High-fat intake induces gut microbiota disorders, inflammatory responses and oxidative stress in Nyctereutes procyonoides DOI Creative Commons
Zhaoming Li,

Chengwei Wei,

Jie Yang

et al.

Animal Diseases, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 6, 2024

Abstract The Nyctereutes procyonoides is highly regarded in the farming and leather industries because of high value its fur, which renders artificial feeding a crucial aspect. However, high-fat diets have always been associated with variety digestive disorders. This study aimed to investigate impact on gut microbiota mechanisms damage . 16S rRNA sequencing demonstrated that caused diarrhea intestinal through alterations microbiota: decrease abundance Firmicutes, an increase Proteobacteria Actinobacteria , Enterococcaceae Escherichia coli-Shigella Clostridium Lactobacillus Subsequently, changes metabolic pathways, such as amino fatty acid were identified by KEGG COG enrichment analysis, TLR4/NF-κB/NLRP3 inflammatory signaling pathway was shown be activated diets. In addition, lead accumulation ROS MDA reduce activity antioxidant enzymes GSH-PX SOD. Correspondingly, levels proinflammatory cytokines (IL-6, IL-1β TNF-α) significantly increased, apoptosis necrosis pathways colonic cells detected, causing dramatic expression tight junction proteins (Occludin, E-cadherin, ZO-1 ZO-2). conclusion, altered structure community led colon damage. provides new insights into health Graphical

Language: Английский

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model DOI
Xiaoran Sun, Shuang Xu, Tianjing Liu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 7136 - 7147

Published: Jan. 1, 2024

Zinc (Zn) is an important trace element; it involved in the regulation and maintenance of many physiological functions organisms has anti-inflammatory antioxidant properties.

Language: Английский

Citations

6
Bifidobacterium longum Ameliorates Intestinal Inflammation and Metabolic Biomarkers in Mice Fed a High-Fat Diet with Gliadin by Indoleacrylic Acid DOI
Ning Wang, Zhangming Pei,

Hongchao Wang

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

0
Effects of dietary gluten on body weight and gut microbiota in BALB-C mice using 16 S rRNA-Based analysis DOI Creative Commons

Merve Sayın Dülger,

Nihal Zekiye Erdem, Emek Dümen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 7, 2025

Despite the widespread adoption of gluten-free diets for weight management, relationship between gluten intake and obesity remains unclear because limited number controlled studies available in literature. Furthermore, there is ongoing debate regarding impact gluten-containing on gut microbiota. This study aimed to investigate effects consumption body intestinal microbiota mice fed a high-fat diet. Twenty-four Bagg albino laboratory-bred (BALB/c) were randomly divided into four groups oral gavage feeding: standard diet control (SDC), + 5 mg/day (SD gluten), (HFDC), (HFD gluten). Each subject's was measured recorded weekly. For analysis, fecal samples collected weekly from cages after overnight cage changes. The analyzed using via 16 S ribosomal ribonucleic acid (rRNA) method. Compared with diet, both high fat significantly increased gain (p < 0.05). No significant difference observed total mesophilic aerobic bacterial count among > However, addition positively affected Lactobacillus bulgaricus Conversely, negatively impacted coliform bacteria Escherichia coli counts These findings suggest that gluten, when combined either normal or contributes while exerting positive

Language: Английский

Citations

0
The regulatory effects and mechanisms of plant food-derived bioactive components on gut barrier function and intestinal homeostasis: a comprehensive review DOI

Peichun Xie,

Zeliang Ma,

Xiaoshuang Yang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

The gut barrier, composed of physical, secretory, immunological, and biological components, serves as the first line defense against external threats. commensal microbiota not only functions a barrier to maintain intestinal homeostasis but also produces metabolites that regulate integrity. Increasing evidence suggests dysfunction is linked gastrointestinal diseases, autoimmune disorders, neurological conditions. Plant food-derived bioactive components exhibit diverse bioactivities, including ability modulate improve function, potentially preventing chronic diseases. This review explores mechanisms underlying disruption caused by drugs, diet, pathogenic infections, alcohol. Additionally, it provides comprehensive summary beneficial effects specific plant on function homeostasis, along with their mechanisms. By elucidating these interactions, this offers valuable insights for developing safer, more effective, affordable plant-based strategies prevent or mitigate dysfunction. Understanding role compounds in health may contribute novel dietary interventions aimed at strengthening defenses reducing risk diseases associated impairment.

Language: Английский

Citations

0
Inflammation in MASLD Progression and Cancer DOI Creative Commons
Yeon Soo Kim,

Y. C. Park,

Hyunsoo Rho

et al.

