The Microbiota-Gut-Brain Axis

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013

Опубликована: Авг. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Язык: Английский

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The neuroactive potential of the human gut microbiota in quality of life and depression

Nature Microbiology, Год журнала: 2019, Номер 4(4), С. 623 - 632

Опубликована: Фев. 4, 2019

Язык: Английский

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You are what you eat: diet, health and the gut microbiota

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2018, Номер 16(1), С. 35 - 56

Опубликована: Сен. 27, 2018

Язык: Английский

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Clinical metagenomics

Nature Reviews Genetics, Год журнала: 2019, Номер 20(6), С. 341 - 355

Опубликована: Март 27, 2019

Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of microbial and host genetic material (DNA RNA) in samples from patients, is rapidly moving research to clinical laboratories. This emerging approach changing how physicians diagnose treat infectious disease, with applications spanning a wide range areas, including antimicrobial resistance, microbiome, human gene expression (transcriptomics) oncology. Here, we focus on challenges implementing mNGS laboratory address potential solutions for maximizing its impact patient care public health. (mNGS) bench bedside. Review discusses mNGS, disease diagnostics, microbiome analyses, response analyses oncology applications. Moreover, authors review that need be overcome successfully implemented propose maximize benefits patients.

Язык: Английский

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Feature-based molecular networking in the GNPS analysis environment

Nature Methods, Год журнала: 2020, Номер 17(9), С. 905 - 908

Опубликована: Авг. 24, 2020

Язык: Английский

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The microbiome, cancer, and cancer therapy

Nature Medicine, Год журнала: 2019, Номер 25(3), С. 377 - 388

Опубликована: Март 1, 2019

Язык: Английский

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Deciphering cell–cell interactions and communication from gene expression

Nature Reviews Genetics, Год журнала: 2020, Номер 22(2), С. 71 - 88

Опубликована: Ноя. 9, 2020

Язык: Английский

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GABA-modulating bacteria of the human gut microbiota

Nature Microbiology, Год журнала: 2018, Номер 4(3), С. 396 - 403

Опубликована: Ноя. 27, 2018

Язык: Английский

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Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Nature Medicine, Год журнала: 2018, Номер 24(10), С. 1532 - 1535

Опубликована: Авг. 17, 2018

Язык: Английский

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Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Nutrients, Год журнала: 2019, Номер 11(12), С. 2862 - 2862

Опубликована: Ноя. 22, 2019

The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. composition the microbiota unique to each individual tends remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet key modifiable factor influencing microbiota, indicating potential for therapeutic dietary strategies manipulate microbial diversity, composition, stability. While diet can induce shift these changes appear be temporary. Whether prolonged permanent alterations unknown, mainly due lack long-term interventions, or follow-ups short-term interventions. It possible that habitual diets have greater influence on than acute strategies. This review presents current knowledge around response interventions identifies major factors contribute diet. Overall, further research include microbiome measures required before clinical recommendations made modulation health.

Язык: Английский

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