Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice DOI Open Access
Kai Xu,

Irene Covila-Corona,

María Dolores Frutos

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1’s potential specialization hepatic glucose lipid dysregulation, linking it progression MASLD MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1 LKO ) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Язык: Английский

Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice DOI Creative Commons
Kai Xu,

Irene Corona‐Avila,

María Dolores Frutos

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер 1871(4), С. 167746 - 167746

Опубликована: Фев. 27, 2025

The global prevalence of Metabolic Dysfunction-Associated Steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1's potential specialization hepatic glucose lipid dysregulation, linking it progression MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1LKO) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Язык: Английский

Процитировано

1
Fu brick tea supplementation ameliorates non-alcoholic fatty liver disease and associated endotoxemia via maintaining intestinal homeostasis and remodeling hepatic immune microenvironment DOI

Gaolong Zuo,

Meng-Hua Li,

Xiaoli Guo

и другие.

Food Research International, Год журнала: 2025, Номер unknown, С. 116207 - 116207

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Morchella esculenta polysaccharides ameliorate obesity by enriching Bifidobacterium and Bacteroides DOI

Xiaojie Zang,

Xing Jin, Bingshu Liu

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106552 - 106552

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Fecal microbiota transplantation improves growth performance of chickens by increasing the intestinal Lactobacillus and glutamine DOI Creative Commons
Yibin Xu, Kuan Chen, Yulin Huang

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105243 - 105243

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota DOI Creative Commons
Yan Yan, Hai‐Sheng Yuan, Fan Yang

и другие.

AMB Express, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 9, 2024

Язык: Английский

Процитировано

3
The Modulation of Gut Microbiota by Bariatric Metabolic Surgery and Its Role in NAFLD Treatment DOI

小磊 郝

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(08), С. 817 - 825

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice DOI Open Access
Kai Xu,

Irene Covila-Corona,

María Dolores Frutos

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1’s potential specialization hepatic glucose lipid dysregulation, linking it progression MASLD MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1 LKO ) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Язык: Английский

Процитировано

0