Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Biomedicines, Journal Year: 2021, Volume and Issue: 9(6), P. 689 - 689

Published: June 18, 2021

As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as severe threat to lives billions individuals. Lung cancer, malignant tumor with highest mortality rate, brought significant challenges both human and economic development. Natural products may play pivotal role in treating lung diseases. We reviewed published studies relating natural products, used alone or combination US Food Drug Administration-approved drugs, active against acute respiratory syndrome 2 (SARS-CoV-2) cancer from 1 January 2020 31 May 2021. A wide range can be considered promising anti-COVID-19 anti-lung agents have gained widespread attention, including monotherapy for treatment SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, baicalein) (daurisoline, graveospene deguelin, erianin) FDA-approved anti-SARS-CoV-2 (cepharanthine plus nelfinavir, linoleic acid remdesivir) (curcumin cisplatin, celastrol gefitinib). demonstrated potential value assistance nanotechnology, drug therapies, codrug strategy, this “natural remedy” could serve starting point further development these

Language: Английский

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5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, biochemical and computational screening against SARS-CoV-2

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3431 - 3441

Published: March 14, 2024

Abstract Chemical prototypes with broad-spectrum antiviral activity are important toward developing new therapies that can act on both existing and emerging viruses. Binding of the SARS-CoV-2 spike protein to host angiotensin-converting enzyme 2 (ACE2) receptor is required for cellular entry SARS-CoV-2. Toward identifying chemical leads disrupt this interaction, including in presence adaptive mutations found variants like omicron circumvent vaccine, immune, therapeutic antibody responses, we synthesized 5-chloro-3-(2-(2,4-dinitrophenyl)hydrazono)indolin-2-one (H L) from condensation reaction 5-chloroisatin 2,4-dinitrophenylhydrazine good yield. H L was characterised by elemental spectral (IR, electronic, Mass) analyses. The NMR spectrum indicated a keto–enol tautomerism, keto form being more abundant solution. selectively interfere binding receptor-binding domain (RBD) 50% inhibitory concentration (IC 50 ) 0.26 μM, compared an unrelated PD-1/PD-L1 ligand–receptor-binding pair IC 2.06 μM vitro (Selectivity index = 7.9). Molecular docking studies revealed ligand preferentially binds within ACE2 site region distinct where occur. Consistent these models, able interactions RBDs beta, delta, lambda, similar activities. These indicate L-derived compounds potential inhibitors multiple variants, those capable circumventing vaccine immune responses.

Language: Английский

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Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: 33(4), P. 620 - 634

Published: March 5, 2024

Abstract Isatin (indol-2,3-dione), a secondary metabolite of tryptophan, has been used as the core structure to design several compounds that have tested and identified potent inhibitors apoptosis, potential antitumor agents, anticonvulsants, antiviral agents. In this work, analogs isatin hybrids synthesized characterized, their activities were established both Aurora A kinase severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike/host angiotensin-converting enzyme II (ACE2) interactions. Amongst hybrids, 6a , 6f 6g 6m exhibited inhibitory (with IC 50 values < 5 $$\mu$$ μ M), with GScore −7.9, −7.6, −8.2 −7.7 kcal/mol, respectively. Compounds 6i showed in blocking SARS-CoV-2 spike/ACE2 binding range 30 −6.4 −6.6 capable inhibiting kinase. Pharmacophore profiling indicated compound tightly fits pharmacophores, while 6d 6l pharmacophore. This work is proof concept some existing cancer drugs may possess properties. Molecular modeling active for each protein adopted different modes, hence interacting set amino acid residues site. The weaker against could be explained by small sizes ligands fail address important interactions ACE2 receptor

Language: Английский

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Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

The Microbe, Journal Year: 2024, Volume and Issue: 3, P. 100059 - 100059

Published: March 23, 2024

In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric stilbenoids, (–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) their monomeric derivative resveratrol (8), identified from several plant species. The natural products 1–3 had been previously evaluated against SARS-CoV-2 protein targets responsible for viral transmission infection. two isomeric compounds displayed a high affinity blocking of spike with human angiotensin-converting enzyme 2 (ACE2). Molecular docking molecular dynamics simulations have used to attempt explain spike/ACE2 complex. hydrophobic properties respective target sites computed compared physicochemical each compound toward site. ADMET/DMPK profiles also demonstrate potential fragments as lead antiviral discovery. These results reported here support experimental data obtained date clearly identify stilbenoid structure class one worthy future during chemical biology and/or drug discovery efforts.

