Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(3), С. 54 - 54
Опубликована: Март 7, 2024
Background:
Painful
diabetic
neuropathy
(pDN)
is
the
most
common
cause
of
neuropathic
pain
(NP)
in
United
States.
Prolonged
continuous
theta
burst
stimulation
(pcTBS),
a
form
repetitive
transcranial
magnetic
(rTMS),
quick
(1–4
minutes)
and
tolerable
for
individuals,
compared
to
high
frequency
rTMS
can
modulate
thresholds
healthy
participants.
However,
its
effects
on
patients
with
chronic
are
still
unclear.
The
primary
purpose
this
preliminary
study
investigate
single
session
pcTBS
targeted
at
motor
cortex
(M1)
dorsolateral
prefrontal
(DLPFC)
set
self-report
measures
(SRMP)
that
assess
(a)
sensory-discriminative;
(b)
affective-motivational;
(c)
cognitive-evaluative
aspects
experience.
Methods:
For
prospective,
single-blind
study,
forty-two
participants
pDN
were
randomized
receive
either
targeting
M1
or
DLPFC
brain
regions.
SRMP
completed
baseline,
post
24h-post
pcTBS.
A
two-way
mixed
model
repeated
analysis
variance
(2
regions
by
3
time
points)
was
conducted
evaluate
each
subscale
SRMP.
Results:
After
pDN,
statistically
significant
improvements
from
baseline
24
h-post
observed
different
subscales
examining
sensory-discriminative,
affective-motivational
components
At
pcTBS,
none
reported
any
serious
adverse
events
treatment,
thus
demonstrating
feasibility.
Conclusions:
In
NP,
our
results
demonstrated
improvement
scores
after
Future
studies
should
consider
utilizing
multiple
sessions
long-term
perception,
safety
tolerability
pain.
Clinical
Trial
Registration:
This
registered
ClinicalTrials.gov
website
(NCT04988321).
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июнь 8, 2024
Abstract
Pain
is
estimated
to
affect
more
than
20%
of
the
global
population,
imposing
incalculable
health
and
economic
burdens.
Effective
pain
management
crucial
for
individuals
suffering
from
pain.
However,
current
methods
assessment
treatment
fall
short
clinical
needs.
Benefiting
advances
in
neuroscience
biotechnology,
neuronal
circuits
molecular
mechanisms
critically
involved
modulation
have
been
elucidated.
These
research
achievements
incited
progress
identifying
new
diagnostic
therapeutic
targets.
In
this
review,
we
first
introduce
fundamental
knowledge
about
pain,
setting
stage
subsequent
contents.
The
review
next
delves
into
underlying
disorders,
including
gene
mutation,
epigenetic
modification,
posttranslational
inflammasome,
signaling
pathways
microbiota.
To
better
present
a
comprehensive
view
research,
two
prominent
issues,
sexual
dimorphism
comorbidities,
are
discussed
detail
based
on
findings.
status
quo
evaluation
manipulation
summarized.
A
series
improved
innovative
strategies,
such
as
therapy,
monoclonal
antibody,
brain-computer
interface
microbial
intervention,
making
strides
towards
application.
We
highlight
existing
limitations
future
directions
enhancing
quality
preclinical
research.
Efforts
decipher
complexities
pathology
will
be
instrumental
translating
scientific
discoveries
practice,
thereby
improving
bench
bedside.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(5), С. 2685 - 2685
Опубликована: Фев. 28, 2022
Neuropathic
pain
indicates
caused
by
damage
to
the
somatosensory
system
and
is
difficult
manage
treat.
A
new
treatment
strategy
urgently
needs
be
developed.
Both
autophagy
apoptosis
are
critical
adaptive
mechanisms
when
neurons
encounter
stress
or
damage.
Recent
studies
have
shown
that,
after
nerve
damage,
both
autophagic
apoptotic
activities
in
injured
nerve,
dorsal
root
ganglia,
spinal
horn
change
over
time.
