Journal of health economics and outcomes research,
Год журнала:
2024,
Номер
11(2)
Опубликована: Ноя. 5, 2024
Background:
Infections
attributable
to
respiratory
syncytial
virus
(RSV)
are
a
major
cause
of
hospitalization
among
young
children
worldwide.
Despite
substantial
clinical
and
economic
burden,
real-world
data
associated
with
RSV
infections
in
the
United
Arab
Emirates
(UAE)
limited.
Objectives:
This
study
aimed
assess
(<18
years)
diagnosed
epidemiology,
seasonality,
comorbidities,
treatment
patterns,
length
hospital
stay,
healthcare
resource
utilization
(HCRU),
costs
pediatric
infection
Dubai,
UAE.
Methods:
10-year
retrospective
cohort
(Jan.
1,
2014–Sept.
30,
2023)
utilized
Dubai
Real-World
Database,
private
insurance
claims
database.
Patients
aged
<18
years
first-episode
diagnosis
claim
(primary
or
secondary,
admission)
for
any
time
during
index
period
2014–June
were
included.
Outcomes
analyzed
3-month
follow-up.
stratified
into
3
cohorts:
Cohort
1
(<2
years),
2
(2
<6
(6
years).
Results:
Of
28
011
patients
identified,
25
729
infection.
An
increasing
trend
reported
cases
was
observed
from
2014
2022,
an
average
annual
increase
55%.
Half
(49.3%)
belonged
mean
age
0.6
years,
while
less
than
2%
had
known
risk
factors
22%
hospitalized.
In
32.0%
upper
tract
infections,
39.4%
lower
44.4%
“other
disease.”
The
about
4
days
across
all
cohorts.
total
cost
highest
<2
amounting
US
$9
798
174
(median,
$2241.30).
Conclusion:
Among
patients,
49.3%
few
recognized
factors.
hospitalized,
stay
days;
totaled
174.
These
findings
can
inform
stakeholders
future
policy
measures
need
effective
preventive
strategies.
The Pediatric Infectious Disease Journal,
Год журнала:
2024,
Номер
43(5), С. 410 - 414
Опубликована: Янв. 22, 2024
The
aim
of
the
study
was
to
determine
burden
respiratory
syncytial
virus
(RSV)
and
influenza
disease
during
COVID-19
pandemic
at
2
Austrian
urban
pediatric
centers
between
October
1,
2019
April
30,
2022.
Journal of Medical Virology,
Год журнала:
2025,
Номер
97(4)
Опубликована: Апрель 1, 2025
ABSTRACT
The
resurgence
of
respiratory
syncytial
virus
(RSV)
has
become
a
major
concern
recently.
This
study
aimed
to
describe
the
temporal
dynamics,
genotype
variability
and
disease
severity
RSV
infection
after
end
Zero‐COVID‐19
policy
in
Beijing,
China.
A
total
905
patients
were
positive
for
at
National
Center
Respiratory
Medicine
Beijing
from
November
2019
April
2024.
Of
these,
238
samples
different
successfully
sequenced,
96
which
identified
as
RSV‐A
142
RSV‐B.
Phylogenetic
analyses
performed
investigate
genetic
diversity.
first
surge
was
quite
intense
occurred
out
season,
mainly
affecting
children.
subsequent
outbreak
had
significant
impact
among
adults.
cases
caused
by
various
clades
new
clade
B.D.E.1
main
cause
epidemic
Pneumonia
immunocompromised
hosts
more
common
compared
other
clades.
Accumulation
substitutions
could
confer
fitness
advantage
vivo.
However,
there
no
statistical
difference
clinical
outcomes
between
infected
those
addressed
timing
trends
infections,
focusing
on
outbreaks,
molecular
characterization,
associated
with
novel
B.D.E.1.
effective
prevention
strategy
infections
childhood,
immunosuppressed
adults
elderly
might
be
warranted.
Pediatric Allergy and Immunology,
Год журнала:
2024,
Номер
35(6)
Опубликована: Июнь 1, 2024
Abstract
Background
Respiratory
Syncytial
Virus
(RSV)
is
the
leading
cause
of
hospitalization
in
infants.
