Respiratory Syncytial Virus and Influenza During the COVID-19 Pandemic: A Two-center Experience

The Pediatric Infectious Disease Journal, Journal Year: 2024, Volume and Issue: 43(5), P. 410 - 414

Published: Jan. 22, 2024

The aim of the study was to determine burden respiratory syncytial virus (RSV) and influenza disease during COVID-19 pandemic at 2 Austrian urban pediatric centers between October 1, 2019 April 30, 2022.

Language: Английский

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Epidemic Outbreak of Respiratory Syncytial Virus Infection After the end of the Zero‐COVID‐19 Policy in China: Molecular Characterization and Disease Severity Associated With a Novel RSV‐B Clade

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(4)

Published: April 1, 2025

ABSTRACT The resurgence of respiratory syncytial virus (RSV) has become a major concern recently. This study aimed to describe the temporal dynamics, genotype variability and disease severity RSV infection after end Zero‐COVID‐19 policy in Beijing, China. A total 905 patients were positive for at National Center Respiratory Medicine Beijing from November 2019 April 2024. Of these, 238 samples different successfully sequenced, 96 which identified as RSV‐A 142 RSV‐B. Phylogenetic analyses performed investigate genetic diversity. first surge was quite intense occurred out season, mainly affecting children. subsequent outbreak had significant impact among adults. cases caused by various clades new clade B.D.E.1 main cause epidemic Pneumonia immunocompromised hosts more common compared other clades. Accumulation substitutions could confer fitness advantage vivo. However, there no statistical difference clinical outcomes between infected those addressed timing trends infections, focusing on outbreaks, molecular characterization, associated with novel B.D.E.1. effective prevention strategy infections childhood, immunosuppressed adults elderly might be warranted.

Language: Английский

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Parent's perception of respiratory syncytial virus and subsequent wheezing burden: A multi‐country cross‐sectional survey

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(6)

Published: June 1, 2024

Abstract Background Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in infants. RSV bronchiolitis associated with an increased risk subsequent wheezing. We aimed to document parents' perception link between infection and wheezing, wheezing‐related healthcare family resources use, its impact on daily life. Methods This cross‐sectional online survey enrolled 1200 parents at least one child ≤6y living United States, Kingdom, Spain, Italy. Children diagnosed before age 2 years were included group, those never Reference group. Results The odds wheezing 4.5‐fold (95%CI 3.5–5.9) higher than 7.7‐fold 5.4–11.1) among children who hospitalized, 9‐fold 5.1–16.6) admitted pediatric intensive care bronchiolitis. Similar trends observed across all countries. In total, 57% reported their child's have moderate severe emotional well‐being, 53% life activities and/or social 64% moderate–severe quality sleep 49% 46% a children's well‐being physical activities. Conclusions suggests association different Wheezing, especially infection, was utilization costs, significantly impacted

Language: Английский

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A novel combined nomogram for predicting severe acute lower respiratory tract infection in children hospitalized for RSV infection during the post-COVID-19 period

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Off-season upsurge of respiratory syncytial virus (RSV) infection with changed characteristics and heightened clinical severity during the post-COVID-19 era are raising serious concerns. This study aimed to develop validate a nomogram for predicting risk severe acute lower tract (SALRTI) in children hospitalized RSV using machine learning techniques. A multicenter retrospective was performed nine tertiary hospitals Yunnan, China, enrolling at seven participating January-December 2023 into development dataset. Thirty-nine variables covering demographic, clinical, laboratory were collected. Primary screening dimension reduction data Least Absolute Shrinkage Selection Operator (LASSO) regression, followed by identification independent factors RSV-associated SALRTI Logistic thus finally establishing predictive model. Performance internally evaluated receiver operating characteristic (ROC) curve, calibration decision curve analysis (DCA) based on External validation our model conducted same methods two cohorts comprising pediatric inpatients from another between January-March 2024. The dataset included 1102 patients, 239 (21.7%) whom developed SALRTI; while external 249 patients (142 Lincang subset 107 Dali subset), 58 (23.3%) diagnosed as SALRTI. Nine variables, including age, preterm birth, underlying condition, seizures, neutrophil-lymphocyte ratio (NLR), interleukin-6 (IL-6), lactate dehydrogenase (LDH), D-dimer, co-infection, eventually confirmed established via integrating these predictors. In both internal validations, ROC curves indicated that had satisfactory discrimination ability, demonstrated good agreement nomogram-predicted observed probabilities outcome, DCA showed possessed favorable application potential. novel combining several common inflammatory indicators successfully predict Good performance effectiveness this validations.

