Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model
Food & Function,
Год журнала:
2024,
Номер
15(13), С. 7136 - 7147
Опубликована: Янв. 1, 2024
Zinc
(Zn)
is
an
important
trace
element;
it
involved
in
the
regulation
and
maintenance
of
many
physiological
functions
organisms
has
anti-inflammatory
antioxidant
properties.
Язык: Английский
Bifidobacterium longum Ameliorates Intestinal Inflammation and Metabolic Biomarkers in Mice Fed a High-Fat Diet with Gliadin by Indoleacrylic Acid
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Язык: Английский
Effects of dietary gluten on body weight and gut microbiota in BALB-C mice using 16 S rRNA-Based analysis
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 7, 2025
Despite
the
widespread
adoption
of
gluten-free
diets
for
weight
management,
relationship
between
gluten
intake
and
obesity
remains
unclear
because
limited
number
controlled
studies
available
in
literature.
Furthermore,
there
is
ongoing
debate
regarding
impact
gluten-containing
on
gut
microbiota.
This
study
aimed
to
investigate
effects
consumption
body
intestinal
microbiota
mice
fed
a
high-fat
diet.
Twenty-four
Bagg
albino
laboratory-bred
(BALB/c)
were
randomly
divided
into
four
groups
oral
gavage
feeding:
standard
diet
control
(SDC),
+
5
mg/day
(SD
gluten),
(HFDC),
(HFD
gluten).
Each
subject's
was
measured
recorded
weekly.
For
analysis,
fecal
samples
collected
weekly
from
cages
after
overnight
cage
changes.
The
analyzed
using
via
16
S
ribosomal
ribonucleic
acid
(rRNA)
method.
Compared
with
diet,
both
high
fat
significantly
increased
gain
(p
<
0.05).
No
significant
difference
observed
total
mesophilic
aerobic
bacterial
count
among
>
However,
addition
positively
affected
Lactobacillus
bulgaricus
Conversely,
negatively
impacted
coliform
bacteria
Escherichia
coli
counts
These
findings
suggest
that
gluten,
when
combined
either
normal
or
contributes
while
exerting
positive
Язык: Английский
The regulatory effects and mechanisms of plant food-derived bioactive components on gut barrier function and intestinal homeostasis: a comprehensive review
Peichun Xie,
Zeliang Ma,
Xiaoshuang Yang
и другие.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 24
Опубликована: Март 27, 2025
The
gut
barrier,
composed
of
physical,
secretory,
immunological,
and
biological
components,
serves
as
the
first
line
defense
against
external
threats.
commensal
microbiota
not
only
functions
a
barrier
to
maintain
intestinal
homeostasis
but
also
produces
metabolites
that
regulate
integrity.
Increasing
evidence
suggests
dysfunction
is
linked
gastrointestinal
diseases,
autoimmune
disorders,
neurological
conditions.
Plant
food-derived
bioactive
components
exhibit
diverse
bioactivities,
including
ability
modulate
improve
function,
potentially
preventing
chronic
diseases.
This
review
explores
mechanisms
underlying
disruption
caused
by
drugs,
diet,
pathogenic
infections,
alcohol.
Additionally,
it
provides
comprehensive
summary
beneficial
effects
specific
plant
on
function
homeostasis,
along
with
their
mechanisms.
By
elucidating
these
interactions,
this
offers
valuable
insights
for
developing
safer,
more
effective,
affordable
plant-based
strategies
prevent
or
mitigate
dysfunction.
Understanding
role
compounds
in
health
may
contribute
novel
dietary
interventions
aimed
at
strengthening
defenses
reducing
risk
diseases
associated
impairment.
Язык: Английский
Inflammation in MASLD Progression and Cancer
JHEP Reports,
Год журнала:
2025,
Номер
unknown, С. 101414 - 101414
Опубликована: Апрель 1, 2025
Язык: Английский
Critical Care Nutrition from a Metabolic Point of View: A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1352 - 1352
Опубликована: Апрель 15, 2025
Background:
Critical
illness
induces
profound
metabolic
alterations,
characterized
by
a
hypermetabolic
state,
insulin
resistance,
protein
catabolism,
and
gut
barrier
dysfunction,
which
contribute
to
increased
morbidity
mortality.
Emerging
evidence
highlights
the
role
of
microbiome
its
metabolites
in
modulating
systemic
inflammation
immune
responses
during
critical
illness.
This
narrative
review
explores
evolution
critically
ill
patients,
impact
dysbiosis
on
disease
progression,
potential
nutrition
metabolism
improving
patient
outcomes.
Methods:
A
comprehensive
literature
search
was
conducted
across
PubMed
Google
Scholar
for
articles
published
up
February
2025.
