ACS Sensors,
Год журнала:
2020,
Номер
5(11), С. 3346 - 3364
Опубликована: Ноя. 13, 2020
Chemometrics
play
a
critical
role
in
biosensors-based
detection,
analysis,
and
diagnosis.
Nowadays,
as
branch
of
artificial
intelligence
(AI),
machine
learning
(ML)
have
achieved
impressive
advances.
However,
novel
advanced
ML
methods,
especially
deep
learning,
which
is
famous
for
image
facial
recognition,
speech
has
remained
relatively
elusive
to
the
biosensor
community.
Herein,
how
can
be
beneficial
biosensors
systematically
discussed.
The
advantages
drawbacks
most
popular
algorithms
are
summarized
on
basis
sensing
data
analysis.
Specially,
methods
such
convolutional
neural
network
(CNN)
recurrent
(RNN)
emphasized.
Diverse
ML-assisted
electrochemical
biosensors,
wearable
electronics,
SERS
other
spectra-based
fluorescence
colorimetric
comprehensively
Furthermore,
networks
multibiosensor
fusion
introduced.
This
review
will
nicely
bridge
with
greatly
expand
chemometrics
ACS Nano,
Год журнала:
2017,
Номер
11(10), С. 9614 - 9635
Опубликована: Сен. 13, 2017
Skin
is
the
largest
organ
of
human
body,
and
it
offers
a
diagnostic
interface
rich
with
vital
biological
signals
from
inner
organs,
blood
vessels,
muscles,
dermis/epidermis.
Soft,
flexible,
stretchable
electronic
devices
provide
novel
platform
to
soft
tissues
for
robotic
feedback
control,
regenerative
medicine,
continuous
health
monitoring.
Here,
we
introduce
term
"lab-on-skin"
describe
set
that
have
physical
properties,
such
as
thickness,
thermal
mass,
elastic
modulus,
water-vapor
permeability,
which
resemble
those
skin.
These
can
conformally
laminate
on
epidermis
mitigate
motion
artifacts
mismatches
in
mechanical
properties
created
by
conventional,
rigid
electronics
while
simultaneously
providing
accurate,
non-invasive,
long-term,
Recent
progress
design
fabrication
sensors
more
advanced
capabilities
enhanced
reliability
suggest
an
impending
translation
these
research
lab
clinical
environments.
Regarding
advances,
first
part
this
manuscript
reviews
materials,
strategies,
powering
systems
used
electronics.
Next,
paper
provides
overview
applications
cardiology,
dermatology,
electrophysiology,
sweat
diagnostics,
emphasis
how
may
replace
conventional
tools.
The
review
concludes
outlook
current
challenges
opportunities
future
directions
wearable
Chemical Reviews,
Год журнала:
2019,
Номер
119(8), С. 5461 - 5533
Опубликована: Янв. 28, 2019
Bio-integrated
wearable
systems
can
measure
a
broad
range
of
biophysical,
biochemical,
and
environmental
signals
to
provide
critical
insights
into
overall
health
status
quantify
human
performance.
Recent
advances
in
material
science,
chemical
analysis
techniques,
device
designs,
assembly
methods
form
the
foundations
for
uniquely
differentiated
type
technology,
characterized
by
noninvasive,
intimate
integration
with
soft,
curved,
time-dynamic
surfaces
body.
This
review
summarizes
latest
this
emerging
field
"bio-integrated"
technologies
comprehensive
manner
that
connects
fundamental
developments
chemistry,
engineering
sensing
have
potential
widespread
deployment
societal
benefit
care.
An
introduction
chemistries
materials
active
components
these
contextualizes
essential
design
considerations
sensors
associated
platforms
appear
following
sections.
The
subsequent
content
highlights
most
advanced
biosensors,
classified
according
their
ability
capture
information.
Additional
sections
feature
schemes
electrically
powering
strategies
achieving
fully
integrated,
wireless
systems.
concludes
an
overview
key
remaining
challenges
summary
opportunities
where
chemistry
will
be
critically
important
continued
progress.
Lab on a Chip,
Год журнала:
2017,
Номер
18(2), С. 217 - 248
Опубликована: Ноя. 28, 2017
Wearable
sensors
have
recently
seen
a
large
increase
in
both
research
and
commercialization.
However,
success
wearable
has
been
mix
of
progress
setbacks.
Most
commercial
smart
adaptation
existing
mechanical,
electrical
optical
methods
measuring
the
body.
