Light sensing and responses in fungi

Nature Reviews Microbiology, Год журнала: 2018, Номер 17(1), С. 25 - 36

Опубликована: Окт. 30, 2018

Язык: Английский

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Circadian autophagy drives iTRF-mediated longevity

Nature, Год журнала: 2021, Номер 598(7880), С. 353 - 358

Опубликована: Сен. 29, 2021

Язык: Английский

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Light in the Fungal World: From Photoreception to Gene Transcription and Beyond

Annual Review of Genetics, Год журнала: 2019, Номер 53(1), С. 149 - 170

Опубликована: Авг. 27, 2019

Fungi see light of different colors by using photoreceptors such as the White Collar proteins and cryptochromes for blue light, opsins green phytochromes red light. Light regulates fungal development, promotes accumulation protective pigments proteins, tropic growth. The complex (WCC) is a photoreceptor transcription factor that responsible regulating after exposure to In Neurospora crassa, interaction WCCs their binding promoters activate transcription. Aspergillus nidulans, WCC phytochrome interact coordinate gene other responses, but contribution these photobiology varies across species. Ultimately, effect on biology result coordinated transcriptional regulation activation signal transduction pathways.

Язык: Английский

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Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

eLife, Год журнала: 2018, Номер 7

Опубликована: Апрель 26, 2018

The Arabidopsis circadian clock orchestrates gene regulation across the day/night cycle. Although a multiple feedback loop circuit has been shown to generate 24-hr rhythm, it remains unclear how robust is in individual cells, or timing coordinated plant. Here we examine activity at single cell level seedlings over several days under constant environmental conditions. Our data reveal oscillations, albeit desynchronised. In particular, observe two waves of activity; one going down, and up root. We also find evidence cell-to-cell coupling clock, especially root tip. A simple model shows that our measured period differences between cells can observed waves. results spatial structure plant suggest unlike centralised mammalian coordination points.

Язык: Английский

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Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish

Frontiers in Endocrinology, Год журнала: 2019, Номер 10

Опубликована: Июнь 11, 2019

Fish have evolved a biological clock to cope with environmental cycles, so they display circadian rhythms in most physiological functions including stress response. Photoperiodic information is transduced by the pineal organ into rhythmic secretion of melatonin, which released blood circulation high concentrations at night and low during day. Melatonin are under control clocks fish (except salmonids), it considered as an important output system, modulating daily behavioural rhythms. Many factors along hypothalamus-pituitary-interrenal (HPI) axis that controls response fish, corticotropin-releasing hormone (Crh) its binding protein (Crhbp), proopiomelanocortin A B (Pomca Pomcb), plasma cortisol, glucose, lactate. these endogenous molecular clocks, consist self-sustained transcriptional-translational feedback loops involving expression genes (clock, bmal, per cry) persists constant light or darkness. Exposing stressor can result altered indicators, such glucose lactate among others, well behavioral functions. In addition, crh pomca profiles be affected other spectrum, influence profile growth-related (igf1a, igf2a) genes. Additionally, cycle water temperature (warmer day cooler night) another factor has considered. The acute depends also on time when occurs: nocturnal species show higher responses stressed time, whereas diurnal respond stronger night. administration sedative effects reduction locomotor activity cortisol levels, reduced liver glycogen dopaminergic serotonergic activities within hypothalamus. this paper, we reviewing role cycles entrainment HPI fish.

Язык: Английский

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Regulation of plant cell wall degradation by light in Trichoderma

Fungal Biology and Biotechnology, Год журнала: 2018, Номер 5(1)

Опубликована: Апрель 24, 2018

Trichoderma reesei (syn. Hypocrea jecorina) is the model organism for industrial production of plant cell wall degradating enzymes. The integration light and nutrient signals adaptation enzyme in T. emerged as an important regulatory mechanism to be tackled strain improvement. Gene regulation specific cellulase inducing conditions different darkness with substantial by photoreceptors. Genes regulated are clustered genome, several clusters overlapping CAZyme clusters. Major transcription factor genes at least 75% glycoside hydrolase encoding show potential dependent regulation. Accordingly, protein complex formation occurs within promoters cellulases their regulators. Additionally growth on diverse carbon sources between presence photoreceptors cases. Thereby, also intensity plays a role, levels dropping higher intensities background. heterotrimeric G-protein pathway most signaling connection response triggers posttranscriptional expression. All alpha subunits impact manner. downstream cAMP involved well. Connections pathways mainly established via photoreceptor ENV1. effect degradation filamentous fungus Neurospora crassa. In currently proposed model, senses biomass its environment detection building blocks cellulose hemicellulose. Interpretation respective subsequently adjusted requirements (or surface versus substrate) interconnection response. This review provides overview importance light, related degrading enzymes reesei. Additionally, relevance gene fermentations well strategies exploitation observed effects discussed.

Язык: Английский

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Methods used for the study of endophytic fungi: a review on methodologies and challenges, and associated tips

Archives of Microbiology, Год журнала: 2022, Номер 204(11)

Опубликована: Окт. 20, 2022

Язык: Английский

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Red- and Blue-Light Sensing in the Plant Pathogen Alternaria alternata Depends on Phytochrome and the White-Collar Protein LreA

mBio, Год журнала: 2019, Номер 10(2)

Опубликована: Апрель 8, 2019

Light controls many processes in filamentous fungi. The study of light regulation a number model organisms revealed an unexpected complexity. Although the molecular components for sensing appear to be widely conserved fungal genomes, regulatory circuits and sensitivity certain species toward specific wavelengths seem different. In N. crassa , most responses are triggered by blue light, whereas A. nidulans red plays dominant role. Alternaria alternata both important. photoreceptors control morphogenetic pathways, homeostasis reactive oxygen species, production secondary metabolites. On other hand, high-osmolarity required FphA LreA, indicating sophisticated cross talk between stress signaling.

Язык: Английский

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Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

eLife, Год журнала: 2018, Номер 7

Опубликована: Март 16, 2018

Codon usage biases are found in all genomes and influence protein expression levels. The codon effect on was thought to be mainly due its impact translation. Here, we show that transcription termination is an important driving force for bias eukaryotes. Using Neurospora crassa as a model organism, demonstrated introduction of rare codons results premature (PTT) within open reading frames abolishment full-length mRNA. PTT wide-spread phenomenon Neurospora, there strong negative correlation between events. Rare lead the formation putative poly(A) signals PTT. A similar role also observed mouse cells. Together, these suggest co-evolve with machinery suppress thus allow optimal gene expression.

Язык: Английский

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Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster

PLoS Genetics, Год журнала: 2019, Номер 15(6), С. e1008158 - e1008158

Опубликована: Июнь 13, 2019

With the approach of winter, many insects switch to an alternative protective developmental program called diapause. Drosophila melanogaster females overwinter as adults by inducing a reproductive arrest that is characterized inhibition ovarian development at previtellogenic stages. The insulin producing cells (IPCs) are key regulators this process, since they produce and release insulin-like peptides act diapause-antagonizing hormones. Here we show in D. two neuropeptides, Pigment Dispersing Factor (PDF) short Neuropeptide F (sNPF) inhibit arrest, likely through modulation IPCs. In particular, genetic manipulations PDF-expressing neurons, which include sNPF-producing small ventral Lateral Neurons (s-LNvs), modulated levels dormancy, suggesting involvement both neuropeptides. We expressed genetically encoded cAMP sensor IPCs challenged brain explants with synthetic PDF sNPF. Bath applications neuropeptides increased IPCs, even more so when were applied together, synergistic effect. application sNPF additionally Ca2+ Our results indicate dormancy maintaining active state.

Язык: Английский

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