Microbiology Spectrum, Год журнала: 2023, Номер 11(2)
Опубликована: Фев. 28, 2023
Leptospirosis is a zoonotic disease of global importance. It caused by Gram-negative bacterial spirochete the genus Leptospira .
Язык: Английский
Molecular Microbiology, Год журнала: 2020, Номер 115(3), С. 412 - 424
Опубликована: Дек. 7, 2020
Abstract The type II secretion system (T2SS) is a multi‐protein complex used by many bacteria to move substrates across their cell membrane. Substrates released into the environment serve as local and long‐range effectors that promote nutrient acquisition, biofilm formation, pathogenicity. In both animals plants, T2SS increasingly recognized key driver of virulence. spans bacterial envelope extrudes through an outer membrane secretin channel using pseudopilus. An inner assembly platform cytoplasmic motor controls pseudopilus assembly. This microreview focuses on structure mechanism T2SS. Advances in cryo‐electron microscopy are enabling elaborate sub‐complexes be resolved. However, questions remain regarding extension retraction, how this coupled with choreography substrate moving system. part ancient IV filament superfamily may have been present within last universal common ancestor (LUCA). Overall, mechanistic principles underlie function implication for other closely related systems such tight adherence pilus systems.
Язык: Английский
Процитировано
77
Virulence, Год журнала: 2023, Номер 15(1)
Опубликована: Дек. 6, 2023
Acinetobacter baumannii is a common cause of healthcare-associated infections and hospital outbreaks, particularly in intensive care units. Much the success A. relies on its genomic plasticity, which allows rapid adaptation to adversity stress. The capacity acquire novel antibiotic resistance determinants tolerance stresses encountered environment promote spread among patients long-term contamination healthcare setting. This review explores virulence factors physiological traits contributing infection environment. Several cell-associated secreted involved biofilm formation, cell adhesion, invasion, persistence host, as well xeric stress imposed by settings, are illustrated give reasons for pathogen.
Язык: Английский
Процитировано
37
Microbiology, Год журнала: 2023, Номер 169(3)
Опубликована: Март 22, 2023
Type 4 filaments (T4F) are a superfamily of filamentous nanomachines – virtually ubiquitous in prokaryotes and functionally versatile which type pili (T4P) the defining member. T4F polymers pilins, assembled by conserved multi-protein machineries. They have long been an important topic for research because they key virulence factors numerous bacterial pathogens. Our poor understanding molecular mechanisms assembly is serious hindrance to design anti-T4F therapeutics. This review attempts shed light on fundamental mechanistic principles at play focusing similarities rather than differences between several (mostly bacterial) T4F. holistic approach, complemented revolutionary ability artificial intelligence predict protein structures, led intriguing model assembly.
Язык: Английский
Процитировано
24
PLoS Genetics, Год журнала: 2025, Номер 21(3), С. e1011370 - e1011370
Опубликована: Март 3, 2025
Vibrio species are marine prokaryotes that inhabit diverse ecological niches, colonizing abiotic and biotic surfaces. These bacteria vital players in the global carbon cycle, assimilating billions of tonnes chitin for (and nitrogen) metabolites. Many bacterial proteins involved process-including chitinases, sugar transporters, modifying enzymes-have been well studied. However, genetic functional interplay key drivers competitive survival presence as dominant source is not understood. To address this question, we carried out transposon sequencing (Tn-seq) to determine fitness parahaemolyticus mutants grown on a sole source. Along with validating known genes associated metabolism, our data newly identified roles an unclassified OprD-like import chitoporin HexR family transcriptional regulator. Furthermore, functionally implicated regulating multiple physiological processes V. environmental including assimilation cell growth, biofilm formation, motility. Under nutrient limiting conditions, revealed requirement filamentous morphology, critical trait fitness. Therefore, porin genomic regulation mediated by support chitinolytic growth
Язык: Английский
Процитировано
1
The Protein Journal, Год журнала: 2019, Номер 38(4), С. 389 - 408
Опубликована: Авг. 12, 2019
Язык: Английский
Процитировано
58
Trends in Microbiology, Год журнала: 2020, Номер 28(5), С. 372 - 386
Опубликована: Фев. 13, 2020
Язык: Английский
Процитировано
55
Plants, Год журнала: 2023, Номер 12(11), С. 2207 - 2207
Опубликована: Июнь 3, 2023
Phytopathogenic bacteria not only affect crop yield and quality but also the environment. Understanding mechanisms involved in their survival is essential to develop new strategies control plant disease. One such mechanism formation of biofilms; i.e., microbial communities within a three-dimensional structure that offers adaptive advantages, as protection against unfavorable environmental conditions. Biofilm-producing phytopathogenic are difficult manage. They colonize intercellular spaces vascular system host plants cause wide range symptoms necrosis, wilting, leaf spots, blight, soft rot, hyperplasia. This review summarizes up-to-date information about saline drought stress (abiotic stress) then goes on focus biotic produced by biofilm-forming bacteria, which responsible for serious disease many crops. Their characteristics, pathogenesis, virulence factors, systems cellular communication, molecules implicated regulation these processes all covered.
Язык: Английский
Процитировано
22
Frontiers in Microbiology, Год журнала: 2022, Номер 13
Опубликована: Май 10, 2022
The Fo ATP synthase, the bacterial flagellar motor, and type 9 secretion system (T9SS) are three known proton motive force driven biological rotary motors. In this review, we summarize current information on nuts bolts of T9SS. Torque generation by T9SS, its role in gliding motility bacteria, mechanism via which a T9SS-driven swarm shapes microbiota discussed. knowledge gaps our understanding T9SS machinery outlined.
Язык: Английский
Процитировано
23
Antibiotics, Год журнала: 2023, Номер 12(2), С. 195 - 195
Опубликована: Янв. 17, 2023
Infections led by Acinetobacter baumannii strains are of great concern in healthcare environments due to the strong ability bacteria spread through different apparatuses and develop drug resistance. Severe diseases can be caused A. critically ill patients, but its biological process mechanism not well understood. Secretion systems have recently been demonstrated involved pathogenic process, five types secretion out currently known six from Gram-negative found baumannii. They promote fitness pathogenesis releasing a variety effectors. Additionally, antibiotic resistance is related some systems. In this review, we describe genetic structural compositions that exist Acinetobacter. addition, function molecular each system summarized explain how they enable these critical pathogens overcome eukaryotic hosts prokaryotic competitors cause diseases.
Язык: Английский
Процитировано
16
Microbial Genomics, Год журнала: 2019, Номер 5(6)
Опубликована: Июнь 1, 2019
The type II secretion system (T2SS) plays a major role in promoting bacterial survival the environment and human hosts. One of best characterized T2SS is that Legionella pneumophila , agent Legionnaires’ disease. Secreting at least 25 proteins, including degradative enzymes, eukaryotic-like proteins novel effectors, this contributes to ability L. grow low temperatures, infect amoebal macrophage hosts, damage lung tissue, evade immune system, undergo sliding motility. genes encoding are conserved across genus which includes 62 species >30 pathogens addition . vast majority effectors associated with shared by large number species, hinting critical for them ecology as whole. However, no other has same repertoire with, general rule, phylogenetically more closely related sharing similar sets effectors. involved infection eukaryotic host(s) prevalent throughout indicating they under stronger selective pressure. apparatus closest Aquicella (another parasite amoebae), significant have their homologues Thus, probably originated within order Legionellales some its having arisen -like progenitor, while derived from host, mimiviruses, fungi less bacteria.
Язык: Английский
Процитировано
36