Language: Английский

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Retrospective Analysis of RSV Infection in Pediatric Patients: Epidemiology, Comorbidities, Treatment, and Costs in Dubai (2014-2023)

Journal of health economics and outcomes research, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 144

Published: Nov. 5, 2024

Background: Infections attributable to respiratory syncytial virus (RSV) are a major cause of hospitalization among young children worldwide. Despite substantial clinical and economic burden, real-world data associated with RSV infections in the United Arab Emirates (UAE) limited. Objectives: This study aimed assess (<18 years) diagnosed epidemiology, seasonality, comorbidities, treatment patterns, length hospital stay, healthcare resource utilization (HCRU), costs pediatric infection Dubai, UAE. Methods: 10-year retrospective cohort (Jan. 1, 2014–Sept. 30, 2023) utilized Dubai Real-World Database, private insurance claims database. Patients aged <18 years first-episode diagnosis claim (primary or secondary, admission) for any time during index period 2014–June were included. Outcomes analyzed 3-month follow-up. stratified into 3 cohorts: Cohort 1 (<2 years), 2 (2 <6 (6 years). Results: Of 28 011 patients identified, 25 729 infection. An increasing trend reported cases was observed from 2014 2022, an average annual increase 55%. Half (49.3%) belonged mean age 0.6 years, while less than 2% had known risk factors 22% hospitalized. In 32.0% upper tract infections, 39.4% lower 44.4% “other disease.” The about 4 days across all cohorts. total cost highest <2 amounting US $9 798 174 (median, $2241.30). Conclusion: Among patients, 49.3% few recognized factors. hospitalized, stay days; totaled 174. These findings can inform stakeholders future policy measures need effective preventive strategies.

Language: Английский

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Molecular characterization of human respiratory syncytial virus strains circulating among hospitalized children in Jordan

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 26, 2024

Human Respiratory Syncytial Virus (HRSV) is a primary cause of severe pediatric respiratory infections, particularly in infants and young children, often resulting hospitalization. The virus possesses high degree mutagenic potential, contributing to significant antigenic diversity, which complicates immune responses poses challenges for vaccine development disease management. This study was conducted Jordan from 2022 2023 epidemiologically determine the prevalence molecular characteristics RSV. A total 288 nasopharyngeal (NP) swabs were collected hospitalized children at Prince Hamza Hospital, Amman, Jordan. All samples screened common viral bacterial pathogens using PCR. partial segment G gene RSV amplified characterization phylogenetic tree analysis. Viral and/or infection identified 71.9% (207/288) tested specimens. Among these, 35 (12.2%, 35/288) positive Specific subgroup PCR analysis (25, 71.4%) RSV-A, (4, 11.4%) RSV-B, (6, 17.1%) could not be our set primers. Phylogenetic revealed that RSV-A ON1 RSV-B BA9 genotype strains predominate We observed multiple substitutions studied sample would drive variation level antigenicity pathogenicity Glycosylation sites consistent with previously reported studies. provides updated epidemiological data on circulating their characteristics. Continuous surveillance informs development, guides public health interventions, enables timely administration prophylactic treatments, reducing burden RSV-related illness.

