Machine Learning and Knowledge Extraction,
Год журнала:
2024,
Номер
6(4), С. 2375 - 2399
Опубликована: Окт. 18, 2024
Recent
studies
have
shown
correlations
between
the
microbiota’s
composition
and
various
health
conditions.
Machine
learning
(ML)
techniques
are
essential
for
analyzing
complex
biological
data,
particularly
in
microbiome
research.
ML
methods
help
analyze
large
datasets
to
uncover
microbiota
patterns
understand
how
these
affect
human
health.
This
study
introduces
a
novel
approach
combining
statistical
physics
with
Monte
Carlo
(MC)
characterize
bacterial
species
microbiota.
We
assess
significance
of
different
age
groups
by
using
notions
distances
evaluate
prevalence
abundance
across
employing
MC
simulations
based
on
mechanics
principles.
Our
findings
show
that
experiences
significant
transition
from
early
childhood
adulthood.
Species
such
as
Bifidobacterium
breve
Veillonella
parvula
decrease
age,
while
others
like
Agathobaculum
butyriciproducens
Eubacterium
rectale
increase.
Additionally,
low-prevalence
may
hold
importance
characterizing
groups.
Finally,
we
propose
an
overall
ranking
integrating
proposed
here
multicriteria
classification
strategy.
research
provides
comprehensive
tool
analysis
notions,
techniques,
simulations.
The
composition
of
the
human
gut
microbiome
has
been
observed
to
change
over
course
an
individual's
life.
From
birth,
it
is
shaped
by
mode
delivery,
diet,
environmental
exposures,
geographic
location,
exposures
medications,
and
aging
itself.
Here,
we
present
a
narrative
review
across
lifespan
with
focus
on
its
impacts
age-related
diseases
in
humans.
We
will
describe
how
shaped,
features
that
have
associated
at
different
phases
life
this
can
adversely
affect
healthy
aging.
Across
lifespan,
especially
old
age,
diverse
includes
organisms
suspected
produce
anti-inflammatory
metabolites
such
as
short-chain
fatty
acids,
reported
be
These
findings
remarkably
consistent
regions
world
suggesting
they
could
universal
all
cultures
genetic
backgrounds.
Exactly
these
biologic
processes
thus
promoting
crucial
targeting
for
interventions
support
health
longevity.
ABSTRACT
The
human
gut
microbiota
possesses
the
capacity
to
synthesize
vitamins,
especially
B
group
which
are
recognized
as
indispensable
for
various
biological
processes
both
among
members
of
these
bacterial
communities
and
host
cells.
Accordingly,
vitamin
production
by
intestinal
commensals
has
attracted
significant
interest.
Nevertheless,
our
current
understanding
synthesis
is
primarily
based
on
individual
genomic
monoculture
investigations,
therefore
not
providing
an
overall
view
biosynthetic
potential
complex
microbial
communities.
In
study,
we
utilized
over
100
genes
known
be
involved
in
biosynthesis
K
vitamins
assess
corresponding
approximately
8,000
microbiomes.
Our
analyses
reveal
that
host-associated
factors,
such
age
geographical
origin,
appear
influence
diversity
abundance
pathways.
Furthermore,
identify
substantially
contribute
functions
at
each
stage
life.
Interestingly,
inference
co-associations
network
relationships
uncovered
apparent
key
role
played
folate
cobalamin
equilibrium
establishment
infant
adult
communities,
respectively.
IMPORTANCE
Overall,
this
study
expands
microbe-mediated
may
provide
novel
targets
improve
availability
essential
micronutrients
host.
Applied and Environmental Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
ABSTRACT
Since
cheese
is
one
of
the
most
commonly
and
globally
consumed
fermented
foods,
scientific
investigations
in
recent
decades
have
focused
on
determining
impact
this
dairy
product
human
health
well-being.
However,
modulatory
effect
exerted
by
autochthonous
microbial
community
taxonomic
composition
associated
functional
potential
gut
microbiota
still
far
from
being
fully
dissected
or
understood.
