Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 117 - 117
Опубликована: Янв. 25, 2025
Background:
Psychedelics
are
increasingly
recognized
as
a
promising
and
innovative
treatment
strategy
for
several
mental
disorders.
However,
there
is
still
lively
controversy
in
the
medical
community
regards
rationale
of
their
employment,
specifically
indications
potential
dangers.
Methods:
A
comprehensive
literature
search
on
“MEDLINE/PubMed”
“Web
Science”
was
performed
from
inception
to
26
June
2024,
cross-checking
obtained
references.
We
included
all
studies,
i.e.,
both
clinical
preclinical,
that
supplied
original
data.
Results:
initially
total
1083
entries,
813
MEDLINE/PubMed
270
Web
Science.
After
duplicate
elimination,
903
underwent
systematic
selection.
Primary
abstract
screening
yielded
572
candidates
eligibility
assessment
excluded
331
entries
formal
grounds.
Eligibility
led
exclusion
501
titles.
Finally,
70
articles
were
this
review.
Discussion:
Preclinical
evidence
genetic
expression,
histology
behavioral
studies
soundly
consistent
with
psychedelics
possessing
neuroplasticity-inducing
properties.
Despite
methodological
difficulties,
seems
be
inferentially
agreement
preclinical
findings.
it
unclear
whether
“neuroplastic
boost”
induced
by
classic
might
dissociable
psychodysleptic
effects,
thereby
reducing
psychopathological
hazards
implied
these
compounds.
Moreover,
fact
so-called
“relaxation
priors”
should
unconditionally
beneficial
appears
debatable,
further
research
clarify
possible
contraindications
psychedelic
psychoplastogens
within
precision
medicine
perspective.
Язык: Английский
Examining memory reconsolidation as a mechanism of nitrous oxide’s antidepressant action
Neuropsychopharmacology,
Год журнала:
2025,
Номер
50(4), С. 609 - 617
Опубликована: Янв. 17, 2025
There
is
an
ongoing
need
to
identify
novel
pharmacological
agents
for
the
effective
treatment
of
depression.
One
emerging
candidate,
which
has
demonstrated
rapid-acting
antidepressant
effects
in
treatment-resistant
groups,
nitrous
oxide
(N2O)-a
gas
commonly
used
sedation
and
pain
management
clinical
settings
with
a
range
effects,
including
antagonism
NMDA
glutamate
receptors.
A
growing
body
evidence
suggests
that
subanaesthetic
doses
N2O
(50%)
can
interfere
reconsolidation
maladaptive
memories
healthy
participants
across
disorders.
Negative
biases
memory
play
key
role
onset,
maintenance,
recurrence
depressive
episodes,
disruption
affective
one
plausible
mechanism
through
exerts
its
therapeutic
effects.
Understanding
N2O's
mechanisms
action
may
facilitate
future
development
In
this
narrative
review,
we
introduce
supporting
profile
evaluate
use
compared
other
treatments.
With
focus
on
specific
processes
are
thought
be
disrupted
depression,
consider
propose
memory-based
action.
Язык: Английский
Delivering a new generation of translational animal models for depression research
Behavioural Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Early
animal
models
of
depression
focused
on
developing
methods
that
could
predict
treatment
efficacy
and
were
validated
based
pharmacological
responses
to
known
antidepressants.
As
our
understanding
major
depressive
disorder
(MDD)
the
pharmacology
antidepressants
progressed,
so
did
need
for
better
models.
This
was
met
with
development
new
disease
models,
such
as
chronic
mild
stress
model,
behavioural
readouts
sucrose
preference
test,
which
more
closely
aligned
risk
factors
symptoms
seen
in
patients.
These
approaches
have
supported
huge
advances
how
affects
brain
impacts
reward-related
behaviours.
However,
there
remain
significant
challenges
when
trying
model
complex
psychiatric
disorders
non-human
animals.
In
this
perspective
article,
a
brief
history
associated
is
discussed
specific
reference
important
contributions
from
Paul
Willner.
The
main
discussion
then
focuses
translational
validity
may
support
delivering
objective.
illustrated
example
affective
bias
test
reward
learning
assays,
been
developed
recapitulate
animals
neuropsychological
impairments
observed
MDD
modulation
by
Язык: Английский
Cognitive and affective models of psychedelics in rodents
International review of neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Investigating the effects of different herbal preparations, 5-hydroxytryptophan and involuntary exercise on affective bias modification in male Lister Hooded rats
Behavioural Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Mood
disorders
are
a
prevalent
global
health
concern
with
natural
products,
including
herbal
supplements,
an
increasingly
popular
choice
as
alternative
or
complementary
therapy.
Despite
their
widespread
use,
few
studies
have
tested
the
clinical
efficacy
of
products
explored
underlying
mechanisms
in
animal
models.
Modification
affective
biases
has
been
linked
to
mood
humans
and
models
may
provide
insights
into
potential
antidepressant
effects.
In
this
study,
we
used
translational
rodent
model
bias
modification
investigate
effects
five
commonly
supplements:
Hypericum
perforatum,
that
is,
St.