This
involved
innovations
how
to
miniaturize
sensing
technologies,
make
them
conformal
flexible,
development
companion
software
that
increases
value
measured
data.
chemical
modalities
experienced
greater
challenges
adoption,
especially
for
non-invasive
sensors.
There
also
significant
making
fundamental
improvements
electrical,
modalities,
improving
their
specificity
detection.
Many
these
can
be
understood
by
appreciating
body's
surface
(skin)
as
more
an
information
barrier
than
source.
With
deeper
understanding
faced
state-of-the-art
sensor
technology,
roadmap
becomes
clearer
creating
next
generation
breakthroughs.
Accounts of Chemical Research,
Год журнала:
2019,
Номер
52(3), С. 523 - 533
Опубликована: Фев. 15, 2019
ConspectusWearable
sensors
play
a
crucial
role
in
realizing
personalized
medicine,
as
they
can
continuously
collect
data
from
the
human
body
to
capture
meaningful
health
status
changes
time
for
preventive
intervention.
However,
motion
artifacts
and
mechanical
mismatches
between
conventional
rigid
electronic
materials
soft
skin
often
lead
substantial
sensor
errors
during
epidermal
measurement.
Because
of
its
unique
properties
such
high
flexibility
conformability,
flexible
electronics
enables
natural
interaction
body.
In
this
Account,
we
summarize
our
recent
studies
on
design
devices
systems
physical
chemical
monitoring.
Material
innovation,
design,
device
fabrication,
system
integration,
employed
toward
continuous
noninvasive
wearable
sensing
are
discussed.A
typically
contains
several
key
components,
including
substrate,
active
layer,
interface
layer.
The
inorganic-nanomaterials-based
layer
(prepared
by
transfer
or
solution
process)
is
shown
have
good
physicochemical
properties,
electron/hole
mobility,
strength.
Flexible
based
printed
transferred
has
great
promise
sensing.
For
example,
integrating
nanowire
transistor
array
matrix
conductive
pressure-sensitive
rubber
tactile
pressure
mapping;
tactile-pressure-sensitive
e-skin
organic
light-emitting
diodes
be
integrated
instantaneous
visualization.
Such
been
applied
patches
monitor
temperature,
electrocardiograms,
activities.
addition,
liquid
metals
could
serve
an
attractive
candidate
because
their
excellent
conductivity,
flexibility,
stretchability.
Liquid-metal-enabled
(based
liquid–liquid
heterojunctions
embedded
microchannels)
utilized
wide
range
physiological
parameters
(e.g.,
pulse
temperature).Despite
rapid
growth
technologies,
there
urgent
need
development
that
molecular
retrieve
more
insightful
information.
We
developed
sweat-sensing
platform
real-time
multiplexed
perspiration
analysis.
An
iontophoresis
module
sweat
enable
autonomous
programmed
extraction.
A
microfluidics-based
was
demonstrated
sampling,
sensing,
rate
Roll-to-roll
gravure
printing
allows
mass
production
high-performance
at
low
cost.
These
dehydration
monitoring,
cystic
fibrosis
diagnosis,
drug
glucose
monitoring.Future
work
field
should
focus
designing
robust
accurately
large-scale
determine
how
measured
information
relates
individual's
specific
conditions.
Further
research
these
directions,
along
with
large
sets
collected
via
will
significant
impact
future
healthcare.
Advanced Materials,
Год журнала:
2019,
Номер
32(15)
Опубликована: Июль 8, 2019
Abstract
Recent
advances
in
soft
materials
and
system
integration
technologies
have
provided
a
unique
opportunity
to
design
various
types
of
wearable
flexible
hybrid
electronics
(WFHE)
for
advanced
human
healthcare
human–machine
interfaces.
The
biocompatible
with
miniaturized
wireless
systems
is
undoubtedly
an
attractive
prospect
the
sense
that
successful
device
performance
requires
high
degrees
mechanical
flexibility,
sensing
capability,
user‐friendly
simplicity.
Here,
most
up‐to‐date
materials,
sensors,
system‐packaging
develop
WFHE
are
provided.
Details
mechanical,
electrical,
physicochemical,
properties
discussed
integrated
sensor
applications
healthcare,
energy,
environment.
In
addition,
limitations
current
discussed,
as
well
key
challenges
future
direction
WFHE.
Collectively,
all‐inclusive
review
newly
developed
along
summary
imperative
requirements
material
properties,
capabilities,
performance,
skin
integrations