Here,
through
use
an
vitro
gut-simulating
cultivation
model
combination
with
multi-omics
approaches,
we
shown
that
minor
rather
than
dominant
bacterial
players
are
responsible
for
modulation
consumers.
These
include
taxa
genera
Enterococcus
,
Bacillus
Clostridium,
Hafnia
.
Indeed,
they
contribute
to
expand
intestinal
ecosystem
introducing
genes
production
metabolites
relevant
biological
activity,
including
involved
synthesis
vitamins,
short-chain
fatty
acids,
amino
acids.
Furthermore,
tracing
microbiota-associated
strains
fecal
samples
consumers
provided
evidence
horizontal
transmission
events,
enabling
detection
particular
transferred
humans.
Moreover,
transcriptomic
metabolomic
analyses
a
horizontally
transmitted
(cheese-to-consumer)
strain,
i.e.,
paralvei
T10,
cultivated
environment-simulating
medium,
confirmed
concept
cheese-derived
bacteria
may
arsenal
consumer’s
microbiota.
This
highlights
biologically
contributions
food
microbes
acquired
consumption
health.
IMPORTANCE
Diet
universally
recognized
as
primary
factor
influencing
modulating
both
taxonomically
functionally.
In
context,
cheese,
its
own
microbiota,
serves
not
only
source
nourishment
humans,
but
also
nutrients
Additionally,
it
act
vehicle
food-associated
microorganisms
which
undergo
transfer
consumer,
potentially
host
The
current
study
can
be
traced
repertoire
significant
implications
The
gut
microbiome,
composed
of
bacteria,
fungi,
and
viruses,
plays
a
crucial
role
in
maintaining
the
delicate
balance
human
health.
Emerging
evidence
suggests
that
microbiome
disruptions
can
have
far-reaching
implications,
ranging
from
development
inflammatory
diseases
cancer
to
metabolic
disorders.
Bacteriophages,
or
"phages",
are
viruses
specifically
infect
bacterial
cells,
their
interactions
with
receiving
increased
attention.
Despite
recently
revived
interest
phageome,
it
is
still
considered
"dark
matter"
gut,
more
than
80%
viral
genomes
remaining
uncharacterized.
Today,
research
focused
on
understanding
mechanisms
by
which
phages
influence
microbiota
potential
applications.
Bacteriophages
may
regulate
relative
abundance
communities,
affect
functions
various
ways,
modulate
mammalian
host
immunity.
This
review
explores
how
functionality,
particularly
commensals
pathogens,
emphasizing
health
disease.
Microbiology and Molecular Biology Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
SUMMARYIn
recent
years,
exhaustive
efforts
have
been
made
to
dissect
the
composition
of
gut-associated
microbial
communities
and
associated
interactions
with
their
human
host,
which
are
thought
play
a
crucial
role
in
host
development,
physiology,
metabolic
functions.
Although
such
studies
were
initially
focused
on
description
compositional
shifts
microbiota
that
occur
between
different
health
conditions,
more
recently,
they
provided
key
insights
into
functional
contributions
gut
overall
physiology.
In
this
context,
an
important
activity
is
believed
be
represented
by
synthesis
various
vitamins
may
elicit
considerable
benefits
health.
A
growing
body
scientific
literature
now
available
relating
(predicted)
bacterial
vitamin
biosynthetic
abilities,
ever-growing
information
concerning
prevalence
these
abilities
among
members
microbiota.
This
review
aimed
at
disentangling
if
how
cooperative
trophic
contribute
production,
such,
microbiota-mediated
production
varies
according
life
stages.
Moreover,
it
offers
brief
exploration
diets
influence
shaping
while
also
providing
preliminary
potential
correlations
microbiota-associated
occurrence
diseases
and/or
disorders.
This
study
aims
to
explore
the
relationship
between
niacin
intake
and
prevalence
of
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
within
a
large,
multi-ethnic
cohort.