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101414 - 101414

Published: April 1, 2025

Language: Английский

Citations

0
Critical Care Nutrition from a Metabolic Point of View: A Narrative Review DOI Open Access
Takehiko Oami, Akiyuki Yamamoto,

Shigenobu Ishida

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1352 - 1352

Published: April 15, 2025

Background: Critical illness induces profound metabolic alterations, characterized by a hypermetabolic state, insulin resistance, protein catabolism, and gut barrier dysfunction, which contribute to increased morbidity mortality. Emerging evidence highlights the role of microbiome its metabolites in modulating systemic inflammation immune responses during critical illness. This narrative review explores evolution critically ill patients, impact dysbiosis on disease progression, potential nutrition metabolism improving patient outcomes. Methods: A comprehensive literature search was conducted across PubMed Google Scholar for articles published up February 2025. Search terms included “critical illness”, “metabolism”, “gut microbiota”, “nutrition”, related keywords. Articles English addressing changes, nutritional strategies patients were included. After screening eligibility, relevant synthesized outline current knowledge identify gaps. Results: Metabolic changes progress through distinct phases, from catabolism-driven hypermetabolism gradual recovery. Gut dysbiosis, loss microbial diversity permeability, contributes organ dysfunction. Nutritional strategies, including enteral nutrition, probiotics, prebiotics, metabolomics-driven interventions, may help restore balance, preserve integrity, modulate responses. Future therapy should focus modulation rather than solely nutrient deficits. Conclusions: Advances research metabolomics offer new avenues personalized tailored demands patients. Integrating these approaches improve clinical functional recovery while mitigating long-term consequences

Language: Английский

Citations

0
Prebiotics mitigate the detrimental effects of High-Fat diet on Memory, anxiety and microglia functionality in ageing mice DOI Creative Commons
Akshay Kumar Vijaya,

Simonas Kuras,

Egidijus Šimoliūnas

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 167 - 184

Published: Aug. 12, 2024

Ageing is characterised by a progressive increase in systemic inflammation and especially neuroinflammation. Neuroinflammation associated with altered brain states that affect behaviour, such as an increased level of anxiety concomitant decline cognitive abilities. Although multiple factors play role the development neuroinflammation, microglia have emerged crucial target. Microglia are only macrophage population CNS parenchyma plays maintaining homeostasis immune response, which depends on activation subsequent deactivation microglia. Therefore, microglial dysfunction has major impact The gut microbiota been shown to significantly influence from birth adulthood terms development, proliferation, function. Diet key modulating factor influences composition microbiota, along prebiotics support growth beneficial bacteria. diet neuroinflammation behaviour well established, its relationship functionality less explored. This article establishes link between diet, animal results this research stem experiments mouse i.e., memory, anxiety, studies functionality, cytochemistry (phagocytosis, cellular senescence, ROS assays), gene expression protein quantification. In addition, shotgun sequencing was performed identify specific bacterial families may showed negative effects long-term consumption high fat ageing mice, epitomised body weight, glucose intolerance, impairment compared mice control diet. These were consequence changes modulated However, adding fructo- galacto-oligosaccharides, we able mitigate deleterious high-fat

Language: Английский

Citations

2
High-fat intake induces gut microbiota disorders, inflammatory responses and oxidative stress in Nyctereutes procyonoides DOI Creative Commons
Zhaoming Li,

Chengwei Wei,

Jie Yang

et al.

Animal Diseases, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 6, 2024

Abstract The Nyctereutes procyonoides is highly regarded in the farming and leather industries because of high value its fur, which renders artificial feeding a crucial aspect. However, high-fat diets have always been associated with variety digestive disorders. This study aimed to investigate impact on gut microbiota mechanisms damage . 16S rRNA sequencing demonstrated that caused diarrhea intestinal through alterations microbiota: decrease abundance Firmicutes, an increase Proteobacteria Actinobacteria , Enterococcaceae Escherichia coli-Shigella Clostridium Lactobacillus Subsequently, changes metabolic pathways, such as amino fatty acid were identified by KEGG COG enrichment analysis, TLR4/NF-κB/NLRP3 inflammatory signaling pathway was shown be activated diets. In addition, lead accumulation ROS MDA reduce activity antioxidant enzymes GSH-PX SOD. Correspondingly, levels proinflammatory cytokines (IL-6, IL-1β TNF-α) significantly increased, apoptosis necrosis pathways colonic cells detected, causing dramatic expression tight junction proteins (Occludin, E-cadherin, ZO-1 ZO-2). conclusion, altered structure community led colon damage. provides new insights into health Graphical

Language: Английский

Citations

1