Anthelmintic Drugs for Repurposing against Gram-Negative Bacilli Infections

Current Medicinal Chemistry, Год журнала: 2022, Номер 30(1), С. 59 - 71

Опубликована: Июль 14, 2022

Bacterial infections are among the leading causes of death worldwide. The emergence antimicrobial resistance factors threatens efficacy all current agents, with some already made ineffective, and, as a result, there is an urgent need for new treatment approaches. International organizations, such World Health Organization and European Centre Diseases Control, have recognized caused by multi-drug-resistant (MDR) bacteria priority global health action. Classical drug discovery involves in vitro screening candidates, Structure-Activity Relationship analysis, followed vivo testing toxicity. Bringing drugs from bench to bedside huge expenditures time resources. This, along relatively short window therapeutic application antibiotics attributed rapid resistance, has, at least until recently, resulted waning interest antibiotic pharmaceutical companies. In this environment, "repurposing" (defined investigating uses existing approved drugs) has gained renewed interest, reflected several recent studies, may help speed up development process save years expensive research invested development. goal review provide overview scientific evidence on potential anthelmintic targeting Gram-negative bacilli (GNB). particular, we aim to: (i) highlight treatments GNB infections, (ii) their mechanisms action against these bacteria, (iii) summarize outcome preclinical studies that target (iv) critical challenges further repurposing development, (v) list specific be more likely repurposed.

Язык: Английский

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Microbial Proteins in Stomach Biopsies Associated with Gastritis, Ulcer, and Gastric Cancer

Molecules, Год журнала: 2022, Номер 27(17), С. 5410 - 5410

Опубликована: Авг. 24, 2022

(1) Background: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Helicobacter pylori infection a major risk factor, but other microbial species may also be involved. In context an earlier proteomics study serum and biopsies patients with gastroduodenal diseases, we explored here simplified microbiome in these (H. pylori, Acinetobacter baumannii, Escherichia coli, Fusobacterium nucleatum, Bacteroides fragilis) on protein level. (2) Methods: A cohort 75 was divided into groups respect to findings normal gastric mucosa (NGM) disorders such as gastritis, ulcer, (GC). The H. status determined. expression analysis biopsy samples carried out using high-definition mass spectrometry tryptic digest (label-free data-independent quantification statistical analysis). (3) Results: total 304 bacterial matches were detected based two or more peptide hits. Significantly regulated proteins like virulence factor type IV secretion system CagE from found abundance gastritis than GC NGM. This finding could reflect increased involvement inflammation line current hypotheses. Abundant across heat shock elongation factors. (4) Conclusions: Next bulk human proteins, number species-specific stomach some which, those expressed by cag pathogenicity island, provide gateways disease prevention without antibacterial intervention order reduce antibiotic resistance.

Язык: Английский

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Potentially effective antimicrobial treatment for pneumonia caused by isolates of carbapenem-resistant and extensively drug-resistant Acinetobacter baumannii complex species: what can we expect in the future?

Expert Review of Anti-infective Therapy, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Окт. 9, 2024

complex (Abc) is currently a significant cause of difficult-to-treat pneumonia. Due to the high prevalence rates carbapenem- and extensively drug-resistant (CR, XDR) phenotypes, limited antibiotic options are available for effective treatment pneumonia caused by CR/XDR-Abc.

Язык: Английский

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Phenotypic Characterization and Genome Analysis of New Broad-Spectrum Virulent Salmophage, Salmonella Phage KKP_3822, for Biocontrol of Multidrug-Resistant Salmonella enterica Strains

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12930 - 12930

Опубликована: Дек. 1, 2024

is one of the main foodborne pathogens. Irrational antibiotic management has led to an increase in incidence multidrug-resistant strains. Bacteriophages may be alternative method food biopreservation and contribute reducing number poisonings requiring pharmacotherapy. This study aimed isolate a bacteriophage (phage) targeting indigenous (MDR)

Язык: Английский

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Phage biocontrol in water treatment and reuse systems: a nascent field with significant innovation opportunities

Current Opinion in Biotechnology, Год журнала: 2024, Номер 91, С. 103242 - 103242

Опубликована: Дек. 21, 2024

While the use of phages in food and biomedical sectors occurs commercially, their application water sector is less common typically demonstrated at a lower technological readiness level. This so despite potential that have to enhance control problematic bacteria (including pathogens) protect infrastructure within sector. Fulfilling great this nascent field requires more research development. Here, we highlight innovation opportunities discern critical knowledge gaps needs facilitate as precise biocontrol agents First, while advent sequencing technologies made it easier identify bacterial communities understand functional roles, identifying cultivating appropriate can be effective against target research. The large volumes spiked with also require optimizing phage strategy, minimizing associated costs enhancing scaling up. In addition, hosts may gain resistance after long-term exposure, which most water-engineered systems, strategies minimize or delay must considered. opinion, provide an overview pertinent literature bioinformatic tools help for systems applications. We then discuss aid prolonging efficacy feasibility approaches.

Язык: Английский

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