RSV
bronchiolitis
associated
with
an
increased
risk
subsequent
wheezing.
We
aimed
to
document
parents'
perception
link
between
infection
and
wheezing,
wheezing‐related
healthcare
family
resources
use,
its
impact
on
daily
life.
Methods
This
cross‐sectional
online
survey
enrolled
1200
parents
at
least
one
child
≤6y
living
United
States,
Kingdom,
Spain,
Italy.
Children
diagnosed
before
age
2
years
were
included
group,
those
never
Reference
group.
Results
The
odds
wheezing
4.5‐fold
(95%CI
3.5–5.9)
higher
than
7.7‐fold
5.4–11.1)
among
children
who
hospitalized,
9‐fold
5.1–16.6)
admitted
pediatric
intensive
care
bronchiolitis.
Similar
trends
observed
across
all
countries.
In
total,
57%
reported
their
child's
have
moderate
severe
emotional
well‐being,
53%
life
activities
and/or
social
64%
moderate–severe
quality
sleep
49%
46%
a
children's
well‐being
physical
activities.
Conclusions
suggests
association
different
Wheezing,
especially
infection,
was
utilization
costs,
significantly
impacted
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 24, 2024
Off-season
upsurge
of
respiratory
syncytial
virus
(RSV)
infection
with
changed
characteristics
and
heightened
clinical
severity
during
the
post-COVID-19
era
are
raising
serious
concerns.
This
study
aimed
to
develop
validate
a
nomogram
for
predicting
risk
severe
acute
lower
tract
(SALRTI)
in
children
hospitalized
RSV
using
machine
learning
techniques.
A
multicenter
retrospective
was
performed
nine
tertiary
hospitals
Yunnan,
China,
enrolling
at
seven
participating
January-December
2023
into
development
dataset.
Thirty-nine
variables
covering
demographic,
clinical,
laboratory
were
collected.
Primary
screening
dimension
reduction
data
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
regression,
followed
by
identification
independent
factors
RSV-associated
SALRTI
Logistic
thus
finally
establishing
predictive
model.
Performance
internally
evaluated
receiver
operating
characteristic
(ROC)
curve,
calibration
decision
curve
analysis
(DCA)
based
on
External
validation
our
model
conducted
same
methods
two
cohorts
comprising
pediatric
inpatients
from
another
between
January-March
2024.
The
dataset
included
1102
patients,
239
(21.7%)
whom
developed
SALRTI;
while
external
249
patients
(142
Lincang
subset
107
Dali
subset),
58
(23.3%)
diagnosed
as
SALRTI.
Nine
variables,
including
age,
preterm
birth,
underlying
condition,
seizures,
neutrophil-lymphocyte
ratio
(NLR),
interleukin-6
(IL-6),
lactate
dehydrogenase
(LDH),
D-dimer,
co-infection,
eventually
confirmed
established
via
integrating
these
predictors.
In
both
internal
validations,
ROC
curves
indicated
that
had
satisfactory
discrimination
ability,
demonstrated
good
agreement
nomogram-predicted
observed
probabilities
outcome,
DCA
showed
possessed
favorable
application
potential.
novel
combining
several
common
inflammatory
indicators
successfully
predict
Good
performance
effectiveness
this
validations.
Journal of health economics and outcomes research,
Год журнала:
2024,
Номер
unknown, С. 133 - 144
Опубликована: Ноя. 5, 2024
Background:
Infections
attributable
to
respiratory
syncytial
virus
(RSV)
are
a
major
cause
of
hospitalization
among
young
children
worldwide.
Despite
substantial
clinical
and
economic
burden,
real-world
data
associated
with
RSV
infections
in
the
United
Arab
Emirates
(UAE)
limited.
Objectives:
This
study
aimed
assess
(<18
years)
diagnosed
epidemiology,
seasonality,
comorbidities,
treatment
patterns,
length
hospital
stay,
healthcare
resource
utilization
(HCRU),
costs
pediatric
infection
Dubai,
UAE.
Methods:
10-year
retrospective
cohort
(Jan.
1,
2014–Sept.
