From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

Natural Product Reports, Год журнала: 2018, Номер 35(2), С. 147 - 173

Опубликована: Янв. 1, 2018

Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of the fungus to its environment.

Язык: Английский

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Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

Journal of Industrial Microbiology & Biotechnology, Год журнала: 2018, Номер 46(3-4), С. 281 - 299

Опубликована: Ноя. 27, 2018

Язык: Английский

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Biosynthetic gene clusters and the evolution of fungal chemodiversity

Natural Product Reports, Год журнала: 2020, Номер 37(7), С. 868 - 878

Опубликована: Янв. 1, 2020

This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, andde novoassembly that govern biosynthetic gene cluster diversification and generation chemodiversity in fungi.

Язык: Английский

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Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites

Mycology&#58 An International Journal on Fungal Biology, Год журнала: 2019, Номер 11(1), С. 1 - 21

Опубликована: Июль 31, 2019

Endophytic fungi became an attractive source for the discovery of new leads, because complexity and structural diversity their secondary metabolites. The genus Fusarium comprising about 70 species is extremely variable in terms genetics, biology, ecology, consequently, metabolism have been isolated from countless plants genera diverse habitats. These endophytic microbes may provide protection survival strategies host with production a repertoire chemically structurally unprecedented metabolites reported to exhibit incredible array biological activities including antimicrobial, anticancer, antiviral, antioxidants, antiparasitics, immunosuppressants, immunomodulatory, antithrombotic, biocontrol ability against pathogens nematodes. This review comprehensively highlights over period 1981–2019, bioactive potential produced by endophytes genus.Abbreviations: AIDS: Acquired immune deficiency syndrome; BAPT: C-13 phenylpropanoid side chain-CoA acyltransferase; CaBr2: Calcium bromide; DBAT: 10-deacetylbaccatin III-10-O-acetyl transferase; DNA: Deoxyribonucleic acid; EI-MS: Electron ionization mass spectrometer; EN: Enniatin; ERK: Extracellular regulated protein kinase; EtOAc: Ethyl acetate; FDA: Food Drug Administration; GAE/g: Gallic acid equivalent per gram; GC-MS: Gas chromatography–mass spectrometry; HA: Hyperactivation; HCV: Hepatitis C Virus; HCVPR: Virus protease; HeLa: Human cervical cancer cell line; HIV: immunodeficiency viruses; HPLC: High Performance Liquid Chromatography; IAA: Indole‐3‐acetic IARC: International Agency Research on Cancer; IC50: Half maximal inhibitory concentration; LC50: Concentration compound that lethal 50% exposed population; LC-MS: MCF-7: breast MDR: Multidrug-resistant; MDRSA: Multidrug-resistant S. aureus; MFC: Minimum fungicidal MIC: MRSA: MTCC: Microbial type culture collection; PBMCs: Peripheral blood mononuclear cells; PCR: Polymerase chain reaction; TB: Tuberculosis; TLC: Thin layer chromatography; TNF: Tumor necrosis factor; WHO: World Health Organizationhttp://www.zoobank.org/urn:lsid:zoobank.org:pub:D0A7B2D8-5952-436D-85C8-C79EAAD1013C

Язык: Английский

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Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals

Biotechnology Advances, Год журнала: 2019, Номер 37(6), С. 107344 - 107344

Опубликована: Фев. 10, 2019

Язык: Английский

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The world’s ten most feared fungi

Fungal Diversity, Год журнала: 2018, Номер 93(1), С. 161 - 194

Опубликована: Ноя. 1, 2018

Язык: Английский

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Fungal evolution: cellular, genomic and metabolic complexity

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Год журнала: 2020, Номер 95(5), С. 1198 - 1232

Опубликована: Апрель 17, 2020

The question of how phenotypic and genomic complexity are inter-related they shaped through evolution is a central in biology that historically has been approached from the perspective animals plants. In recent years, however, fungi have emerged as promising alternative system to address such questions. Key their ecological success, present broad diverse range traits. Fungal cells can adopt many different shapes, often within single species, providing them with great adaptive potential. cellular organizations span unicellular forms complex, macroscopic multicellularity, multiple transitions higher or lower levels occurring throughout evolutionary history fungi. Similarly, fungal genomes very architecture. Deep changes genome organization occur quickly, these phenomena known mediate rapid adaptations environmental changes. Finally, biochemical huge, particularly regard secondary metabolites, chemical products aspects biology, including interactions. Herein, we explore interplay cellular, metabolic traits mediates emergence complex phenotypes, this Fungi.

Язык: Английский

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Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

Natural Product Reports, Год журнала: 2021, Номер 38(11), С. 2041 - 2065

Опубликована: Янв. 1, 2021

Here we provide a comprehensive guide for studying natural product biosynthesis using genomics, metabolomics, and their integrated datasets. We emphasize strategies critical outlook on remaining challenges in the field.

Язык: Английский

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Mushroom poisoning epidemiology in the United States

Mycologia, Год журнала: 2018, Номер 110(4), С. 637 - 641

Опубликована: Июль 4, 2018

Ingestion of wild and potentially toxic mushrooms is common in the United States many other parts world. US poison centers have been logging cases mushroom exposure The National Poison Data System (NPDS) annual publications for over 30 years. This study compiles analyzes exposures as reported by NPDS from 1999 to 2016. Over last 18 years, 133 700 (7428/year) exposure, mostly ingestion, reported. Cases are most frequently unintentional (83%, P < 0.001); cause no or only minor harm (86%, children <6 years old (62%, 0.001). Approximately 704 (39/year) resulted major harm. Fifty-two (2.9/year) fatalities reported, cyclopeptide (68-89%)-producing ingested older adults unintentionally. vast majority ingestions harm, although some groups toxins irritants, such cyclopepides, ibotenic acid, monomethylhydrazine, deadly. Misidentification edible species appears be may preventable through education.

Язык: Английский

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Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds

Antibiotics, Год журнала: 2022, Номер 11(11), С. 1604 - 1604

Опубликована: Ноя. 11, 2022

Microorganisms are known as important sources of natural compounds that have been studied and applied for different purposes in distinct areas. Specifically, the pharmaceutical area, fungi explored mainly antibiotics, antiviral, anti-inflammatory, enzyme inhibitors, hypercholesteremic, antineoplastic/antitumor, immunomodulators, immunosuppressants agents. However, historically, high demand new antimicrobial antitumor agents has not sufficiently attended by drug discovery process, highlighting relevance intensifying studies to reach sustainable employment huge world biodiversity, including microorganisms. Therefore, this review describes main approaches tools search bioactive secondary metabolites, well presents several examples produced species with proven pharmacological effects additional fungal cytotoxic molecules. The does cover all metabolites already described; however, it some reports can be useful at any phase applications.

Язык: Английский

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