Nature Immunology, Год журнала: 2013, Номер 15(1), С. 45 - 53
Опубликована: Ноя. 24, 2013
Язык: Английский
Clinical Microbiology Reviews, Год журнала: 2015, Номер 28(3), С. 603 - 661
Опубликована: Май 27, 2015
SUMMARY Staphylococcus aureus is a major human pathogen that causes wide range of clinical infections. It leading cause bacteremia and infective endocarditis as well osteoarticular, skin soft tissue, pleuropulmonary, device-related This review comprehensively covers the epidemiology, pathophysiology, manifestations, management each these entities. The past 2 decades have witnessed two clear shifts in epidemiology S. infections: first, growing number health care-associated infections, particularly seen prosthetic device second, an epidemic community-associated tissue infections driven by strains with certain virulence factors resistance to β-lactam antibiotics. In reviewing literature support strategies for we also highlight paucity high-quality evidence many key questions.
Язык: Английский
Процитировано
4279
The Science of The Total Environment, Год журнала: 2013, Номер 447, С. 345 - 360
Опубликована: Фев. 7, 2013
Язык: Английский
Процитировано
2146
Clinical Microbiology Reviews, Год журнала: 2018, Номер 31(4)
Опубликована: Июль 31, 2018
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, an increasing major health care problem around the world. It is now abundantly clear both Gram-negative and Gram-positive able meet evolutionary challenge combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from bacterial gene pool. This achieved through concerted activities mobile genetic elements move within or between DNA molecules, which include insertion sequences, transposons, cassettes/integrons, transfer cells, such as plasmids integrative conjugative elements. Together these play a central role in facilitating horizontal exchange therefore promote acquisition spread genes. review aims outline characteristics types involved antibiotic bacteria, focusing on so-called ESKAPEE group organisms (
Язык: Английский
Процитировано
1849
Nature Reviews Microbiology, Год журнала: 2019, Номер 17(4), С. 203 - 218
Опубликована: Фев. 8, 2019
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and transmitted in both health-care community settings also leading cause bacteraemia, endocarditis, skin soft tissue infections, bone joint infections hospital-acquired infections. Genetically diverse, epidemiology MRSA primarily characterized by serial emergence epidemic strains. Although its incidence has recently declined some regions, still poses formidable clinical threat, with persistently high morbidity mortality. Successful treatment remains challenging requires evaluation novel antimicrobials adjunctive aspects care, such infectious disease consultation, echocardiography source control. In this Review, we provide an overview basic research summarize expansive body literature on epidemiology, transmission, genetic diversity, evolution, surveillance MRSA. major pathogen within hospitals community. Fowler colleagues explore
Язык: Английский
Процитировано
1578
Clinical Microbiology Reviews, Год журнала: 2018, Номер 31(4)
Опубликована: Сен. 11, 2018
Staphylococcus aureus, a major human pathogen, has collection of virulence factors and the ability to acquire resistance most antibiotics. This is further augmented by constant emergence new clones, making S. aureus "superbug." Clinical use methicillin led appearance methicillin-resistant (MRSA). The past few decades have witnessed existence MRSA clones. Unlike traditional residing in hospitals, clones can invade community settings infect people without predisposing risk factors. evolution continues with buildup reservoir companion food animals. review focuses on imparting better understanding its molecular characterization epidemiology. We first describe origin MRSA, emphasis diverse nature staphylococcal cassette chromosome mec (SCCmec). mecA homologues (mecB, mecC, mecD), SCCmec types (13 been discovered date), their classification criteria are discussed. then describes various typing methods applied study epidemiology evolutionary MRSA. Starting historical continuing advanced whole-genome approaches, collections shed light origin, spread, pathways
Язык: Английский
Процитировано
1310
International Journal of Antimicrobial Agents, Год журнала: 2012, Номер 39(4), С. 273 - 282
Опубликована: Янв. 10, 2012
Язык: Английский
Процитировано
567
Nature Reviews Microbiology, Год журнала: 2015, Номер 13(9), С. 529 - 543
Опубликована: Авг. 14, 2015
Язык: Английский
Процитировано
508
JAMA Internal Medicine, Год журнала: 2013, Номер unknown
Опубликована: Сен. 16, 2013
Estimating the US burden of methicillin-resistant Staphylococcus aureus (MRSA) infections is important for planning and tracking success prevention strategies.
Язык: Английский
Процитировано
451
Clinical Microbiology and Infection, Год журнала: 2014, Номер 20(7), С. 605 - 623
Опубликована: Июнь 3, 2014
Язык: Английский
Процитировано
411
EMBO Molecular Medicine, Год журнала: 2011, Номер 3(3), С. 129 - 141
Опубликована: Янв. 26, 2011
Abstract Staphylococcus aureus is a frequent cause for serious, chronic and therapy‐refractive infections in spite of susceptibility to antibiotics vitro . In infections, altered bacterial phenotypes, such as small colony variants (SCVs), have been found. Yet, it largely unclear whether the ability interconvert from wild‐type SCV phenotype only rare clinical and/or just laboratory phenomenon or essential sustain an infection. Here, we performed different long‐term vivo infection models with S. show that viable bacteria can persist within host cells tissues several weeks. Persistence induced phenotypic diversity, including accompanied by changes virulence factor expression auxotrophism. However, recovered phenotypes were highly dynamic rapidly reverted fully virulent form when leaving intracellular location infecting new cells. Our findings demonstrate switching integral part process enables hide inside cells, which be reservoir infections. → See accompanying Closeup Christian Garzoni William Kelley DOI 10.1002/emmm.201100123
Язык: Английский
Процитировано
409