and
inflammation
the
synovium.
The
mammalian
target
rapamycin
(mTOR),
functioning
as
a
serine/threonine
protein
kinase,
recognized
for
its
role
in
controlling
cell
proliferation,
metabolism,
inflammatory
responses.
While
there
some
evidence
hinting
at
link
between
RA
proteins
downstream
mTOR,
findings
are
not
definitive.
In
light
this,
we
have
undertaken
Mendelian
randomization
(MR)
analysis
to
investigate
potential
connection
mTOR
RA.
Cancer Immunology Immunotherapy,
Год журнала:
2025,
Номер
74(6)
Опубликована: Апрель 29, 2025
Allogeneic
stem
cell
transplant
and
immunosuppressive
therapy
(IST)
are
the
current
standard
treatments
for
patients
with
aplastic
anemia
(AA).
However,
IST
also
carries
significant
risks
side
effects,
up
to
30-50%
of
experienced
refractory
or
relapsed
disease
following
IST.
Treating
AA
remains
challenging
novel
efficient
therapies
in
critical
need.
The
IL-2
inducible
T-cell
kinase
(ITK)
plays
a
crucial
role
T
response
functions
as
regulator
activity.
While
ITK
inhibition
has
shown
promise
various
immune-related
disorders,
its
potential
pathophysiology
not
been
thoroughly
investigated.
We
observed
elevated
level
phosphorylated
cells
from
mouse
models.
Moreover,
we
found
that
both
treatment
an
inhibitor
conditional
depletion
Itk
donor
mice
alleviated
bone
marrow
hypoplasia,
improved
cytopenia,
extended
survival
rates.
Notably,
orchestrates
quantity
function
by
reducing
infiltration
suppressing
secretion
key
inflammatory
cytokines
mice.
Our
data
suggest
could
potentially
offer
new
therapeutic
strategy
AA.
Cell Reports,
Год журнала:
2024,
Номер
43(9), С. 114681 - 114681
Опубликована: Авг. 24, 2024
Regulatory
T
cells
(Tregs)
suppress
pro-inflammatory
conventional
cell
(Tconv)
responses.
As
lipids
impact
signaling
and
function,
we
compare
the
lipid
composition
of
CD4
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2250 - 2250
Опубликована: Окт. 3, 2024
T-cell-based
adoptive
cell
therapies
have
emerged
at
the
forefront
of
cancer
immunotherapies;
however,
failed
long-term
survival
and
inevitable
exhaustion
transplanted
T
lymphocytes
in
vivo
limits
clinical
efficacy.
Leukemia
blasts
possess
enhanced
glycolysis
(Warburg
effect),
exploiting
their
microenvironment
to
deprive
nutrients
(e.g.,
glucose)
from
cells,
leading
T-cell
dysfunction
leukemia
progression.
Medicine,
Год журнала:
2024,
Номер
103(41), С. e40024 - e40024
Опубликована: Окт. 11, 2024
According
to
the
findings
of
multiple
observational
studies,
immune
disorder
was
a
risk
factor
for
prostatitis.
However,
it
remained
unknown
whether
there
direct
causal
relationship
between
cells
and
prostatitis
or
this
mediated
by
plasma
metabolites.
Based
on
pooled
data
genome-wide
association
study
(GWAS),
genetic
variant
used
predict
effects
731
immunophenotypes
determine
were
1400
The
bidirectional
2-sample
Mendelian
randomization
(MR)
method
adopted
uncover
Subsequently,
2-step
MR
employed
evaluate
metabolites
quantify
mediating
corresponding
ratios.
In
addition,
Bayesian-weighted
(BWMR)
verify
results.
Among
analyzed,
16
had
relationships
with
prostatitis,
including
11
positive
correlations
(
P
<
.05,
beta
>
0)
5
negative
0).
analysis
screened
out
9
related
X
−
24344
levels
CD3
CD39
+
activated
Treg
(mediation
effect:
0.01;
ratio:
9.82%).
Both
histidine
betaine
(hercynine)
proline-to-glutamate
ratio
CD14
–
CD16
monocyte
absolute
count
mediation
−0.016
(14.20%)
−0.008
(7.24%),
respectively.
glutamine
degradant
HLA
DR
CD4
%T
effect
−0.012,
accounting
8.07%
total.
present
indicated
that
cell
subsets
predicted
based
gene
expression
profiles
potentially
beneficial
harmful
factors
may
serve
as
relationship.
thus
shed
light
deciphering
immunologic
mechanism