Language: Английский

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Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant

Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3427 - 3427

Published: July 22, 2024

Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points view. The present study focused on isolation, structure determination, pharmacological investigation constituents Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, phenylpropanoids, were identified methanol extract plant. Five these namely, carexines A–E, previously undescribed natural products. All isolated for first time C. ACE-inhibitory activity seven stilbenoid was tested, (–)-hopeaphenol proved to be most active (IC50 7.7 ± 0.9 μM). enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific also conducted. in silico docking ACE affirmed some favorable interactions. In addition, antiproliferative antibacterial effects evaluated.

Language: Английский

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The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1390 - 1390

Published: March 26, 2022

Patients affected by coronavirus disease 2019 (COVID-19) demonstrate a range of hemostasis dysfunctions, such as coagulation dysfunction and changes in blood platelet function, this being major cause death. These complications may also be associated with oxidative stress. Recently, various papers, including some reviews, have suggested that the use dietary bioactive compounds, phenolic play significant role treatment COVID-19. However, while curcumin, resveratrol, myricetin scutellarian, been found to antiviral effects against COVID-19, recommendations regarding compounds prevent or reduce risk CVDs during COVID-19 infection remain tentative. The present mini-review examines antioxidant, anti-platelet anticoagulant activities selected possible implications for their treating This review whether these can promising agents modulation While properties well documented vitro vivo studies, particularly positive prophylaxis CVDs, less is known prophylactic potential no credible evidence exists efficiency humans animals. In cases, studies are available. Therefore, it cannot unequivocally stated offers benefits patients

Language: Английский

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Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3885 - 3885

Published: Sept. 6, 2023

The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia and the industry with aim of developing therapies vaccines that target SARS-CoV-2. Several novel have been approved deployed last three years. However, their clinical application revealed limitations due to rapid emergence viral variants. Therefore, development next-generation SARS-CoV-2 therapeutic agents a high potency safety profile remains priority for global health. Increasing awareness “back nature” approach improving human health prompted renewed interest natural products, especially dietary polyphenols, as an additional strategy treat patients, owing its good profile, exceptional nutritional value, health-promoting benefits (including potential antiviral properties), affordability, availability. Herein, we describe biological properties pleiotropic molecular mechanisms polyphenols curcumin, resveratrol, gossypol inhibitors against variants observed vitro vivo studies. Based on advantages disadvantages obtain maximal benefits, several strategies such nanotechnology (e.g., curcumin-incorporated nanofibrous membranes antibacterial-antiviral ability), lead optimization methylated analog curcumin), combination specific plant extracts micronutrients), broad-spectrum activities broadly inhibits coronaviruses) also emphasized positive factors facilitation anti-SARS-CoV-2 support effective long-term management control.

Language: Английский

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Synthesis, Spectroscopic Characterization, DFT Analysis and Molecular Docking of Mn(II), Co(II) and Ni(II) complexes of Hydrazone Derived from 5-chloroisatin and 2,4-dinitrophenylhydrazine

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1013, P. 123184 - 123184

Published: May 17, 2024

Language: Английский

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Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Due to the significance of variable chemical groups across a wide spectrum modern medicine, it is imperative determine what most widely used group in medical applications with fewest side effects. Ten compounds from ten that are commonly known for their uses were compared terms therapeutic potential and The comparison among selected indicated superiority flavonoids over other multitude utilizations lower Kaempferol quercetin showed higher utilization Whereas alkaloid lowest levels use highest Based on conducted, concluded give priority flavonoid being because they exhibit Within flavonoids, kaempferol two highly recommended be widest range applications. Serious caution should considered before applying alkaloids any service. Understanding characteristics these can aid developing safer more effective treatments medicinal plants.

Language: Английский

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Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention

Journal of Natural Medicines, Journal Year: 2021, Volume and Issue: 76(1), P. 20 - 37

Published: Oct. 8, 2021

Language: Английский

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