Machine Learning Monte Carlo Approaches and Statistical Physics Notions to Characterize Bacterial Species in Human Microbiota DOI Creative Commons
Michele Bellingeri, Leonardo Mancabelli, Christian Milani

и другие.

Machine Learning and Knowledge Extraction, Год журнала: 2024, Номер 6(4), С. 2375 - 2399

Опубликована: Окт. 18, 2024

Recent studies have shown correlations between the microbiota’s composition and various health conditions. Machine learning (ML) techniques are essential for analyzing complex biological data, particularly in microbiome research. ML methods help analyze large datasets to uncover microbiota patterns understand how these affect human health. This study introduces a novel approach combining statistical physics with Monte Carlo (MC) characterize bacterial species microbiota. We assess significance of different age groups by using notions distances evaluate prevalence abundance across employing MC simulations based on mechanics principles. Our findings show that experiences significant transition from early childhood adulthood. Species such as Bifidobacterium breve Veillonella parvula decrease age, while others like Agathobaculum butyriciproducens Eubacterium rectale increase. Additionally, low-prevalence may hold importance characterizing groups. Finally, we propose an overall ranking integrating proposed here multicriteria classification strategy. research provides comprehensive tool analysis notions, techniques, simulations.

Язык: Английский

The human gut microbiome and aging DOI Creative Commons
Evan S. Bradley, John P. Haran

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Июнь 3, 2024

The composition of the human gut microbiome has been observed to change over course an individual's life. From birth, it is shaped by mode delivery, diet, environmental exposures, geographic location, exposures medications, and aging itself. Here, we present a narrative review across lifespan with focus on its impacts age-related diseases in humans. We will describe how shaped, features that have associated at different phases life this can adversely affect healthy aging. Across lifespan, especially old age, diverse includes organisms suspected produce anti-inflammatory metabolites such as short-chain fatty acids, reported be These findings remarkably consistent regions world suggesting they could universal all cultures genetic backgrounds. Exactly these biologic processes thus promoting crucial targeting for interventions support health longevity.

Язык: Английский

Процитировано

26

Exploring the vitamin biosynthesis landscape of the human gut microbiota DOI Creative Commons
Chiara Tarracchini, Gabriele Andrea Lugli, Leonardo Mancabelli

и другие.

mSystems, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

ABSTRACT The human gut microbiota possesses the capacity to synthesize vitamins, especially B group which are recognized as indispensable for various biological processes both among members of these bacterial communities and host cells. Accordingly, vitamin production by intestinal commensals has attracted significant interest. Nevertheless, our current understanding synthesis is primarily based on individual genomic monoculture investigations, therefore not providing an overall view biosynthetic potential complex microbial communities. In study, we utilized over 100 genes known be involved in biosynthesis K vitamins assess corresponding approximately 8,000 microbiomes. Our analyses reveal that host-associated factors, such age geographical origin, appear influence diversity abundance pathways. Furthermore, identify substantially contribute functions at each stage life. Interestingly, inference co-associations network relationships uncovered apparent key role played folate cobalamin equilibrium establishment infant adult communities, respectively. IMPORTANCE Overall, this study expands microbe-mediated may provide novel targets improve availability essential micronutrients host.

Язык: Английский

Процитировано

14

Early life microbial succession in the gut follows common patterns in humans across the globe DOI Creative Commons
Guilherme Fahur Bottino, Kevin S. Bonham, F. Patel

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

2

Functional modulation of the human gut microbiome by bacteria vehicled by cheese DOI Creative Commons
Christian Milani,

Giulia Longhi,

Giulia Alessandri

и другие.