Search
terms
included
“critical
illness”,
“metabolism”,
“gut
microbiota”,
“nutrition”,
related
keywords.
Articles
English
addressing
changes,
nutritional
strategies
patients
were
included.
After
screening
eligibility,
relevant
synthesized
outline
current
knowledge
identify
gaps.
Results:
Metabolic
changes
progress
through
distinct
phases,
from
catabolism-driven
hypermetabolism
gradual
recovery.
Gut
dysbiosis,
loss
microbial
diversity
permeability,
contributes
organ
dysfunction.
Nutritional
strategies,
including
enteral
nutrition,
probiotics,
prebiotics,
metabolomics-driven
interventions,
may
help
restore
balance,
preserve
integrity,
modulate
responses.
Future
therapy
should
focus
modulation
rather
than
solely
nutrient
deficits.
Conclusions:
Advances
research
metabolomics
offer
new
avenues
personalized
tailored
demands
patients.
Integrating
these
approaches
improve
clinical
functional
recovery
while
mitigating
long-term
consequences
Язык: Английский
Prebiotics mitigate the detrimental effects of High-Fat diet on Memory, anxiety and microglia functionality in ageing mice
Brain Behavior and Immunity,
Год журнала:
2024,
Номер
122, С. 167 - 184
Опубликована: Авг. 12, 2024
Ageing
is
characterised
by
a
progressive
increase
in
systemic
inflammation
and
especially
neuroinflammation.
Neuroinflammation
associated
with
altered
brain
states
that
affect
behaviour,
such
as
an
increased
level
of
anxiety
concomitant
decline
cognitive
abilities.
Although
multiple
factors
play
role
the
development
neuroinflammation,
microglia
have
emerged
crucial
target.
Microglia
are
only
macrophage
population
CNS
parenchyma
plays
maintaining
homeostasis
immune
response,
which
depends
on
activation
subsequent
deactivation
microglia.
Therefore,
microglial
dysfunction
has
major
impact
The
gut
microbiota
been
shown
to
significantly
influence
from
birth
adulthood
terms
development,
proliferation,
function.
Diet
key
modulating
factor
influences
composition
microbiota,
along
prebiotics
support
growth
beneficial
bacteria.
diet
neuroinflammation
behaviour
well
established,
its
relationship
functionality
less
explored.
This
article
establishes
link
between
diet,
animal
results
this
research
stem
experiments
mouse
i.e.,
memory,
anxiety,
studies
functionality,
cytochemistry
(phagocytosis,
cellular
senescence,
ROS
assays),
gene
expression
protein
quantification.
In
addition,
shotgun
sequencing
was
performed
identify
specific
bacterial
families
may
showed
negative
effects
long-term
consumption
high
fat
ageing
mice,
epitomised
body
weight,
glucose
intolerance,
impairment
compared
mice
control
diet.
These
were
consequence
changes
modulated
However,
adding
fructo-
galacto-oligosaccharides,
we
able
mitigate
deleterious
high-fat
Язык: Английский
High-fat intake induces gut microbiota disorders, inflammatory responses and oxidative stress in Nyctereutes procyonoides
Animal Diseases,
Год журнала:
2024,
Номер
4(1)
Опубликована: Авг. 6, 2024
Abstract
The
Nyctereutes
procyonoides
is
highly
regarded
in
the
farming
and
leather
industries
because
of
high
value
its
fur,
which
renders
artificial
feeding
a
crucial
aspect.
However,
high-fat
diets
have
always
been
associated
with
variety
digestive
disorders.
This
study
aimed
to
investigate
impact
on
gut
microbiota
mechanisms
damage
.
16S
rRNA
sequencing
demonstrated
that
caused
diarrhea
intestinal
through
alterations
microbiota:
decrease
abundance
Firmicutes,
an
increase
Proteobacteria
Actinobacteria
,
Enterococcaceae
Escherichia
coli-Shigella
Clostridium
Lactobacillus
Subsequently,
changes
metabolic
pathways,
such
as
amino
fatty
acid
were
identified
by
KEGG
COG
enrichment
analysis,
TLR4/NF-κB/NLRP3
inflammatory
signaling
pathway
was
shown
be
activated
diets.
In
addition,
lead
accumulation
ROS
MDA
reduce
activity
antioxidant
enzymes
GSH-PX
SOD.
Correspondingly,
levels
proinflammatory
cytokines
(IL-6,
IL-1β
TNF-α)
significantly
increased,
apoptosis
necrosis
pathways
colonic
cells
detected,
causing
dramatic
expression
tight
junction
proteins
(Occludin,
E-cadherin,
ZO-1
ZO-2).
conclusion,
altered
structure
community
led
colon
damage.
provides
new
insights
into
health
Graphical
Язык: Английский