Many
that
upregulated
may
help
myelin
clearance,
promote
regeneration,
attenuate
behavior.
On
other
hand,
there
no
direct
evidence
inhibition
of
can
Most
only
agents
simultaneously
behavior
inhibit
ganglia.
Autophagy
crosstalk
with
each
through
various
proteins
proinflammatory
cytokine
expressions.
Proinflammatory
cytokines
autophagic/apoptotic
neuropathic
formation,
whereas
further
behaviors.
Thus,
enhance
but
suppress
on
ganglia
treat
pain.
Here,
we
summarized
evolving
changes
cord,
brain
This
review
understanding
for
during
injury
modulating
apoptotic/autophagic
nervous
system.
Journal of Medical Case Reports,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 28, 2023
Severe
forms
of
depression
have
been
linked
to
hyperactivity
the
subcallosal
cingulate
cortex.
The
ability
stimulate
cortex
or
associated
circuits
noninvasively
and
directly
would
maximize
number
patients
who
could
receive
treatment.
To
this
end,
we
developed
an
ultrasound-based
device
for
effective
noninvasive
modulation
deep
brain
circuits.
Here
describe
application
tool
individual
with
treatment-resistant
depression.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Апрель 8, 2024
Periaqueductal
gray
(PAG),
an
integration
center
for
neuronal
signals,
is
located
in
the
midbrain
and
regulates
multiple
physiological
pathological
behaviors,
including
pain,
defensive
aggressive
anxiety
depression,
cardiovascular
response,
respiration,
sleep-wake
behaviors.
Due
to
different
neuroanatomical
connections
functional
characteristics
of
four
columns
PAG,
subregions
PAG
synergistically
regulate
various
instinctual
In
current
review,
we
summarized
role
possible
neurobiological
mechanism
regulation
anxiety,
depression
from
perspective
up-down
circuits
PAG.
Furthermore,
proposed
potential
clinical
applications
Knowledge
these
aspects
will
give
us
a
better
understanding
key
behaviors
provide
directions
future
treatments.
Cells,
Год журнала:
2024,
Номер
13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine
is
a
debilitating
neurological
disorder
characterized
by
recurring
episodes
of
throbbing
headaches
that
are
frequently
accompanied
sensory
disturbances,
nausea,
and
sensitivity
to
light
sound
[...]
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Май 10, 2024
In
modern
times
there
is
increasing
acceptance
that
music-based
interventions
are
useful
aids
in
the
clinical
treatment
of
a
range
neurological
and
psychiatric
conditions,
including
helping
to
reduce
perception
pain.
Indeed,
belief
music,
whether
listening
or
performing,
can
alter
human
pain
experiences
has
long
history,
dating
back
ancient
Greeks,
its
potential
healing
properties
have
been
appreciated
by
indigenous
cultures
around
world.
The
subjective
experience
acute
chronic
complex,
influenced
many
intersecting
physiological
psychological
factors,
it
therefore
be
expected
impact
music
therapy
on
may
vary
from
one
situation
another,
person
another.
Where
persists
becomes
chronic,
aberrant
central
processing
key
feature
associated
with
ongoing
experience.
Nonetheless,
beneficial
effects
exposure
relief
reported
across
wide
shown
effective
neonates,
children
adults.
this
comprehensive
review
we
examine
various
neurochemical,
factors
underpin
experience,
potentially
operate
at
levels
–
periphery,
spinal
cord,
brainstem,
limbic
system
multiple
areas
cerebral
cortex.
We
discuss
extent
which
these
individually
combination,
influence
how
affects
both
quality
intensity
pain,
noting
remains
controversy
about
respective
roles
diverse
peripheral
processes
play
Better
understanding
mechanisms
underlie
music’s
together
insights
into
should
aid
developing
more
synergistic
approaches
when
combined
treatments.
ubiquitous
nature
also
facilitates
application
therapeutic
environment
daily
life,
for
individual
social
benefit.