Applied and Environmental Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

ABSTRACT Since cheese is one of the most commonly and globally consumed fermented foods, scientific investigations in recent decades have focused on determining impact this dairy product human health well-being. However, modulatory effect exerted by autochthonous microbial community taxonomic composition associated functional potential gut microbiota still far from being fully dissected or understood. Here, through use an vitro gut-simulating cultivation model combination with multi-omics approaches, we shown that minor rather than dominant bacterial players are responsible for modulation consumers. These include taxa genera Enterococcus , Bacillus Clostridium, Hafnia . Indeed, they contribute to expand intestinal ecosystem introducing genes production metabolites relevant biological activity, including involved synthesis vitamins, short-chain fatty acids, amino acids. Furthermore, tracing microbiota-associated strains fecal samples consumers provided evidence horizontal transmission events, enabling detection particular transferred humans. Moreover, transcriptomic metabolomic analyses a horizontally transmitted (cheese-to-consumer) strain, i.e., paralvei T10, cultivated environment-simulating medium, confirmed concept cheese-derived bacteria may arsenal consumer’s microbiota. This highlights biologically contributions food microbes acquired consumption health. IMPORTANCE Diet universally recognized as primary factor influencing modulating both taxonomically functionally. In context, cheese, its own microbiota, serves not only source nourishment humans, but also nutrients Additionally, it act vehicle food-associated microorganisms which undergo transfer consumer, potentially host The current study can be traced repertoire significant implications

Язык: Английский

Процитировано

1

Effects of bacteriophages on gut microbiome functionality DOI Creative Commons
Elena Kurilovich, Naama Geva‐Zatorsky

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Март 31, 2025

The gut microbiome, composed of bacteria, fungi, and viruses, plays a crucial role in maintaining the delicate balance human health. Emerging evidence suggests that microbiome disruptions can have far-reaching implications, ranging from development inflammatory diseases cancer to metabolic disorders. Bacteriophages, or "phages", are viruses specifically infect bacterial cells, their interactions with receiving increased attention. Despite recently revived interest phageome, it is still considered "dark matter" gut, more than 80% viral genomes remaining uncharacterized. Today, research focused on understanding mechanisms by which phages influence microbiota potential applications. Bacteriophages may regulate relative abundance communities, affect functions various ways, modulate mammalian host immunity. This review explores how functionality, particularly commensals pathogens, emphasizing health disease.

Язык: Английский

Процитировано

1

Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota DOI
Chiara Tarracchini, Cathy Lordan, Christian Milani

и другие.

Microbiology and Molecular Biology Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

SUMMARYIn recent years, exhaustive efforts have been made to dissect the composition of gut-associated microbial communities and associated interactions with their human host, which are thought play a crucial role in host development, physiology, metabolic functions. Although such studies were initially focused on description compositional shifts microbiota that occur between different health conditions, more recently, they provided key insights into functional contributions gut overall physiology. In this context, an important activity is believed be represented by synthesis various vitamins may elicit considerable benefits health. A growing body scientific literature now available relating (predicted) bacterial vitamin biosynthetic abilities, ever-growing information concerning prevalence these abilities among members microbiota. This review aimed at disentangling if how cooperative trophic contribute production, such, microbiota-mediated production varies according life stages. Moreover, it offers brief exploration diets influence shaping while also providing preliminary potential correlations microbiota-associated occurrence diseases and/or disorders.

Язык: Английский

Процитировано

1

Association of niacin intake and metabolic dysfunction-associated steatotic liver disease: findings from National Health and Nutrition Examination Survey DOI Creative Commons
Jing Zhou, Jun Hyun Han

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 8, 2024

This study aims to explore the relationship between niacin intake and prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) within a large, multi-ethnic cohort.

Язык: Английский

Процитировано

3

Inter-individual variation in human microbiota drives differential impacts on the fermentability of insoluble bran by soluble β-glucans from whole barley DOI
Songtao Fan,

Yiwei Ding,

Zikang Hu

и другие.

Food Hydrocolloids, Год журнала: 2024, Номер unknown, С. 111034 - 111034

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

3

System Overview from Physiological and Pathological Standpoints DOI
Gustavo Rodrigues Pedrino,

Luíza Toubas Chaul,

Virgínia Farias Alves

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Roadmap for alleviating the manifestations of ageing in the cardiovascular system DOI
Luca Liberale, Simon Tual‐Chalot, Simon Sedej

и другие.

Nature Reviews Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0