Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Biomedicines, Год журнала: 2021, Номер 9(6), С. 689 - 689

Опубликована: Июнь 18, 2021

As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as severe threat to lives billions individuals. Lung cancer, malignant tumor with highest mortality rate, brought significant challenges both human and economic development. Natural products may play pivotal role in treating lung diseases. We reviewed published studies relating natural products, used alone or combination US Food Drug Administration-approved drugs, active against acute respiratory syndrome 2 (SARS-CoV-2) cancer from 1 January 2020 31 May 2021. A wide range can be considered promising anti-COVID-19 anti-lung agents have gained widespread attention, including monotherapy for treatment SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, baicalein) (daurisoline, graveospene deguelin, erianin) FDA-approved anti-SARS-CoV-2 (cepharanthine plus nelfinavir, linoleic acid remdesivir) (curcumin cisplatin, celastrol gefitinib). demonstrated potential value assistance nanotechnology, drug therapies, codrug strategy, this “natural remedy” could serve starting point further development these

Язык: Английский

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5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, biochemical and computational screening against SARS-CoV-2

Chemical Papers, Год журнала: 2024, Номер 78(6), С. 3431 - 3441

Опубликована: Март 14, 2024

Abstract Chemical prototypes with broad-spectrum antiviral activity are important toward developing new therapies that can act on both existing and emerging viruses. Binding of the SARS-CoV-2 spike protein to host angiotensin-converting enzyme 2 (ACE2) receptor is required for cellular entry SARS-CoV-2. Toward identifying chemical leads disrupt this interaction, including in presence adaptive mutations found variants like omicron circumvent vaccine, immune, therapeutic antibody responses, we synthesized 5-chloro-3-(2-(2,4-dinitrophenyl)hydrazono)indolin-2-one (H L) from condensation reaction 5-chloroisatin 2,4-dinitrophenylhydrazine good yield. H L was characterised by elemental spectral (IR, electronic, Mass) analyses. The NMR spectrum indicated a keto–enol tautomerism, keto form being more abundant solution. selectively interfere binding receptor-binding domain (RBD) 50% inhibitory concentration (IC 50 ) 0.26 μM, compared an unrelated PD-1/PD-L1 ligand–receptor-binding pair IC 2.06 μM vitro (Selectivity index = 7.9). Molecular docking studies revealed ligand preferentially binds within ACE2 site region distinct where occur. Consistent these models, able interactions RBDs beta, delta, lambda, similar activities. These indicate L-derived compounds potential inhibitors multiple variants, those capable circumventing vaccine immune responses.

Язык: Английский

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Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction

Medicinal Chemistry Research, Год журнала: 2024, Номер 33(4), С. 620 - 634

Опубликована: Март 5, 2024

Abstract Isatin (indol-2,3-dione), a secondary metabolite of tryptophan, has been used as the core structure to design several compounds that have tested and identified potent inhibitors apoptosis, potential antitumor agents, anticonvulsants, antiviral agents. In this work, analogs isatin hybrids synthesized characterized, their activities were established both Aurora A kinase severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike/host angiotensin-converting enzyme II (ACE2) interactions. Amongst hybrids, 6a , 6f 6g 6m exhibited inhibitory (with IC 50 values < 5 $$\mu$$ μ M), with GScore −7.9, −7.6, −8.2 −7.7 kcal/mol, respectively. Compounds 6i showed in blocking SARS-CoV-2 spike/ACE2 binding range 30 −6.4 −6.6 capable inhibiting kinase. Pharmacophore profiling indicated compound tightly fits pharmacophores, while 6d 6l pharmacophore. This work is proof concept some existing cancer drugs may possess properties. Molecular modeling active for each protein adopted different modes, hence interacting set amino acid residues site. The weaker against could be explained by small sizes ligands fail address important interactions ACE2 receptor

Язык: Английский

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Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