John's
Wort
(SJW),
Mucuna
pruriens,
Rhodiola
rosea
root
extract,
Valerian
extract
5-hydroxytryptophan.
Exercise
is
also
thought
improve
disorders,
but
reveal
mixed
results
therefore
effect
involuntary
exercise
on
biases.
separate
experiments,
male
Lister
Hooded
rats
were
acutely
treated
SJW,
5-hydroxytryptophan,
underwent
manipulation.
Our
showed
significant
positive
following
treatment
whilst
induced
negative
rats.
No
found
other
acute
treatments.
These
data
suggest
SJW
similar
terms
conventional
antidepressants.
The
observed
suggests
animals
experience
state
exercise-based
therapy
be
less
effective
if
patient
perceives
involuntary.
Язык: Английский
The Affective Bias Test and Reward Learning Assay: Neuropsychological Models for Depression Research and Investigating Antidepressant Treatments in Rodents
Current Protocols,
Год журнала:
2024,
Номер
4(6)
Опубликована: Июнь 1, 2024
The
Affective
Bias
Test
(ABT)
quantifies
acute
changes
in
affective
state
based
on
the
biases
they
generate
an
associative
reward
learning
task.
Reward
Learning
Assay
(RLA)
provides
a
control
assay
for
ABT
and
reward-induced
generated
this
model
are
sensitive
to
core
state.
Both
tasks
involve
training
animals
associate
specific
digging
substrate
with
food
reward.
Animals
learn
discriminate
between
two
substrates
placed
ceramic
bowls,
one
rewarded
unrewarded.
In
ABT,
animal
learns
independent
substrate-reward
associations
fixed
value
following
either
or
drug
manipulation,
under
conditions.
quantified
choice
test
where
exhibit
bias
(make
more
choices)
of
which
is
specifically
related
at
time
learning.
used
investigate
during
as
well
modulation
associated
past
experiences.
RLA
follows
similar
protocol,
but
remains
same
throughout
by
pairing
higher
determine
if
treatments
affect
memory
retrieval
generally.
Studies
depression
models
environmental
enrichment
suggest
that
Each
task
offers
different
insights
into
processing
mechanisms
may
help
improve
translational
validity
studies
benefit
pre-clinical
development.
©
2024
Authors.
Current
Protocols
published
Wiley
Periodicals
LLC.
Basic
Protocol
1:
Bowl
discrimination
2:
3:
-
new
4:
Язык: Английский
Ketamin und Esketamin
Nervenheilkunde,
Год журнала:
2024,
Номер
43(06), С. 366 - 373
Опубликована: Июнь 1, 2024
ZUSAMMENFASSUNG
Ketamin
blickt
bereits
auf
eine
längere
Geschichte
der
Anwendung
in
Psychiatrie
zurück.
Insbesondere
ist
es
den
letzten
2
Dekaden
zur
Behandlung
von
therapieresistenten
Depressionen
erforscht
und
eingesetzt
worden
mit
dem
Enantiomer
Esketamin
Deutschland
für
diese
Indikation
zugelassen.
Hier
wird
vor
allem
als
pharmakologische
Intervention
genutzt.
kann
zudem
atypisches
Psychedelikum
oder
Dissoziativum
bezeichnet
werden,
da
die
Wirkung
einer
charakteristischen
qualitativen
Bewusstseinsänderung
einhergeht.
Insofern
gibt
Ansätze,
psychophänomenologische
therapeutisch
im
Sinne
ketaminaugmentierten
Psychotherapie
zu
nutzen.
Dies
aber
Studienlage
nicht
untermauert.
Im
Artikel
werden
zunächst
Aspekte
vorgestellt,
dann
aktuelle
klinisch-psychiatrische
Anwendungen
letztlich
Überlegung
diskutiert,
erlebte
Bewusstseinsinhalte
psychotherapeutisch
einzubringen.
Effects of psilocybin on uncertain punishment learning
Neurobiology of Learning and Memory,
Год журнала:
2024,
Номер
213, С. 107954 - 107954
Опубликована: Июнь 22, 2024
Язык: Английский
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Psychedelic
drugs
have
seen
a
resurgence
in
interest
as
next
generation
of
psychiatric
medicines
with
potential
rapid‐acting
antidepressants
(RAADs).
Despite
promising
early
clinical
trials,
the
mechanisms
which
underlie
effects
psychedelics
are
poorly
understood.
For
example,
key
questions
such
whether
antidepressant
and
psychedelic
involve
related
or
independent
unresolved.
Preclinical
studies
relevant
animal
models
to
understanding
pharmacology
translating
these
findings
explain
efficacy
safety
patients.
Understanding
action
associated
behavioural
can
also
support
identification
novel
drug
targets
more
effective
treatments.
Here
we
review
approaches
currently
used
quantify
drugs.
We
discuss
conceptual
methodological
issues,
importance
using
clinically
doses
need
consider
possible
sex
differences
preclinical
studies.
Язык: Английский