Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice DOI Open Access
Kai Xu,

Irene Covila-Corona,

María Dolores Frutos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1’s potential specialization hepatic glucose lipid dysregulation, linking it progression MASLD MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1 LKO ) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Language: Английский

Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice DOI Creative Commons
Kai Xu,

Irene Corona‐Avila,

María Dolores Frutos

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(4), P. 167746 - 167746

Published: Feb. 27, 2025

The global prevalence of Metabolic Dysfunction-Associated Steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1's potential specialization hepatic glucose lipid dysregulation, linking it progression MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1LKO) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Language: Английский

Citations

1
Fecal microbiota transplantation improves growth performance of chickens by increasing the intestinal Lactobacillus and glutamine DOI Creative Commons
Yibin Xu, Kuan Chen, Yulin Huang

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105243 - 105243

Published: May 1, 2025

Language: Английский

Citations

0
Fu brick tea supplementation ameliorates non-alcoholic fatty liver disease and associated endotoxemia via maintaining intestinal homeostasis and remodeling hepatic immune microenvironment DOI

Gaolong Zuo,

Meng-Hua Li,

Xiaoli Guo

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116207 - 116207

Published: March 1, 2025

Language: Английский

Citations

0
Morchella esculenta polysaccharides ameliorate obesity by enriching Bifidobacterium and Bacteroides DOI

Xiaojie Zang,

Xing Jin, Bingshu Liu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106552 - 106552

Published: April 1, 2025

Language: Английский

Citations

0
Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota DOI Creative Commons
Yan Yan, Hai‐Sheng Yuan, Fan Yang

et al.

AMB Express, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

Citations

3
The Modulation of Gut Microbiota by Bariatric Metabolic Surgery and Its Role in NAFLD Treatment DOI

小磊 郝

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 817 - 825

Published: Jan. 1, 2024

Language: Английский

Citations

0
Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice DOI Open Access
Kai Xu,

Irene Covila-Corona,

María Dolores Frutos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) recently recognized for its role in liver diseases, expression is minimal under normal conditions but significantly increases response to stressors like injury. This selective upregulation suggests HKDC1’s potential specialization hepatic glucose lipid dysregulation, linking it progression MASLD MASH. study aims clarify HKDC1 Western diet-induced female mice by examining impact on metabolism, offering insights into as therapeutic target addressing need sex-specific research disease. reveals that elevated obese women correlates pathology. In mouse model, liver-specific knockout (HKDC1 LKO ) protected against obesity, intolerance, features, including steatosis, inflammation, fibrosis. Transcriptomic analysis showed deletion reduced pro-inflammatory pro-fibrotic gene expression, while gut microbiome indicated shift toward MASH-protective bacteria. These findings suggest may exacerbate through inflammatory pathways, making target.

Language: Английский

Citations

0