Microorganisms,
Год журнала:
2023,
Номер
11(2), С. 259 - 259
Опубликована: Янв. 19, 2023
Antibiotic
resistant
strains
of
bacteria
are
a
serious
threat
to
human
health.
With
increasing
antibiotic
resistance
in
common
pathogens,
fewer
antibiotics
remain
effective
against
infectious
diseases.
Staphylococcus
aureus
is
pathogenic
bacterium
particular
concern
health
as
it
has
developed
many
the
currently
used
leaving
very
few
remaining
treatment.
Alternatives
conventional
needed
for
treating
bacterial
infections.
A
deeper
understanding
cellular
characteristics
beyond
well
characterized
mechanisms
can
allow
increased
ability
properly
treat
them
and
potentially
identify
targetable
changes.
This
review
looks
at
S
relation
its
components,
cell
wall,
membrane
virulence
factors.
Methicillin
most
some
have
even
last
resort
vancomycin
daptomycin.
Modifications
wall
peptidoglycan
teichoic
acids
noted
bacteria.
Alterations
lipids
affect
susceptibility
through
surface
charge,
permeability,
fluidity,
stability
membrane.
Virulence
factors
such
adhesins,
toxins
immunomodulators
serve
versatile
functions
aureus.
New
antimicrobial
strategies
target
including
anti-virulence
treatment
an
adjuvant
traditional
therapy.
Clinical Microbiology Reviews,
Год журнала:
2020,
Номер
33(3)
Опубликована: Май 12, 2020
Antimicrobial-resistant
ESKAPE
(
E
nterococcus
faecium
,
S
taphylococcus
aureus
K
lebsiella
pneumoniae
A
cinetobacter
baumannii
P
seudomonas
aeruginosa
and
nterobacter
species)
pathogens
represent
a
global
threat
to
human
health.
The
acquisition
of
antimicrobial
resistance
genes
by
has
reduced
the
treatment
options
for
serious
infections,
increased
burden
disease,
death
rates
due
failure
requires
coordinated
response
surveillance.
Pathogens,
Год журнала:
2021,
Номер
10(10), С. 1310 - 1310
Опубликована: Окт. 12, 2021
Antibiotics
have
made
it
possible
to
treat
bacterial
infections
such
as
meningitis
and
bacteraemia
that,
prior
their
introduction,
were
untreatable
consequently
fatal.
Unfortunately,
in
recent
decades
overuse
misuse
of
antibiotics
well
social
economic
factors
accelerated
the
spread
antibiotic-resistant
bacteria,
making
drug
treatment
ineffective.
Currently,
at
least
700,000
people
worldwide
die
each
year
due
antimicrobial
resistance
(AMR).
Without
new
better
treatments,
World
Health
Organization
(WHO)
predicts
that
this
number
could
rise
10
million
by
2050,
highlighting
a
health
concern
not
secondary
importance.
In
February
2017,
light
increasing
antibiotic
resistance,
WHO
published
list
pathogens
includes
designated
acronym
ESKAPE
(Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
Enterobacter
species)
which
given
highest
"priority
status"
since
they
represent
great
threat
humans.
Understanding
mechanisms
these
bacteria
is
key
step
development
drugs
tackle
drug-resistant
bacteria.
review,
both
mode
action
commonly
used
antimicrobials
will
be
examined.
It
also
discusses
current
state
AMR
most
critical
resistant
determined
WHO's
global
priority
list.
Virulence,
Год журнала:
2021,
Номер
12(1), С. 547 - 569
Опубликована: Янв. 31, 2021
is
one
of
the
most
frequent
worldwide
causes
morbidity
and
mortality
due
to
an
infectious
agent.
This
pathogen
can
cause
a
wide
variety
diseases,
ranging
from
moderately
severe
skin
infections
fatal
pneumonia
sepsis.
Treatment
Journal of Advanced Research,
Год журнала:
2019,
Номер
21, С. 169 - 176
Опубликована: Окт. 12, 2019
The
infection
caused
by
methicillin-resistant
Staphylococcus
aureus
(MRSA)
is
a
global
threat
to
public
health.
Vancomycin
remains
one
of
the
first-line
drugs
for
treatment
MRSA
infections.
However,
S.
isolates
with
complete
resistance
vancomycin
have
emerged
in
recent
years.
Vancomycin-resistant
(VRSA)
mediated
vanA
gene
cluster,
which
transferred
from
vancomycin-resistant
enterococcus.
Since
first
VRSA
isolate
was
recovered
Michigan,
USA
2002,
52
strains
been
isolated
worldwide.
