Trends in cancer,
Год журнала:
2024,
Номер
10(5), С. 393 - 406
Опубликована: Март 1, 2024
The
persistence
of
drug-sensitive
tumors
poses
a
significant
challenge
in
cancer
treatment.
concept
bacterial
persisters,
which
are
subpopulation
bacteria
that
survive
lethal
antibiotic
doses,
is
frequently
used
to
compare
residual
disease
cancer.
Here,
we
explore
drug
tolerance
cells
and
bacteria.
We
highlight
the
fact
bacteria,
contrast
cells,
have
been
selected
for
survival
at
population
level
may
therefore
possess
contingency
mechanisms
lack.
precise
drug-tolerant
persisters
still
being
investigated.
Undoubtedly,
by
understanding
common
features
as
well
differences,
we,
field,
can
learn
from
microbiology
find
strategies
eradicate
persisting
cells.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 26, 2025
Recalcitrant
bacterial
infections
can
be
caused
by
various
types
of
dormant
bacteria,
including
persisters
and
viable
but
nonculturable
(VBNC)
cells.
Despite
their
clinical
importance,
we
know
fairly
little
about
dormancy
development
recovery.
Previously,
established
a
correlation
between
protein
aggregation
in
Escherichia
coli.
Here,
present
further
support
for
direct
relationship
both.
Our
experiments
demonstrate
that
aggregates
progressively
sequester
proteins
involved
energy
production,
thereby
likely
causing
ATP
depletion
dormancy.
Furthermore,
structural
features
determine
the
cell's
ability
to
exit
resume
growth.
Proteins
were
shown
first
assemble
liquid-like
condensates
solidify
over
time.
This
liquid-to-solid
phase
transition
impedes
aggregate
dissolution,
preventing
growth
resumption.
data
model
which
structure,
rather
than
cellular
activity,
marks
from
persister
VBNC
state.
are
often
authors
explore
how
composition
structure
affect
this
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 2, 2023
Abstract
Candida
glabrata
is
a
major
fungal
pathogen
notable
for
causing
recalcitrant
infections,
rapid
emergence
of
drug-resistant
strains,
and
its
ability
to
survive
proliferate
within
macrophages.
Resembling
bacterial
persisters,
subset
genetically
drug-susceptible
C.
cells
can
lethal
exposure
the
fungicidal
echinocandin
drugs.
Herein,
we
show
that
macrophage
internalization
induces
cidal
drug
tolerance
in
,
expanding
persister
reservoir
from
which
echinocandin-resistant
mutants
emerge.
We
this
associated
with
non-proliferation
triggered
by
macrophage-induced
oxidative
stress,
deletion
genes
involved
reactive
oxygen
species
detoxification
significantly
increases
mutants.
Finally,
amphotericin
B
kill
intracellular
reducing
resistance.
Our
study
supports
hypothesis
intra-macrophage
recalcitrant/drug-resistant
alternating
strategies
be
developed
eliminate
reservoir.
Biofilm,
Год журнала:
2023,
Номер
5, С. 100122 - 100122
Опубликована: Апрель 7, 2023
Cold
atmospheric-pressure
plasma
(CAP)
has
emerged
as
a
potential
alternative
or
adjuvant
to
conventional
antibiotics
for
the
treatment
of
bacterial
infections,
including
those
caused
by
antibiotic-resistant
pathogens.
The
sub-lethal
CAP
exposures
synergise
antimicrobials
eradication
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(6), С. 852 - 862
Опубликована: Июнь 1, 2024
Antibiotic
resistance,
typically
associated
with
genetic
changes
within
a
bacterial
population,
is
frequent
contributor
to
antibiotic
treatment
failures.
persistence
and
tolerance,
which
we
collectively
term
recalcitrance,
represent
transient
phenotypic
in
the
population
that
prolong
survival
presence
of
lethal
concentrations
antibiotics.
recalcitrance
challenging
detect
investigate-traditionally
studied
under
vitro
conditions,
our
understanding
during
infection
its
contribution
failure
limited.
Recently,
significant
progress
has
been
made
study
antibiotic-recalcitrant
populations
pathogenic
species,
including
Mycobacterium
tuberculosis,
Staphylococcus
aureus,
Salmonella
enterica,
Yersiniae,
context
host
environment.
Despite
diversity
these
pathogens
models,
shared
signals
responses
promote
common
features
vulnerabilities
persisters
tolerant
bacteria
have
emerged.
These
will
be
discussed
here,
along
toward
developing
therapeutic
interventions
better
treat
recalcitrant
pathogens.
Expert Review of Anti-infective Therapy,
Год журнала:
2024,
Номер
22(1-3), С. 87 - 101
Опубликована: Янв. 5, 2024
,
a
human
commensal,
is
also
one
of
the
most
common
and
serious
pathogens
for
humans.
In
recent
years,
its
capacity
to
survive
replicate
in
phagocytic
non-phagocytic
cells
has
been
largely
demonstrated.
these
intracellular
niches,
bacteria
are
shielded
from
immune
response
antibiotics,
turning
host
into
long-term
infectious
reservoirs.
Moreover,
neutrophils
carry
bloodstream,
leading
systemic
spreading
disease.
Despite
threat
posed
by
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Март 31, 2023
The
bulk
of
bacteria
transiently
evading
appropriate
antibiotic
regimes
and
recovered
from
non-resolutive
infections
are
commonly
refer
to
as
persisters.
In
this
mini-review,
we
discuss
how
persisters
stem
the
interplay
between
pathogen
cellular
defenses
mechanisms
its
underlying
heterogeneity.