Language: Английский

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Recommendations on Rapid Diagnostic Point-of-care Molecular Tests for Respiratory Infections in the United Arab Emirates

The Open Respiratory Medicine Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Dec. 17, 2024

Traditional testing methods in the Middle East Region, including United Arab Emirates (UAE), particularly of Respiratory Syncytial Virus (RSV), influenza, group A streptococcus (GAS), and COVID-19 have potential to be upgraded new advanced diagnostics that improve lead time diagnosis, consumption healthcare resources patient experience. In addition, based on research, it was reported there is an underreporting respiratory cases, overuse antibiotics, prolonged hospitalizations which posing pressure UAE stakeholders. literature review done exploring UAE's current diagnostic practices, recommended guidelines, gaps, challenges RSV, GAS, Influenza, COVID-19. This followed by stakeholder discussions focusing assessing usage rapid molecular point-of-care (POC) tests, gaps targeted profiles for POC testing, impact management infections. round table discussion with experts, insurance key opinion leaders, pulmonologists discussed opportunities treating diseases. stakeholders suggest introducing alternative up-to-date such as expected outcomes, optimize resources, develop a robust case tract It essential emphasize precision medicine reinforced, efficiency achieved, overall population health enhanced.

Language: Английский

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The burden of respiratory syncytial virus infection in children in Shanghai, China,2014 to 2022：a retrospective observational study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Background Respiratory syncytial virus (RSV) is one of the primary pathogens responsible for acute lower respiratory tract infections in children. Most studies assessing detection rate children have utilized method sentinel hospital surveillance. While this can partially reflect disease burden on population, it does not fully account catchment area hospitals study population. Hence, relevant weight was adjusted through etiological monitoring and community consultation behavior parameters. The incidence RSV Pudong New Area Shanghai be estimated more accurately. Objectives aimed to protect rates virus(RSV) outpatient, emergency departments, Area, Shanghai. Also included are data due This will serve as a foundation formulating healthcare policies conducting health economic evaluations. Methods Between 2014 2022, infection (ARI) patients were monitored every 1 week at hospitals, we obtained basic characteristics ARI detected viruses. We analyzed various years among different populations. In established investigation sites throughout district conducted Hospitalized Utilization Attitude Survey (HUAS) 3,225 residents aged 14 below. survey understand healthcare-seeking behaviors after experiencing determine coverage visit By combining results from surveillance, outpatient pediatric RSV. comparison using chi-square tests, with significance level P < 0.05 indicating statistically significant differences. Results From positive 5.36%. Among males, there 126 cases (5.78%), which higher than 90 (4.86%) females. As distribution by age group, highest seen under-three group. There differences groups, statistical (P 0.001). hospitalization (10.54%) (2.67%), difference between two significant. According HUAS results, approximately 33.74%. 36.67%. number 2022 428,500 6.58 per 100. around 1,168,500 17.95 100, variations across years. 2015, both reached their peak values, 15.39% 41.96%, respectively. Additionally, except 2019 occurring spring, other eight peaked autumn season. Conclusions first combine surveillance service utilization provide an initial assessment Area. found severe 2015 2017, followed declining trend. Furthermore, season identified period

Language: Английский

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Prevalence and Seasonal Patterns of 16 Common Viral Respiratory Pathogens during the COVID-19 Pandemic in Gauteng Province, South Africa, 2020–2021

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1325 - 1325

Published: Aug. 19, 2024

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic resulted in widespread morbidity and mortality, but generally, diagnosis of other viruses was limited. This study aimed to assess prevalence during 2020/2021 among patients all ages who accessed care at public healthcare facilities Gauteng Province, South Africa. Laboratory for viruses, with or without SARS-CoV-2, conducted via multiplex real-time polymerase chain reactions using specimens. A total 1776 were included from 1 April 2020 31 March 2021, which 766 (43.1%) positive than SARS-CoV-2. RV (368/1776; 20.7%) most prevalent, followed RSV (304/1776; 17.1%), AdV (112/1776; 6.3%) EV (105/1776; 5.9%). hCoV-OC43 (39/1776; 2.2%) prevalent common coronavirus. SARS-CoV-2 co-infections detected 4.8% (24/500) patients. Only 27.1% (482/1776) admitted high-care intensive units. decrease virus detections observed, except RSV, hCoV-OC43. increased while influenza A/B remained undetected.

Language: Английский

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Transforming Respiratory Tract Infection Diagnosis in the Kingdom of Saudi Arabia through Point-of-Care Testing: A White Paper for Policy Makers

Diagnostic Microbiology and Infectious Disease, Journal Year: 2024, Volume and Issue: 110(4), P. 116530 - 116530

Published: Sept. 13, 2024

Language: Английский

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