Butyrate-Producing Mixed Probiotics Alleviate MRSA-Induced Acute Lung Injury in Mice by Promoting M2 Macrophage Polarization
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Язык: Английский
Lactic Acid Bacteria Bacteriocins: Safe and Effective Antimicrobial Agents
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4124 - 4124
Опубликована: Апрель 26, 2025
Antibiotic-resistant
bacteria
are
major
contributors
to
food
spoilage,
animal
diseases,
and
the
emergence
of
multidrug-resistant
(MDR)
in
healthcare,
highlighting
urgent
need
for
effective
treatments.
Bacteriocins
produced
by
lactic
acid
(LAB)
have
gained
attention
their
non-toxic
nature
strong
antimicrobial
properties.
LAB-derived
bacteriocins
been
successfully
applied
preservation
classified
U.S.
Food
Drug
Administration
(FDA)
as
'food-grade'
or
'generally
recognized
safe'
(GRAS).
This
review
summarizes
recent
progress
production,
purification,
emerging
applications
LAB
bacteriocins.
It
emphasizes
versatility
preservation,
agriculture,
medicine,
providing
insights
into
role
development
functional
innovation.
Язык: Английский
A narrative review on the physicochemical profiles, bioactive compounds, and therapeutic potentials of stingless bee honey
Nor Liyana Ja’afar,
Nurfaizatul Aisyah Ab Aziz,
Zaida Zakaria
и другие.
Discover Food,
Год журнала:
2025,
Номер
5(1)
Опубликована: Май 22, 2025
Язык: Английский
Rottlerin as a multifaceted antimicrobial agent: inhibiting growth, disrupting biofilms, and enhancing antibiotic efficacy against vancomycin-resistant Enterococcus
Journal of Umm Al-Qura University for Applied Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
Abstract
The
rise
of
vancomycin-resistant
Enterococcus
(VRE)
poses
a
significant
challenge
in
clinical
settings
due
to
its
resistance
conventional
antibiotics
and
ability
form
biofilms,
which
enhance
persistence
virulence.
Despite
extensive
efforts
combat
multidrug-resistant
bacteria,
effective
alternative
treatments
remain
limited.
This
study
investigates
the
antimicrobial
potential
Rottlerin
(RTN)
against
VRE,
addressing
this
gap
by
exploring
inhibit
bacterial
growth,
disrupt
antibiotic
efficacy.
results
demonstrated
that
RTN
effectively
inhibited
growth
exponential-phase
VRE
dose-dependent
manner,
with
Minimum
Inhibitory
Concentration
(MIC)
8
µg/mL.
also
exhibited
potent
anti-biofilm
activity,
reducing
biofilm
formation
65.3%
at
4
µg/mL
clearing
preformed
biofilms
54.8%
µg/mL,
as
confirmed
crystal
violet
staining.
Importantly,
prolonged
exposure
subinhibitory
concentrations
over
18
passages
did
not
induce
resistance,
underscoring
sustainable
agent.
Checkerboard
assays
revealed
synergy
between
vancomycin
or
norfloxacin,
fractional
inhibitory
concentration
index
(FICI)
values
≤
0.5,
suggesting
utility
combination
therapies
disrupted
metabolic
activity
induced
reactive
oxygen
species
(ROS)
production,
most
pronounced
ROS
induction
observed
Collectively,
these
findings
highlight
RTN’s
multifaceted
properties,
including
inhibition,
disruption,
induction,
antibiotics.
These
attributes
position
promising
candidate
for
challenges
posed
infections.
Further
studies
are
warranted
elucidate
mechanisms
action
assess
efficacy
vivo
models.
Язык: Английский
Antibiofilm effects of bacteriocin PCM7-4 on Listeria monocytogenes
PLoS ONE,
Год журнала:
2025,
Номер
20(6), С. e0325109 - e0325109
Опубликована: Июнь 5, 2025
Listeria
monocytogenes
is
a
significant
zoonotic
pathogen
capable
of
forming
biofilms
on
food
and
other
materials,
representing
considerable
risk
to
human
health
animal
husbandry.
The
use
bacteriocins
as
potential
new
antibacterial
antibiofilm
reagents
has
attracted
interest.
This
study
aimed
determine
the
inhibitory
effects
bacteriocin
PCM7−4
L.
biofilm
formation.
In
this
study,
SICs
(1/16
×
MIC,
1/8
MIC)
significantly
inhibited
formation
biofilm.
Bacteriocin
reduced
production
bacterial
extracellular
polysaccharides,
could
decrease
motility,
meanwhile,
number
viability
bacteria
within
RT-qPCR
results
showed
that
expression
flagella,
community
sensing
virulence
factor
genes
associated
with
demonstrated
therapeutic
agent
for
prevention
treatment
biofilms.
Язык: Английский