30,
2023)
utilized
Dubai
Real-World
Database,
private
insurance
claims
database.
Patients
aged
<18
years
first-episode
diagnosis
claim
(primary
or
secondary,
admission)
for
any
time
during
index
period
2014–June
were
included.
Outcomes
analyzed
3-month
follow-up.
stratified
into
3
cohorts:
Cohort
1
(<2
years),
2
(2
<6
(6
years).
Results:
Of
28
011
patients
identified,
25
729
infection.
An
increasing
trend
reported
cases
was
observed
from
2014
2022,
an
average
annual
increase
55%.
Half
(49.3%)
belonged
mean
age
0.6
years,
while
less
than
2%
had
known
risk
factors
22%
hospitalized.
In
32.0%
upper
tract
infections,
39.4%
lower
44.4%
“other
disease.”
The
about
4
days
across
all
cohorts.
total
cost
highest
<2
amounting
US
$9
798
174
(median,
$2241.30).
Conclusion:
Among
patients,
49.3%
few
recognized
factors.
hospitalized,
stay
days;
totaled
174.
These
findings
can
inform
stakeholders
future
policy
measures
need
effective
preventive
strategies.
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 26, 2024
Human
Respiratory
Syncytial
Virus
(HRSV)
is
a
primary
cause
of
severe
pediatric
respiratory
infections,
particularly
in
infants
and
young
children,
often
resulting
hospitalization.
The
virus
possesses
high
degree
mutagenic
potential,
contributing
to
significant
antigenic
diversity,
which
complicates
immune
responses
poses
challenges
for
vaccine
development
disease
management.
This
study
was
conducted
Jordan
from
2022
2023
epidemiologically
determine
the
prevalence
molecular
characteristics
RSV.
A
total
288
nasopharyngeal
(NP)
swabs
were
collected
hospitalized
children
at
Prince
Hamza
Hospital,
Amman,
Jordan.
All
samples
screened
common
viral
bacterial
pathogens
using
PCR.
partial
segment
G
gene
RSV
amplified
characterization
phylogenetic
tree
analysis.
Viral
and/or
infection
identified
71.9%
(207/288)
tested
specimens.
Among
these,
35
(12.2%,
35/288)
positive
Specific
subgroup
PCR
analysis
(25,
71.4%)
RSV-A,
(4,
11.4%)
RSV-B,
(6,
17.1%)
could
not
be
our
set
primers.
Phylogenetic
revealed
that
RSV-A
ON1
RSV-B
BA9
genotype
strains
predominate
We
observed
multiple
substitutions
studied
sample
would
drive
variation
level
antigenicity
pathogenicity
Glycosylation
sites
consistent
with
previously
reported
studies.
provides
updated
epidemiological
data
on
circulating
their
characteristics.
Continuous
surveillance
informs
development,
guides
public
health
interventions,
enables
timely
administration
prophylactic
treatments,
reducing
burden
RSV-related
illness.
The Open Respiratory Medicine Journal,
Год журнала:
2024,
Номер
18(1)
Опубликована: Дек. 17, 2024
Traditional
testing
methods
in
the
Middle
East
Region,
including
United
Arab
Emirates
(UAE),
particularly
of
Respiratory
Syncytial
Virus
(RSV),
influenza,
group
A
streptococcus
(GAS),
and
COVID-19
have
potential
to
be
upgraded
new
advanced
diagnostics
that
improve
lead
time
diagnosis,
consumption
healthcare
resources
patient
experience.
In
addition,
based
on
research,
it
was
reported
there
is
an
underreporting
respiratory
cases,
overuse
antibiotics,
prolonged
hospitalizations
which
posing
pressure
UAE
stakeholders.
literature
review
done
exploring
UAE's
current
diagnostic
practices,
recommended
guidelines,
gaps,
challenges
RSV,
GAS,
Influenza,
COVID-19.
