Metabolomic analysis of the intrinsic resistance mechanisms of Microtus fortis against Schistosoma japonicum infection DOI Creative Commons

Tianqiong He,

Du Zhang,

Yixin Wen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 21, 2024

Abstract Microtus fortis (M. fortis) is the only mammal known in China that intrinsically resistant to Schistosoma japonicum (S. japonicum) infection. Nevertheless, underlying resistance mechanism of M. against schistosomes are still unclear. In this study, we detected and compared colon aqueous extracts serum metabolic profiles between ICR mice before after S. infection using liquid chromatography-mass spectrometry (LC-MS). We identified 232 specific extract metabolites 79 infected with or without at two weeks those mice, which might be closely correlated time-course schistosomiasis progression could also used as indicators for japonicum, example, nonadecanoic acid, hesperetin, glycocholic 2-Aminobenzoic 6-hydroxydaidzein spermidine. And enriched pathways were further identified, our findings revealed induced changes involved a variety including amino acid metabolism, lipid ABC transporters, central carbon metabolism cancer bile secretion. These results indicated significantly different will provide new insights into identify promising candidates use drugs schistosomes.

Язык: Английский

How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis DOI Creative Commons

Yvonne Lange,

Theodore L. Steck

Progress in Lipid Research, Год журнала: 2024, Номер 96, С. 101304 - 101304

Опубликована: Ноя. 1, 2024

How do cells coordinate the diverse elements that regulate their cholesterol homeostasis? Our model postulates membrane forms simple complexes with bilayer phospholipids. The phospholipids in plasma are of high affinity; consequently, they fully complexed sterol. This sets resting level cholesterol. Cholesterol excess stoichiometric equivalence point these has chemical activity; we refer to it as active It equilibrates low affinity intracellular membranes where serves a negative feedback signal manifold regulatory proteins rein ongoing accretion. We tested review literature regarding fourteen homeostatic enterocytes. provided strong albeit indirect support for following hypothesis. Active inhibits uptake and biosynthesis by suppressing both expression activity gene products activated SREBP-2; namely, HMGCR, LDLR NPC1L1. also reduces free cell serving substrate its esterification ACAT synthesis side-chain oxysterols, 27-hydroxycholesterol particular. oxysterols drive depletion promoting destruction HMGCR stimulating sterol well activation LXR. latter fosters multiple proteins, including four transporters which is likely substrate. By nulling cholesterol, maintains cellular at physiologic set point.

Язык: Английский

Процитировано

1
Influence of APOE4 genotype on PCSK9-lipids association in cerebrospinal fluid and serum of patients in the Alzheimer's disease continuum DOI
Bianca Papotti, Marcella Palumbo, Maria Pia Adorni

и другие.

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 102(1), С. 162 - 172

Опубликована: Окт. 15, 2024

Alterations in factors involved cholesterol homeostasis are critical Alzheimer's disease (AD), but the stage of occurrence, their specific association, and a possible relationship with

Язык: Английский

Процитировано

1
Peripartum Depression and Its Underlying Mechanisms: Transmitters, Information, Endocrinology, and Beyond DOI
Tsachi Ein‐Dor

Springer eBooks, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Metabolomic Analysis of Rat Arterial Serum Under Hypobaric Hypoxia: Adaptive Regulation of Physiological Systems by Metabolic Reprogramming DOI
David W.L.,

Baozhong Xin,

Bin Xie

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Metabolomic analysis of the intrinsic resistance mechanisms of Microtus fortis against Schistosoma japonicum infection DOI Creative Commons

Tianqiong He,

Du Zhang,

Yixin Wen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 21, 2024

Abstract Microtus fortis (M. fortis) is the only mammal known in China that intrinsically resistant to Schistosoma japonicum (S. japonicum) infection. Nevertheless, underlying resistance mechanism of M. against schistosomes are still unclear. In this study, we detected and compared colon aqueous extracts serum metabolic profiles between ICR mice before after S. infection using liquid chromatography-mass spectrometry (LC-MS). We identified 232 specific extract metabolites 79 infected with or without at two weeks those mice, which might be closely correlated time-course schistosomiasis progression could also used as indicators for japonicum, example, nonadecanoic acid, hesperetin, glycocholic 2-Aminobenzoic 6-hydroxydaidzein spermidine. And enriched pathways were further identified, our findings revealed induced changes involved a variety including amino acid metabolism, lipid ABC transporters, central carbon metabolism cancer bile secretion. These results indicated significantly different will provide new insights into identify promising candidates use drugs schistosomes.

Язык: Английский

Процитировано

0