Virus-Induced Pathogenic Antibodies: Lessons from Long COVID and Dengue Hemorrhage Fever
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1898 - 1898
Опубликована: Фев. 22, 2025
Virus-induced
antibodies
represent
a
dual-edged
sword
in
the
immune
response
to
viral
infections.
While
are
critical
for
neutralizing
pathogens,
some
can
paradoxically
exacerbate
disease
severity
through
mechanisms
such
as
antibody-dependent
enhancement
(ADE),
autoantibody,
and
prolonged
inflammation.
Long
coronavirus
(COVID)
dengue
hemorrhagic
fever
(DHF)
exemplify
conditions
where
pathogenic
play
pivotal
role
progression.
COVID
is
associated
with
persistent
dysregulation
autoantibody
production,
leading
chronic
symptoms
tissue
damage.
In
DHF,
pre-existing
against
virus
contribute
ADE,
amplifying
replication,
activation,
vascular
permeability.
This
review
explores
underlying
these
antibody
responses,
highlighting
shared
pathways
of
comparing
distinct
features
both
conditions.
By
examining
studies,
we
identify
key
lessons
therapeutic
strategies,
vaccine
design,
future
research
aimed
at
mitigating
severe
outcomes
Язык: Английский
Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 4, 2025
Neurodegenerative
diseases
(NDs)
and
Long
COVID
represent
critical
growing
global
health
challenges,
characterized
by
complex
pathophysiological
mechanisms
including
neuronal
deterioration,
protein
misfolding,
persistent
neuroinflammation.
The
emergence
of
innovative
therapeutic
approaches,
such
as
whole-body
hyperthermia
(WBH),
offers
promising
potential
to
modulate
underlying
in
NDs
related
conditions
like
COVID.
WBH,
particularly
fever-range,
enhances
mitochondrial
function,
induces
heat
shock
proteins
(HSPs),
modulates
neuroinflammation—benefits
that
pharmacological
treatments
often
struggle
replicate.
HSPs
HSP70
HSP90
play
pivotal
roles
folding,
aggregation
prevention,
cellular
protection,
directly
targeting
pathological
processes
seen
Alzheimer's,
Parkinson's,
Huntington's
disease.
Preliminary
findings
also
suggest
WBH's
alleviate
neurological
symptoms
COVID,
where
neuroinflammation
serotonin
dysregulation
are
prominent.
Despite
the
absence
robust
clinical
trials,
implications
WBH
extend
immune
modulation
restoration
disrupted
physiological
pathways.
However,
dual
nature
hyperthermia's
effects—balancing
pro-inflammatory
anti-inflammatory
responses—emphasizes
need
for
dose-controlled
applications
stringent
patient
monitoring
minimize
risks
vulnerable
populations.
While
shows
interest,
significant
challenges
remain.
These
include
individual
variability
response,
limited
accessibility
advanced
technologies,
standardized
protocols.
Future
research
must
focus
on
targeted
biomarker
identification,
personalized
treatment
strategies
optimize
efficacy
integration
into
paradigms
could
mark
a
transformative
step
addressing
these
conditions.
Язык: Английский
A Machine-Learning Approach to Finding Gene Target Treatment Options for Long COVID
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Abstract
Long
COVID,
also
known
as
post-acute
sequelae
of
SARS-CoV-2
infection
(PASC),
encompasses
a
range
symptoms
persisting
for
weeks
or
months
after
the
acute
phase
COVID-19.
These
symptoms,
affecting
multiple
organ
systems,
significantly
impact
quality
life.
This
study
employs
machine-learning
approach
to
identify
gene
targets
treating
COVID.
Using
datasets
GSE275334,
GSE270045,
and
GSE157103,
Recursive
Ensemble
Feature
Selection
(REFS)
was
applied
key
genes
associated
with
The
highlights
therapeutic
potential
targeting
such
PPP2CB,
SOCS3,
ARG1,
IL6R,
ECHS1.
Clinical
trials
pharmacological
interventions,
including
dual
antiplatelet
therapy
anticoagulants,
are
explored
their
efficacy
in
managing
COVID-19-related
complications.
findings
suggest
that
machine
learning
can
effectively
biomarkers
targets,
offering
promising
avenue
personalized
treatment
strategies
COVID
patients.
Язык: Английский
Long COVID: General Perceptions and Challenges in Diagnosis and Management
Katia Ozanic,
Aripuanã Sakurada Aranha Watanabe,
Andre Machado
и другие.
COVID,
Год журнала:
2025,
Номер
5(3), С. 41 - 41
Опубликована: Март 12, 2025
On
11
March
2020,
the
World
Health
Organization
(WHO)
declared
a
pandemic
caused
by
SARS-CoV-2,
raising
global
health
concerns.
Reports
of
persistent
and
new
symptoms
following
acute
phase
infection
highlighted
complexities
recovery
prompted
investigation
what
is
now
termed
long
COVID.
Officially
recognized
WHO
in
October
2021,
COVID
presents
various
implications,
though
terminology—such
as
post-COVID
syndrome
post-acute
sequelae
COVID-19
(PASC)—remains
inconsistent,
complicating
diagnostic
standardization.
Long
affects
an
estimated
10%
to
30%
SARS-CoV-2-infected
individuals,
with
common
including
fatigue,
dyspnea,
cognitive
dysfunction,
joint
pain,
all
which
significantly
impair
quality
life.
Public
perception
influenced
factors
like
education
history,
while
misinformation
stigma
hinder
accurate
diagnosis
treatment.
The
absence
biomarkers
overlap
other
post-viral
syndromes
further
complicate
clinical
recognition.
Experts
emphasize
need
for
refined
criteria
integrated
strategies
combining
biomedical
research,
public
policy,
educational
initiatives
improve
management,
address
healthcare
inequalities,
mitigate
impacts
This
review
unveils
state
art
knowledge
gaps
encourage
discussion,
aim
achieving
better
decision-making
awareness
related
Язык: Английский