This
followed
by
stakeholder
discussions
focusing
assessing
usage
rapid
molecular
point-of-care
(POC)
tests,
gaps
targeted
profiles
for
POC
testing,
impact
management
infections.
round
table
discussion
with
experts,
insurance
key
opinion
leaders,
pulmonologists
discussed
opportunities
treating
diseases.
stakeholders
suggest
introducing
alternative
up-to-date
such
as
expected
outcomes,
optimize
resources,
develop
a
robust
case
tract
It
essential
emphasize
precision
medicine
reinforced,
efficiency
achieved,
overall
population
health
enhanced.
Frontiers in Pediatrics,
Год журнала:
2023,
Номер
11
Опубликована: Дек. 15, 2023
Background
The
lung
ultrasound
(LUS)
score
can
be
a
useful
tool
to
predict
the
need
for
respiratory
support
and
length
of
hospital
stay
in
infants
with
bronchiolitis.
Objective
To
compare
features
neonates
up
three
months
age
bronchiolitis
determine
whether
LUS
scores
(range
0–36)
differ
coinfections
or
not.
Methods
Neonates
younger
than
admitted
neonatal
units
from
October
2022
March
2023,
who
underwent
evaluation
on
admission,
were
included
this
retrospective
study.
Results
We
60
patients
at
admission.
Forty-two
(70.0%)
had
single
viral
infection.
Eighteen
(30.0%)
coinfection:
fifteen
(25.0%)
more
one
virus
PCR;
infant
(1.7%)
both
coinfection
viral-bacteria
coinfection;
two
(3.3%)
coinfection.
Infants
infection
those
similar
globally
different
zones.
An
higher
8
was
identified
significantly
any
(
p
=
0.0035),
whereas
an
13
mechanical
ventilation
0.024).
Conclusion
In
our
small
cohort
hospitalized
bronchiolitis,
we
found
no
statistically
significant
differences
admission
between
multiple
infections.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 30, 2024
Abstract
Background
Respiratory
syncytial
virus
(RSV)
is
one
of
the
primary
pathogens
responsible
for
acute
lower
respiratory
tract
infections
in
children.
Most
studies
assessing
detection
rate
children
have
utilized
method
sentinel
hospital
surveillance.
While
this
can
partially
reflect
disease
burden
on
population,
it
does
not
fully
account
catchment
area
hospitals
study
population.
Hence,
relevant
weight
was
adjusted
through
etiological
monitoring
and
community
consultation
behavior
parameters.
The
incidence
RSV
Pudong
New
Area
Shanghai
be
estimated
more
accurately.
Objectives
aimed
to
protect
rates
virus(RSV)
outpatient,
emergency
departments,
Area,
Shanghai.
Also
included
are
data
due
This
will
serve
as
a
foundation
formulating
healthcare
policies
conducting
health
economic
evaluations.
Methods
Between
2014
2022,
infection
(ARI)
patients
were
monitored
every
1
week
at
hospitals,
we
obtained
basic
characteristics
ARI
detected
viruses.
We
analyzed
various
years
among
different
populations.
In
established
investigation
sites
throughout
district
conducted
Hospitalized
Utilization
Attitude
Survey
(HUAS)
3,225
residents
aged
14
below.
survey
understand
healthcare-seeking
behaviors
after
experiencing
determine
coverage
visit
By
combining
results
from
surveillance,
outpatient
pediatric
RSV.
comparison
using
chi-square
tests,
with
significance
level
P
<
0.05
indicating
statistically
significant
differences.
Results
From
positive
5.36%.
Among
males,
there
126
cases
(5.78%),
which
higher
than
90
(4.86%)
females.
As
distribution
by
age
group,
highest
seen
under-three
group.
There
differences
groups,
statistical
(P
0.001).
hospitalization
(10.54%)
(2.67%),
difference
between
two
significant.
According
HUAS
results,
approximately
33.74%.
36.67%.
number
2022
428,500
6.58
per
100.
around
1,168,500
17.95
100,
variations
across
years.
2015,
both
reached
their
peak
values,
15.39%
41.96%,
respectively.
Additionally,
except
2019
occurring
spring,
other
eight
peaked
autumn
season.
Conclusions
first
combine
surveillance
service
utilization
provide
an
initial
assessment
Area.
found
severe
2015
2017,
followed
declining
trend.
Furthermore,
season
identified
period
