Trends in cancer, Год журнала: 2024, Номер 10(5), С. 386 - 388
Опубликована: Апрель 21, 2024
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 8, 2024
Demyelination is a common pathological feature in wide range of diseases, characterized by the loss myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability axons damage, result significant brain atrophy neuro-axonal degeneration. Multiple pathomolecular processes contribute neuroinflammation, oligodendrocyte cell death, progressive neuronal dysfunction. In this study, we use cuprizone mouse model demyelination investigate long-term non-invasive gamma entrainment using sensory stimulation as potential therapeutic intervention for promoting myelination reducing neuroinflammation male mice. Here, show that multisensory mitigates demyelination, promotes oligodendrogenesis, preserves functional integrity synaptic plasticity, attenuates ferroptosis-induced reduces inflammation. Thus, protective effects on anti-neuroinflammatory properties support its approach demyelinating disorders.
Язык: Английский
Процитировано
6
NeuroImage, Год журнала: 2024, Номер unknown, С. 120945 - 120945
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
American Journal Of Pathology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Alzheimer's disease (AD) is the most common type of dementia and one leading causes death in elderly patients. The number patients with AD United States projected to double by 2060. Thus, understanding modifiable risk factors for an urgent public health priority. In parallel patients, cancer survivors estimated increase significantly, up 80% treated chemotherapy will develop cognitive deficits, termed chemotherapy-related impairment (CRCI). This Review discusses biologically plausible pathways underlying both disorders, goal why a proportion may be at higher developing AD. Highlighted are E4 allele apolipoprotein E gene, neuroinflammation, oxidative stress, DNA damage, mitochondrial dysfunction, neuronal synaptic loss, cellular senescence, brain-derived neurotrophic factor signaling, white matter blood-brain barrier/vascular tau pathology, transposable element reactivation.
Язык: Английский
Процитировано
0
PLoS Biology, Год журнала: 2025, Номер 23(2), С. e3003046 - e3003046
Опубликована: Фев. 28, 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. There no known cure for AD, highlighting an urgent need new, innovative treatments. Recent studies have shed light on promising, noninvasive approach using sensory stimulation as potential therapy AD. Exposing patients to and sound pulses at frequency of 40 hertz induces brain rhythms in the gamma range that are important healthy activity. Using this treatment animal models, we now beginning understand molecular, cellular, circuit-level changes underlie improvements pathology, cognition, behavior. A mechanistic understanding basic biology underlies 40-hertz will inform ongoing clinical trials offer promising avenue without side effects high costs typically associated with pharmacological interventions. Concurrent advancements neurotechnology can also noninvasively stimulate illuminating new possibilities alternative therapies. Altogether, these approaches could herald era treating making them beacon hope patients, families, caregivers facing challenges debilitating condition.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 9, 2025
Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of in bioengineering medicine. In this review, basic principles constructing along with latest progress research comprehensively summarized. Then, application for diagnosis neurodegenerative diseases (NDDs) is systematically described. addition, significant potential broad prospects treatment NDDs highlighted from several aspects, including disaggregation neurofibrils, scavenging reactive oxygen species, regulation microbial-gut-brain axis, elimination senescent cells, promotion directed differentiation neural stem cells. Finally, a perspective challenges future provided.
Язык: Английский
Процитировано
0
Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cancer Research, Год журнала: 2024, Номер 84(13), С. 2041 - 2042
Опубликована: Апрель 24, 2024
Many patients with cancer are at risk of developing cognitive symptoms that often become evident during or after cancer-directed therapy and may have difficulties attention, concentration, multitasking, executive function, memory. Despite recent advances in identifying potential molecular cellular mechanisms underlying chemotherapy-related impairment, there is generally a lack effective treatment strategies, the development novel therapeutic interventions represents major unmet medical need clinical practice. A study by Kim colleagues suggests multisensory 40-Hz gamma entrainment using sensory stimuli combined visual auditory associated powerful neuroprotective effects mouse models cisplatin- methotrexate-induced "chemobrain." Although has some limitations successful animal failed to translate into practice, this noninvasive modality shown promise preserving brain structure function could be tested who decline.
Язык: Английский
Процитировано
3
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105681 - 105681
Опубликована: Апрель 17, 2024
Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited, highlighting need for innovative therapeutic approaches. Gamma Entrainment Using Sensory Stimulation (GENUS) an emerging treatment disorders uses sensory stimulation to entrain impaired oscillatory network activity and restore brain function. Aberrant often underlies experienced by patients schizophrenia. We propose GENUS has potential This paper reviews current status schizophrenia explores use as adjunctive treatment, specifically through gamma entrainment. Impaired frequency entrainment observed in patients, particularly response auditory visual stimuli. Thus, stimulation, such music listening, may have individuals holds novel improve lives schizophrenia, but further research required determine efficacy GENUS, optimize its delivery window, develop strategies implementation specific patient populations.
Язык: Английский
Процитировано
1
eLife, Год журнала: 2024, Номер 13
Опубликована: Ноя. 20, 2024
Gamma oscillations in brain activity (30–150 Hz) have been studied for over 80 years. Although the past three decades significant progress has made to try understand their functional role, a definitive answer regarding causal implication perception, cognition, and behavior still lies ahead of us. Here, we first review basic neural mechanisms that give rise gamma then focus on two main pillars exploration. The pillar examines major theories role information processing brain, also highlighting critical viewpoints. second reviews novel research direction proposes therapeutic oscillations, namely entrainment using sensory stimulation (GENUS). We extensively discuss both positive findings issues reproducibility GENUS. Going beyond gamma, propose third exploration, where generated endogenously by cortical circuits, is essential maintenance healthy circuit function. four classes interneurons, those expressing parvalbumin (PV), vasointestinal peptide (VIP), somatostatin (SST), nitric oxide synthase (NOS) take advantage endogenous perform active vasomotor control maintains homeostasis neuronal tissue. According this hypothesis, which call GAMER (GAmma MEdiated ciRcuit maintenance), act as ‘servicing’ rhythm enables efficient translation into vascular responses are optimal neurometabolic processes. an extension GENUS, rather than entrained plays fundamental role. Finally, several experiments test hypothesis.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 28, 2024
ABSTRACT Modulatory neurotransmitters exert powerful control over neurons and the brain vasculature. Gamma Entrainment Using Sensory Stimuli (GENUS) promotes amyloid clearance via increased perivascular cerebral spinal fluid (CSF) flux in mouse models of Alzheimer’s Disease. Here we use whole-brain activity mapping to identify cholinergic basal forebrain as a key region responding GENUS. In line with this, GENUS promoted cortical acetylcholine release, vascular dilation, vasomotion clearance. Inhibiting signaling abolished effects GENUS, including promotion arterial pulsatility, periarterial CSF influx, reduction levels. Our findings establish an essential component brain’s ability promote non-invasive sensory stimulation.
Язык: Английский
Процитировано
0