The Microbe, Год журнала: 2024, Номер 3, С. 100059 - 100059

Опубликована: Март 23, 2024

In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric stilbenoids, (–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) their monomeric derivative resveratrol (8), identified from several plant species. The natural products 1–3 had been previously evaluated against SARS-CoV-2 protein targets responsible for viral transmission infection. two isomeric compounds displayed a high affinity blocking of spike with human angiotensin-converting enzyme 2 (ACE2). Molecular docking molecular dynamics simulations have used to attempt explain spike/ACE2 complex. hydrophobic properties respective target sites computed compared physicochemical each compound toward site. ADMET/DMPK profiles also demonstrate potential fragments as lead antiviral discovery. These results reported here support experimental data obtained date clearly identify stilbenoid structure class one worthy future during chemical biology and/or drug discovery efforts.

Язык: Английский

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Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant

Molecules, Год журнала: 2024, Номер 29(14), С. 3427 - 3427

Опубликована: Июль 22, 2024

Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points view. The present study focused on isolation, structure determination, pharmacological investigation constituents Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, phenylpropanoids, were identified methanol extract plant. Five these namely, carexines A–E, previously undescribed natural products. All isolated for first time C. ACE-inhibitory activity seven stilbenoid was tested, (–)-hopeaphenol proved to be most active (IC50 7.7 ± 0.9 μM). enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific also conducted. in silico docking ACE affirmed some favorable interactions. In addition, antiproliferative antibacterial effects evaluated.

Язык: Английский

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An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis

Medicinal Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Язык: Английский

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Traditional uses and pharmacological activities of Tetracera alnifolia wild

South African Journal of Botany, Год журнала: 2025, Номер 181, С. 134 - 140

Опубликована: Апрель 19, 2025

Язык: Английский

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Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention

Journal of Natural Medicines, Год журнала: 2021, Номер 76(1), С. 20 - 37

Опубликована: Окт. 8, 2021

Язык: Английский

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The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Nutrients, Год журнала: 2022, Номер 14(7), С. 1390 - 1390

Опубликована: Март 26, 2022

Patients affected by coronavirus disease 2019 (COVID-19) demonstrate a range of hemostasis dysfunctions, such as coagulation dysfunction and changes in blood platelet function, this being major cause death. These complications may also be associated with oxidative stress. Recently, various papers, including some reviews, have suggested that the use dietary bioactive compounds, phenolic play significant role treatment COVID-19. However, while curcumin, resveratrol, myricetin scutellarian, been found to antiviral effects against COVID-19, recommendations regarding compounds prevent or reduce risk CVDs during COVID-19 infection remain tentative. The present mini-review examines antioxidant, anti-platelet anticoagulant activities selected possible implications for their treating This review whether these can promising agents modulation While properties well documented vitro vivo studies, particularly positive prophylaxis CVDs, less is known prophylactic potential no credible evidence exists efficiency humans animals. In cases, studies are available. Therefore, it cannot unequivocally stated offers benefits patients

Язык: Английский

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Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production

Nutrients, Год журнала: 2022, Номер 14(11), С. 2194 - 2194

Опубликована: Май 25, 2022

Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease has emerged in 2019. The COVID-19-associated pandemic considerably affected the way of life and economy world. It consequently crucial to find solutions allowing remedying or alleviating effects this disease. Natural products have been perpetual application from immemorial time given that they are attested be efficient towards several illnesses without major side effects. Various studies shown plant extracts purified molecules a promising inhibiting impact coronavirus. In addition, it substantial understand characteristics, susceptibility diet on patients infected with COVID-19. review, we recapitulate influence pure medicinal plants We approach possibilities treatment/co-treatment feeding applied also show complications associated nutrient deficiencies then discuss food groups COVID-19 pathogenesis. Then, covered emerging technologies using plant-based SARS-CoV-2 vaccine. conclude giving curative therapy recommendations which potential interest infection could pave for pharmacological treatments co-treatments

Язык: Английский

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