In
this
paper,
we
review
latest
progresses
VRSA,
highlighting
its
mechanism,
characteristics
infections,
as
well
clinical
treatments.
Antibiotics,
Год журнала:
2019,
Номер
8(2), С. 52 - 52
Опубликована: Май 2, 2019
Staphylococcus
aureus
has
been
an
exceptionally
successful
pathogen,
which
is
still
relevant
in
modern
age-medicine
due
to
its
adaptability
and
tenacity.
This
bacterium
may
be
a
causative
agent
plethora
of
infections,
owing
abundance
(in
the
environment
normal
flora)
variety
virulence
factors
that
it
possesses.
Methicillin-resistant
S.
(MRSA)
strains—first
described
1961—are
characterized
by
altered
penicillin-binding
protein
(PBP2a/c)
resistance
all
penicillins,
cephalosporins,
carbapenems,
makes
β-lactam
armamentarium
clinically
ineffective.
The
acquisition
additional
determinants
further
complicates
their
eradication;
therefore,
MRSA
can
considered
as
first
representative
multidrug-resistant
bacteria.
Based
on
230
references,
aim
this
review
recap
history,
emergence,
clinical
features
various
infections
(hospital-,
community-,
livestock-associated),
summarize
current
advances
regarding
screening,
typing,
therapeutic
options
(including
lipoglycopeptides,
oxazolidinones,
anti-MRSA
novel
pleuromutilin-,
tetracycline-
quinolone-derivatives,
daptomycin,
fusidic
acid,
addition
drug
candidates
development
phase),
both
for
audience
microbiologists
infectious
disease
specialists.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Сен. 7, 2020
Abstract
Owing
to
the
poor
penetration
depth
of
light,
phototherapy,
including
photothermal
and
photodynamic
therapies,
remains
severely
ineffective
in
treating
deep
tissue
infections
such
as
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
osteomyelitis.
Here,
we
report
a
microwave-excited
antibacterial
nanocapturer
system
for
that
consists
microwave-responsive
Fe
3
O
4
/CNT
chemotherapy
agent
gentamicin
(Gent).
This
system,
/CNT/Gent,
is
proven
efficiently
target
eradicate
MRSA-infected
rabbit
tibia
Its
robust
effectiveness
attributed
precise
bacteria-capturing
ability
magnetic
targeting
nanocapturer,
well
subsequent
synergistic
effects
microwaveocaloric
therapy
from
effective
release
antibiotics
infection
sites.
The
advanced
target-nanocapturer
microwaveocaloric-chemotherapy
with
developed
this
study
makes
major
step
forward
microwave
infections.
ACS Nano,
Год журнала:
2020,
Номер
14(10), С. 12905 - 12917
Опубликована: Сен. 18, 2020
Antibacterial
hydrogels
are
attracting
extensive
attention
in
soft
tissue
repair
and
regeneration,
including
bacteria-infected-wound
healing.
The
abuse
of
antibiotics
leads
to
drug
resistance.
Recent
developments
have
demonstrated
that
the
delivery
inorganic
bactericidal
agents
can
drive
wound
healing
process;
however,
this
approach
is
complicated
by
external
light
stimuli,
cytotoxicity,
nondegradability,
sophisticated
fabrication.
Herein,
an
inherent
antibacterial,
bioresorbable
hydrogel
was
developed
spontaneous
self-aggregation
amphiphilic,
oxadiazole-group-decorated
quaternary
ammonium
salts
(QAS)-conjugated
poly(ε-caprolactone)-poly(ethylene
glycol)-poly(ε-caprolactone)
(PCEC-QAS)
micellar
nanoantimicrobials
for
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
cutaneous
PCEC-QAS
showed
a
stable
gel
state
within
temperature
range
5–50
°C
antibacterial
efficacy
against
both
Gram-negative
-positive
bacteria
vitro
vivo.
Additionally,
facilitated
cell
spreading,
proliferation,
migration
without
cytotoxicity.
An
vivo
degradation
skin
defect
study
suggested
totally
absorbed
local
or
systemic
toxicity
could
promote
absence
drugs,
cytokines,
cells.
Significantly,
accelerated
regeneration
MRSA-infected
full-thickness
impaired
successfully
reconstructing
intact
thick
epidermis
similar
normal
mouse
skin.
Collectively,
self-assembling
promising
dressing
material
prevent
bacterial
infection
additional
cells,
irradiation,
systems,
providing
simple
but
effective
strategy
treating
dermal
wounds.
